中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (36): 9479-9487.doi: 10.12307/2026.909

• 肌肉肌腱韧带组织构建 tissue construction of the muscle, tendon and ligament • 上一篇    下一篇

低频脉冲磁场对脑卒中偏瘫患者骨骼肌结构的影响及健康促进的潜在机制

李文昊1，孙  泰2，李博阳3，孙世强1，杜欣冉1，王有朋1，白  石4，厉中山1，5   

  1. 1东北大学体育部，辽宁省沈阳市  110819；2辽宁省体育事业发展中心，辽宁省沈阳市  110170；3延边大学体育学院，吉林省延边市  133000；4福建师范大学体育科学学院，福建省福州市  350117；5沈阳工业大学信息科学与工程学院，辽宁省沈阳市  111003
  • 收稿日期:2025-11-29 修回日期:2026-03-10 出版日期:2026-12-28 发布日期:2026-05-22
  • 通讯作者: 厉中山，长聘副教授，沈阳市领军人才，东北大学体育部，辽宁省沈阳市 110819；福建师范大学体育科学学院，福建省福州市 350117
  • 作者简介:李文昊，男，2003年生，东北大学体育部在读硕士，主要从事运动人体科学，磁生物学以及运动促进人体健康研究。
  • 基金资助:
    辽宁省科技计划联合计划(技术攻关计划项目)(173165312852)，项目负责人：厉中山；辽宁省国际合作项目(2023JH2/10700004)，项目负责人：白石；国家自然科学基金项目(62471320)，项目负责人：白石；兴辽人才计划项目
    (XLYC2203046)，项目负责人：白石

Effects of low-frequency pulsed electromagnetic fields on skeletal muscle structure in post-stroke hemiplegic patients and the potential mechanism for health promotion

Li Wenhao1, Sun Tai2, Li Boyang3, Sun Shiqiang1, Du Xinran1, Wang Youpeng1, Bai Shi4, Li Zhongshan1, 5   

  1. 1Department of Physical Education, Northeastern University, Shenyang 110819, Liaoning Province, China; 2Liaoning Provincial Sports Development Center, Shenyang 110170, Liaoning Province, China; 3School of Physical Education, Yanbian University, Yanbian 133000, Jilin Province, China; 4School of Physical Education Sciences, Fujian Normal University, Fuzhou 350117, Fujian Province, China; 5School of Information Science and Engineering, Shenyang University of Technology, Shenyang 111003, Liaoning Province, China
  • Received:2025-11-29 Revised:2026-03-10 Online:2026-12-28 Published:2026-05-22
  • Contact: Li Zhongshan, Associate professor, Department of Physical Education, Northeastern University, Shenyang 110819, Liaoning Province, China; School of Physical Education Sciences, Fujian Normal University, Fuzhou 350117, Fujian Province, China
  • About author:Li Wenhao, MS candidate, Department of Physical Education, Northeastern University, Shenyang 110819, Liaoning Province, China
  • Supported by:
    Liaoning Provincial Science and Technology Plan Joint Program (Technology Breakthrough Program Project), No. 173165312852 (to LZS); Liaoning Provincial International Cooperation Project, No. 2023JH2/10700004 (to BS); National Natural Science Foundation of China, No. 62471320 (to BS); Xing Liao Talent Program Project, No. XLYC2203046 (to BS)

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摘要：



文题释义：
脑卒中偏瘫：是指因脑卒中导致大脑运动皮质或下行运动通路损伤，进而引发的单侧肢体运动功能障碍。
低频脉冲磁场：是一种利用低频、特定强度的脉冲式交变磁场作为能量载体，对生物组织进行非侵入性干预的物理因子治疗技术。

