中国组织工程研究

中国组织工程研究 ›› 2023, Vol. 27 ›› Issue (32): 5103-5109.doi: 10.12307/2023.597

• 神经组织构建 nerve tissue construction • 上一篇    下一篇

健康成年人反复唾液吞咽测试期间的近红外脑功能成像

彭昕珂1，2，3，贾飞阳1，2，3，刘  静1，2，3，刘红雅1，2，3，周桂娟1，2，3，刘丹妮1，2，3，郁  静1，2，3，周  君1，2，3   

  1. 南华大学衡阳医学院附属第一医院，1康复医学科，2康复医学中心，3康复医学实验室，湖南省衡阳市  421001
  • 收稿日期:2022-08-22 接受日期:2022-10-22 出版日期:2023-11-18 发布日期:2023-03-22
  • 通讯作者: 周君，博士，主任医师，南华大学衡阳医学院附属第一医院，康复医学科，康复医学中心，康复医学实验室，湖南省衡阳市 421001
  • 作者简介:彭昕珂，女，1995年生，湖南省衡阳市人，汉族，硕士，医师，主要从事神经系统疾病相关脑功能成像研究。
  • 基金资助:
    国家自然科学基金项目(82002400)，项目负责人：周桂娟；湖南省自然科学基金项目(2021JJ30617)，项目负责人：刘红雅

Functional brain imaging using near-infrared spectroscopy during the repetitive saliva swallowing test in healthy adults

Peng Xinke1, 2, 3, Jia Feiyang1, 2, 3, Liu Jing1, 2, 3, Liu Hongya1, 2, 3, Zhou Guijuan1, 2, 3, Liu Danni1, 2, 3, Yu Jing1, 2, 3, Zhou Jun1, 2, 3   

  1. 1Department of Rehabilitation, 2Rehabilitation Medicine Center, 3Rehabilitation Laboratory, The First Affiliated Hospital of Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China
  • Received:2022-08-22 Accepted:2022-10-22 Online:2023-11-18 Published:2023-03-22
  • Contact: Zhou Jun, MD, Chief physician, 1Department of Rehabilitation, 2Rehabilitation Medicine Center, 3Rehabilitation Laboratory, The First Affiliated Hospital of Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China
  • About author:Peng Xinke, Master, Physician, 1Department of Rehabilitation, 2Rehabilitation Medicine Center, 3Rehabilitation Laboratory, The First Affiliated Hospital of Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China
  • Supported by:
    the National Natural Science Foundation of China, No. 82002400 (to ZGJ); Natural Science Foundation of Hunan Province, No. 2021JJ30617 (to LHY)

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摘要：

文题释义：
功能性近红外光谱成像技术：神经活动过程中，大脑神经活动区域血流量增加所携带的氧将远超神经活动的耗氧量，而氧通过血液中的血红蛋白进行传输。基于上述神经血管耦合原理，大脑神经活动区域会出现血液中氧合血红蛋白浓度上升、脱氧血红蛋白浓度下降。功能性近红外光谱成像技术正是利用近红外光可穿透脑表面被血红蛋白吸收和散射的原理，进而检测大脑皮质血流量的分布变化。
反复唾液吞咽测试：是一种评估正常人吞咽功能的简单方便的方法，它要求受试者在放松体位且没有外部刺激(如食物或水)的情况下反复吞咽自己的唾液，观察整个过程中的吞咽次数及喉上抬幅度，此过程包含吞咽的口腔期与咽期。

背景：吞咽是一种复杂的运动，吞咽的整个过程需要2个大脑半球皮质、脑干、特定的脑神经和咽部感受器之间的协同参与，而大脑皮质在吞咽过程中的作用及其对吞咽的影响仍然是一个待解决的问题。
目的：使用功能性近红外光谱分析健康成年人反复唾液吞咽测试时大脑皮质的激活及偏侧化情况。
方法：纳入27名健康成年人，其中男13名、女14名，年龄(20.41±1.66)岁，在功能性近红外光谱采集过程中进行反复唾液吞咽测试，分析该任务状态下的脑区激活情况，并计算激活脑区的偏侧化分布。
结果与结论：①在反复唾液吞咽测试任务时，受试者双侧初级躯体感觉皮质、双侧初级运动皮质、双侧运动前区和辅助运动皮质区、双侧额下回三角部、双侧额极区及双侧背外侧前额叶均明显激活。半数以上受试者在反复唾液吞咽测试任务中存在大脑皮质半球的偏侧化，但大脑半球偏侧化存在较大变异性，且与受试者利手无明显关系。②将健康成年人作为受试者探究吞咽有关的激活区，能更准确地了解吞咽过程中的神经活动，对于进一步探究吞咽功能障碍具有重要意义。
https://orcid.org/0000-0002-0881-5760(彭昕珂)

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

关键词: 吞咽, 反复唾液吞咽测试, 功能性近红外光谱成像技术, 脑区激活, 偏侧化

Abstract: BACKGROUND: Swallowing is a complex movement that requires the synergistic involvement between the cortices, brainstem, specific brain nerves and pharyngeal receptors of the two cerebral hemispheres. The role of the cerebral cortex in the swallowing process and its influence on swallowing remain to be solved.
OBJECTIVE: To analyze cortical activation and lateralization during the repetitive saliva swallowing test in healthy adults using functional near-infrared spectroscopy.
METHODS: Twenty-seven healthy subjects, aged (20.41±1.66) years, were enrolled, including 13 males and 14 females. All the subjects underwent the repetitive saliva swallowing test during functional near-infrared spectroscopy measure. The brain regions activated by the task were analyzed and the lateralization index of the activated brain regions was calculated.
RESULTS AND CONCLUSION: During the repetitive saliva swallowing test, the bilateral primary somatosensory cortex, bilateral primary motor cortex, bilateral pre-motor and supplementary motor cortex, bilateral pars triangularis, bilateral frontopolar area, and bilateral dorsolateral prefrontal cortex were significantly activated. More than half of the subjects had cortical hemispheric lateralization in the repetitive saliva swallowing test, but there was greater variability in hemispheric lateralization and no significant association with subject’s handedness. The use of healthy adults as subjects in this study to explore the activated areas associated with swallowing allows us to more accurately understand the neural activity during swallowing, which is important for further investigation of swallowing dysfunction.

Key words: swallowing, repetitive saliva swallowing test, functional near-infrared spectroscopy, brain area activation, lateralization

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