中国组织工程研究

中国组织工程研究 ›› 2026, Vol. 30 ›› Issue (18): 4771-4781.doi: 10.12307/2026.721

• 组织工程相关大数据分析 Big data analysis in tissue engineering • 上一篇    下一篇

运动干预多发性硬化症的研究热点与主题演变

杨姜茜1，李黄岩1，张业廷1，余佐银2   

  1. 1中国民用航空飞行学院航空体育学院，四川省广汉市  618307；2西华师范大学体育学院，四川省南充市  637000


  • 收稿日期:2025-07-04 接受日期:2025-08-30 出版日期:2026-06-28 发布日期:2025-12-12
  • 通讯作者: 张业廷，博士，副教授，硕士生导师，中国民用航空飞行学院，四川省广汉市 618307
  • 作者简介:杨姜茜，女，2001年生，四川省内江市人，汉族，中国民用航空飞行学院在读硕士，主要从事体育与健康的研究。
  • 基金资助:
    中央高校基本科研业务费专项资金资助(PHD2023-003)，项目负责人：张业廷

Research hotspots and thematic evolution in the field of exercise interventions for multiple sclerosis

Yang Jiangxi1, Li Huangyan1, Zhang Yeting1, Yu Zuoyin2     

  1. 1Aerospace Sport College, Civil Aviation Flight University of China, Guanghan 618307, Sichuan Province, China; 2School of Physical Education, China West Normal University, Nanchong 637000, Sichuan Province, China
  • Received:2025-07-04 Accepted:2025-08-30 Online:2026-06-28 Published:2025-12-12
  • Contact: Zhang Yeting, PhD, Associate professor, Master’s supervisor, Aerospace Sport College, Civil Aviation Flight University of China, Guanghan 618307, Sichuan Province, China
  • About author:Yang Jiangqian, MS candidate, Aerospace Sport College, Civil Aviation Flight University of China, Guanghan 618307, Sichuan Province, China
  • Supported by:
    the Fundamental Research Funds for the Central Universities, No. PHD2023-003 (to ZYT)

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摘要：


文题释义：
多发性硬化症(Multiple Sclerosis，MS)：是一种中枢神经系统慢性炎症性脱髓鞘疾病，患者中枢神经系统内多部位出现髓鞘破坏、脱落，导致神经冲动传导受阻。多发性硬化症的病因尚不明确，可能与病毒感染、自身免疫反应、遗传因素及环境因素等有关，患者常出现视力下降、肢体无力、感觉异常、共济失调等症状。
运动干预(Exercise Intervention，EI)：指的是以科学化、系统化的身体活动方案为核心，用于改善个体身体功能、心理状态或疾病症状的治疗手段。在多发性硬化症患者中，常见干预形式包括有氧运动、抗阻运动与多元训练等，目的是提升神经可塑性、缓解疲劳、增强功能独立性等多方面健康指标。

背景：研究表明，多模式运动训练能够有效地改善中重度行动障碍多发性硬化症患者的耐力性步行能力以及认知加工速度，这种效应似乎同心肺功能的优化存在相关性，但是缺少对这一领域的文献梳理。
目的：通过文献计量学方法探究运动干预多发性硬化症领域的研究热点与主题演变。  
方法：对Web of Science核心合集数据库进行检索，检索式为TS=(“multiple sclerosis”) AND TS=(“physical activity” OR exercise OR sport)，检索语言为英文，利用CiteSpace软件对运动干预多发性硬化症领域3 761篇文献进行可视化分析。 
结果与结论：①运动与多发性硬化研究领域关键词关注点的变化反映出该领域研究从单个学科深入到多个学科交织，从传统疗法朝着数字康复革新转型的趋向；研究热点逐渐从基础免疫学及病程监测转向康复干预和生活质量改善。②主题分类包括干预方式、研究设计方法以及干预指标，并随着现代信息康复手段的发展，虚拟现实、VR游戏以及机器人辅助训练等手段也应用到对多发性硬化症患者的干预研究中，运动干预多发性硬化症正在由经验性操作朝理论引导下的精确化方向转变。③早期研究关注于多发性硬化症的临床表现、常见合并症(如抑郁、疲劳)以及初期的运动干预考察情况；中后期研究着重于运动康复效果的规范化验证，其中随机对照试验和元分析的数量不断增加，同时研究范围扩展到认知障碍、行为调整等方面；最新阶段研究在前期成果基础上，结合虚拟现实等新技术，并采用以患者体验为核心的方法，从而形成全面且有循证依据的治疗策略。其研究主题的发展历程可被划分成4个时期，依次为“宏观效益验证”“理论建模与机制初探”“行为动机建构与参与促进”以及“精准化与技术融合”。该研究为临床上针对多发性硬化症制定运动干预计划提供了理论依据。