背景：对脑卒中偏瘫患者而言，传统阻力训练虽有效，但对无法耐受主动运动的患者存在应用限制。低频脉冲磁场作为一种被动干预手段，对于此部分脆弱人群的疗效特异性、安全性及可行性尚未明确，特别是缺乏针对脑卒中后肌萎缩形态学改变的影像学客观评估。
目的：评估低频脉冲磁场对于脑卒中偏瘫患者下肢股外侧肌的肌肉结构改善效果。
方法：招募脑卒中偏瘫后下肢有明显肌萎缩症状的患者23例，随机分为接受低频脉冲磁场刺激的试验组与进行假治疗的对照组，试验组12例，对照组11例，试验时长共计4周。试验组患者每隔48 h进行1次15 min的低频脉冲磁刺激干预，对照组在接受常规医疗同时，进行假治疗，干预时点与试验组一致。4周后利用B型超声影像作为评估手段，观察不同组别患者健侧腿与患侧腿的股外侧肌羽状角、肌肉厚度及横截面积结构指标的变化及健、患侧腿差异值变化。
结果与结论：①经过4周的低频脉冲磁场刺激，最终18例患者完成试验，试验组9例，对照组9例，试验组患者的患侧腿肌肉形态3项指标肌肉厚度、羽状角及横截面积的后测值均显著高于试验前测(P < 0.05)，患侧腿肌肉厚度差异值、羽状角差异值及横截面积差异值的后测值显著低于试验前测(P < 0.05)；对照组患侧腿肌肉厚度 (P=0.023)、横截面积 (P=0.006)指标显著高于试验前测，健侧腿横截面积显著性提升 (P=0.001)，健患侧腿肌肉形态3项指标的差异值无显著性变化；②组间对比发现，试验组关于患侧腿肌肉形态的肌肉厚度、羽状角及横截面积 3项指标均显著高于对照组(P < 0.05)，健患侧腿肌肉形态的肌肉厚度、羽状角 及横截面积 3项指标差异值的变化率显著高于对照组(P < 0.05)。结果证实，经过4周的低频脉冲磁场刺激，脑卒中偏瘫患者股外侧肌下肢偏瘫侧腿的骨骼肌结构与形态相关指标均得到显著改善，为使用该技术作为脑卒中偏瘫患者肌萎缩症状改善的运动替代与医疗策略提供了肌组织形态改善的支持依据。
https://orcid.org/0000-0002-9010-609X(厉中山)


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 低频脉冲磁场, 钙调神经磷酸酶, 瞬时受体电位通道1, 过氧化物酶体增殖物激活受体γ共激活因子1α, 骨骼肌形态结构, 脑卒中, 偏瘫, 肌萎缩, 股外侧肌

Abstract: BACKGROUND: For post-stroke hemiplegic patients, traditional resistance training, while effective, has application limitations in those unable to tolerate active exercise. As a passive intervention, the efficacy specificity, safety, and feasibility of low-frequency pulsed electromagnetic fields for this vulnerable population remain unclear, particularly lacking objective imaging assessments of morphological changes in post-stroke muscle atrophy.
OBJECTIVE: To evaluate the improving effects of low-frequency pulsed electromagnetic fields on the muscle structure of the vastus lateralis muscle in the lower limbs of post-stroke hemiplegic patients.
METHODS: Twenty-three patients with obvious symptoms of lower limb muscle atrophy after stroke hemiplegia were recruited and randomly divided into an experimental group receiving low-frequency pulsed electromagnetic field stimulation and a control group receiving sham treatment. There were 12 cases in the experimental group and 11 cases in the control group. The trial lasted for a total of 4 weeks. Patients in the experimental group received a 15-minute low-frequency pulsed magnetic field stimulation intervention every 48 hours, while the control group received sham treatment alongside routine medical care, with intervention time points consistent with the experimental group. After 4 weeks, B-mode ultrasound imaging was used as an assessment tool to observe changes in the structural indicators of the vastus lateralis muscle, including pennation angle, muscle thickness, and cross-sectional area, in both the unaffected and affected legs of patients in different groups, as well as changes in the difference values.
RESULTS AND CONCLUSION: (1) After 4 weeks of low-frequency pulsed electromagnetic field stimulation, 18 patients completed the trial, with 9 cases in the experimental group and 9 cases in the control group. In the experimental group, the post -test values of the three indicators of muscle morphology in the affected leg, including muscle thickness, pennation angle, and cross-sectional area, were significantly higher than the pre-test values (P < 0.05). The difference values for muscle thickness, pennation angle, and cross-sectional area in the affected leg were significantly lower than those before the trial (P < 0.05). In the control group, muscle thickness and cross-sectional area of the affected leg were significantly higher than before the trial, and the cross-sectional area of the unaffected leg significantly increased; however, there were no significant changes in the difference values of the three muscle morphology indicators between the unaffected and affected legs. (2) Inter-group comparison revealed that the experimental group had significantly higher values than the control group for the three indicators of muscle morphology in the affected leg, including muscle thickness, pennation angle, and cross-sectional area (P < 0.05). The rate of change in the difference values for muscle thickness, pennation angle, and cross-sectional area between the unaffected and affected legs was significantly higher in the experimental group than in the control group (P < 0.05). These findings confirm that after 4 weeks of low-frequency pulsed electromagnetic field stimulation, indicators related to skeletal muscle structure and morphology in the affected vastus lateralis muscle of the lower limb were significantly improved in post-stroke hemiplegic patients, providing morphological evidence supporting the use of this technology as an exercise alternative and medical strategy for improving muscle atrophy symptoms in post-stroke hemiplegic patients.

Key words: low-frequency pulsed electromagnetic fields, calcineurin, transient receptor potential channel 1, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, skeletal muscle morphological structure, stroke, hemiplegia, muscle atrophy, quadriceps femoris

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