中国组织工程研究

中国组织工程研究 ›› 2025, Vol. 29 ›› Issue (4): 839-845.doi: 10.12307/2025.213

• 生物材料综述 biomaterial review • 上一篇    下一篇

可降解锌基合金在骨缺损修复重建中的应用及研究热点和不足

刘浩洋1，谢  强2，沈梦然1，任岩松3，马金辉4，王佰亮4，岳德波4，王卫国4   

  1. 1北京大学中日友好临床医学院，北京市  100029；2重庆医科大学，重庆市  400016；3北京大学医学部，北京市  100191；4中日友好医院骨科·关节外科，北京市  100029
  • 收稿日期:2023-11-23 接受日期:2024-01-12 出版日期:2025-02-08 发布日期:2024-06-04
  • 通讯作者: 马金辉，博士，中日友好医院骨科·关节外科，北京市 100029 王佰亮，博士，主任医师，硕士生导师，中日友好医院骨科·关节外科，北京市 100029
  • 作者简介:刘浩洋，男，2000年生，河南省周口市人，汉族，北京大学在读硕士，主要从事骨坏死的相关研究。
  • 基金资助:
    1首都医科大学教育教学改革研究课题(2023JYY388)，项目负责人：马金辉；中2央高水平医院临床科研业务费，中日友好医院“菁英计划”人才培育工程项目(ZRJY2021-TD01)，项目负责人：王佰亮；3国家自然科学基金面上项目(52373273)，项目负责人：王佰亮

Application, research hotspots, and shortcomings of degradable zinc-based alloys in bone defect repair and reconstruction

Liu Haoyang1, Xie Qiang2, Shen Mengran1, Ren Yansong3, Ma Jinhui4, Wang Bailiang4, Yue Debo4, Wang Weiguo4     

  1. 1China-Japan Friendship School of Clinical Medicine, Peking University, Beijing 100029, China; 2Chongqing Medical University, Chongqing 400016, China; 3Health Science Center of Peking University, Beijing 100191, China; 4Department of Orthopedic Surgery, China-Japan Friendship Hospital, Beijing 100029, China
  • Received:2023-11-23 Accepted:2024-01-12 Online:2025-02-08 Published:2024-06-04
  • Contact: Ma Jinhui, MD, Department of Orthopedic Surgery, China-Japan Friendship Hospital, Beijing 100029, China Wang Bailiang, MD, Chief physician, Master’s supervisor, Department of Orthopedic Surgery, China-Japan Friendship Hospital, Beijing 100029, China
  • About author:Liu Haoyang, Master candidate, China-Japan Friendship School of Clinical Medicine, Peking University, Beijing 100029, China
  • Supported by:
    1Research Project on Education and Teaching Reform at Capital Medical University, No. 2023JYY388 (to MJH); 2National High-Level Hospital Clinical Research Funding, Elite Medical Professionals Project of China-Japan Friendship Hospital, No. ZRJY2021-TD01 (to WBL);3 National Natural Science Foundation of China (General Program), No. 52373273 (to WBL) 

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摘要：


文题释义：

锌基合金：是以锌为基础加入其他元素组成的合金，合金中锌元素含量往往大于95%。各常规体系锌基合金具有良好的生物相容性，其中一些锌基合金中的稀土元素因化学性质与元素钙相似，既可以对抗血液中钙离子也可降低材料表面张力，减少植入物与体内组织之间的黏附力，从而拥有抗凝的特殊性能。
骨传导性：是指植入材料支持骨祖细胞和成骨细胞附着的能力，并且允许这些细胞在移植物的三维结构中增殖、生长和迁移。
背景：锌基合金医用植入材料有优异的力学性能、完全可降解性、良好的生物相容性，主要用于骨科植入物、心血管支架、胆管支架、气管支架、神经导管等。
目的：综述可降解锌基合金应用于骨缺损修复的研究进展，展望锌基材料可期研究方向与成果。
方法：检索PubMed、Web of Science、万方及中国知网数据库，选择各数据库建库至2023年6月收录的各类可降解锌基合金用于骨植入材料研究的相关文献，对生物可降解锌基合金的基本特性进行概述，对锌基合金促进骨组织修复作用进行梳理和归纳总结，讨论当前的研究热点与不足。

结果与结论：①锌基合金具备良好的生物相容性，以锌基合金为基体材料，借助支架结构构建技术和涂层优化工艺将有效提高锌基合金的骨传导性，并且使其降解产物具备高效骨诱导性，以调控成骨、破骨细胞的基因表达，促进骨缺损后的修复重建；②然而在锌基合金优化的研究中，涂层工艺相对不足，增材负载技术尚缺乏；③锌基合金拥有良好的机械、生物特性，通过特殊工艺可增加材料的骨传导性、骨诱导性以有效提高其促进骨修复重建能力，并有望进一步实现个性化移植材料的研发。优化涂层与增材负载等技术融合于锌基合金的研究有待进一步探讨。

https://orcid.org/0009-0004-2975-3484(刘浩洋)

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料；口腔生物材料；纳米材料；缓释材料；材料相容性；组织工程

关键词: 锌基合金, 生物可降解材料, 骨移植, 骨缺损, 骨再生, 综述

Abstract:

BACKGROUND: Zinc-based alloy medical implant materials have excellent mechanical properties, complete degradability and good biocompatibility, and are mainly used in orthopedic implants, cardiovascular stents, bile duct stents, tracheal stents, nerve catheters, etc.

OBJECTIVE: To review the research progress of biodegradable zinc-based alloys in bone defect repair and prospect the promising research direction and achievements of zinc-based materials. 
METHODS: After searching PubMed, Web of Science, WanFang Data, and CNKI databases from the establishment of the database to June 2023, various relevant articles on biodegradable zinc-based alloys for bone implant material research were collected. The basic characteristics of biodegradable zinc based alloys were summarized, and the role of zinc-based alloys in promoting bone tissue repair was sorted and summarized. The current research hotspots and shortcomings were discussed.
RESULTS AND CONCLUSION: (1) Zinc-based alloys have good biocompatibility. Using zinc-based alloys as the matrix material, with the help of scaffold structure construction technology and coating optimization process, the bone conductivity of zinc-based alloys will be effectively improved, and their degradation products will have efficient bone induction to regulate the gene expression of osteoblasts and osteoclasts, thereby promoting the repair and reconstruction of bone defects. (2) However, in the research on optimizing zinc-based alloys, the coating process is relatively insufficient, and additive loading technology is still lacking. (3) Zinc-based alloys have excellent mechanical and biological properties. Through special processes, their bone conductivity and osteoinductivity can be increased to effectively improve their ability to promote bone repair and reconstruction, and it is expected to further achieve the development of personalized transplant materials. Further research and development are needed to optimize the integration of coating and additive loading technologies into zinc-based alloys.

Key words: zinc-based lloy, biodegradable material, bone graft, bone defect, bone regeneration, review 

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