https://orcid.org/0009-0002-8449-2331(杨姜茜)


中国组织工程研究杂志出版内容重点：干细胞；骨髓干细胞；造血干细胞；脂肪干细胞；肿瘤干细胞；胚胎干细胞；脐带脐血干细胞；干细胞诱导；干细胞分化；组织工程

关键词: 运动, 多发性硬化症, 运动干预, CiteSpace, 文献计量学

Abstract: BACKGROUND: Studies have indicated that multi-modal exercise training can effectively improve the endurance walking ability and cognitive processing speed of patients with moderate to severe mobility impairments caused by multiple sclerosis. This effect appears to be related to the optimization of cardiorespiratory function; however, there is a lack of literature review in this area.
OBJECTIVE: To identify research hotspots and explore the thematic evolution in the field of exercise interventions for multiple sclerosis through a bibliometric analysis.
METHODS: A literature search was conducted in the Web of Science Core Collection database using the query: TS=(“multiple sclerosis”) AND TS=(“physical activity” OR exercise OR sport), limited to English-language publications. A total of 3 761 articles regarding exercise interventions for multiple sclerosis were included for visualized analysis using CiteSpace.
RESULTS AND CONCLUSION: (1) The evolving landscape of key research domains in exercise and multiple sclerosis demonstrates a notable transition toward interdisciplinary collaboration, marked by a paradigm shift from conventional therapeutic approaches to cutting-edge digital rehabilitation solutions. Current research trends reveal a progressive movement from fundamental immunological studies and disease progression monitoring to more investigations focusing on rehabilitation interventions and quality-of-life enhancements. (2) Thematic classifications encompass three key dimensions: intervention methodologies, research design frameworks, and intervention indicators. Notably, advancements in modern rehabilitation technologies have facilitated the application of virtual reality systems, virtual reality games, and robotic-assisted training protocols as therapeutic interventions for patients with multiple sclerosis. Exercise intervention for multiple sclerosis is shifting from empirical practices toward a more precise, theory-driven approach. (3) Early research focused on the clinical manifestations of multiple sclerosis, common comorbidities (such as depression and fatigue), and the initial examination of exercise interventions. Mid-to-late stage research emphasized the standardized validation of exercise rehabilitation effects, including an increasing number of randomized controlled trials and meta-analyses, while the research scope expanded to cognitive impairment, behavioral adjustment, and other aspects. The latest stage of research, building on previous achievements, combines new technologies such as virtual reality and adopts patient-experience-centered methods, thus forming a more comprehensive and evidence-based treatment strategy. The development of research themes can be divided into four periods: “macro-benefit verification,” “theoretical modeling and initial exploration of mechanisms,” “behavioral motivation construction and participation promotion,” and “precision and technology integration.” This study provides a solid theoretical foundation for the formulation and improvement of exercise intervention plans in clinical practice for multiple sclerosis.

Key words: exercise, multiple sclerosis, exercise intervention, CiteSpace, bibliometrics

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