中国组织工程研究 ›› 2024, Vol. 28 ›› Issue (11): 1762-1766.doi: 10.12307/2024.231

• 生物材料综述 biomaterial review • 上一篇    下一篇

延迟性肌肉酸痛与运动性骨骼肌记忆

白峥嵘1,2,孙  羽3,张振显1,潘诗农2   

  1. 1延安市人民医院CT诊断科,陕西省延安市  716000;2中国医科大学附属盛京医院放射科,辽宁省沈阳市  110000;3锦州医科大学附属第一医院,辽宁省锦州市  121000
  • 收稿日期:2022-12-21 接受日期:2023-04-08 出版日期:2024-04-18 发布日期:2023-07-27
  • 通讯作者: 潘诗农,教授,中国医科大学附属盛京医院放射科,辽宁省沈阳市 110000
  • 作者简介:白峥嵘,女,1985年生,陕西省延安市人,汉族,在读博士,副主任医师,主要从事运动医学和骨肌影像诊断研究。
  • 基金资助:
    陕西省延安市市级重点研发项目(一般项目)(2021YF-08),项目负责人:白峥嵘

Delayed onset muscle soreness and exercise-induced skeletal muscle memory

Bai Zhengrong1, 2, Sun Yu3, Zhang Zhenxian1, Pan Shinong2   

  1. 1Department of CT Diagnosis, Yan’an People’s Hospital, Yan’an 716000, Shaanxi Province, China; 2Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110000, Liaoning Province, China; 3The First Hospital of Jinzhou Medical University, Jinzhou 121000, Liaoning Province, China
  • Received:2022-12-21 Accepted:2023-04-08 Online:2024-04-18 Published:2023-07-27
  • Contact: Pan Shinong, Professor, Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110000, Liaoning Province, China
  • About author:Bai Zhengrong, MD candidate, Associate chief physician, Department of CT Diagnosis, Yan’an People’s Hospital, Yan’an 716000, Shaanxi Province, China; Department of Radiology, Shengjing Hospital, China Medical University, Shenyang 110000, Liaoning Province, China
  • Supported by:
    Key Research & Development Project of Xi’an City (General Project), No. 2021YF-08 (to BZR)

摘要:


文题释义:

延迟性肌肉酸痛(delayed onset muscle soreness,DOMS):运动医学上指运动后肌肉酸痛伴有疲倦、乏力甚至出现肌肉僵硬、痉挛,是影响人们生活质量的主要症状。
运动性骨骼肌记忆:离心运动可以在随后的类似运动中产生的预防或减轻骨骼肌损伤及肌肉酸痛的效果。也被称为重复回合效应(repetitive turn effect,RBE)或者运动性骨骼肌适应、骨骼肌记忆。其特点是减轻延迟性肌肉酸痛,减轻肌肉肿胀及肌肉损伤标志,使肌肉力量和活动范围更快恢复。


背景:不习惯的运动使骨骼肌损伤,但可以产生一种减轻肌肉再损伤减轻疼痛的特定训练效果-肌肉记忆。

目的:基于延迟性肌肉酸痛的病因,综述延迟性肌肉酸痛中骨骼肌记忆的存在及其可能机制,提出防治延迟性肌肉酸痛的新见解。
方法:第一作者以“DOMS,Skeletal muscle memory,Exercise Skeletal muscle adaptation,Repeat turn effect,exercise and autophagy,Autophagy and inflammation”为英文检索词,“延迟性肌肉酸痛,骨骼肌记忆,运动性骨骼肌适应,重复回合效应,运动与自噬,自噬与炎症”为中文检索词,检索PubMed、Embase、Web of Science、中国知网及万方数据库1990年1月至2022年12月发表的相关文献,最终纳入102篇文献进行综述。

结果与结论:目前认为延迟性肌肉酸痛是由于代谢紊乱、机械损伤和氧化应激所致的急性期炎症反应,而运动性骨骼肌记忆具有减轻延迟性肌肉酸痛、减轻运动再损伤的作用,当离心训练的持续时间、频率和强度逐渐增加时,损伤症状可以被最小化,甚至可以避免。因此基于运动性骨骼肌记忆机制,寻找防治或减轻延迟性肌肉酸痛及运动性肌肉损伤的方法是未来的研究方向。综述的主要目的:①明确运动性骨骼肌记忆的存在;②探讨运动性骨骼肌记忆的可能机制,并提出该记忆与骨骼肌自噬的关系;③通过改善骨骼肌自噬水平为延迟性肌肉酸痛的防治提供新策略。

https://orcid.org/0000-0001-5780-9538(白峥嵘)

中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程

关键词: 运动性肌肉损伤, 延迟性肌肉酸痛, 骨骼肌记忆, 骨骼肌适应, 重复回合效应, 运动-自噬, 自噬-炎症

Abstract: BACKGROUND: Unaccustomed exercise triggers skeletal muscle damage, but produces a specific training effect that reduces muscle re-injury to reduce pain - muscle memory.
OBJECTIVE: Based on the etiology of delayed onset muscle soreness, to review the existence and possible mechanism of skeletal muscle memory in delayed onset muscle soreness and to present new insights into the prevention and treatment of delayed onset muscle soreness.
METHODS: The first author searched in PubMed, Embase, Web of Science, CNKI and WanFang databases for relevant literature published from January 1990 to December 2022. The keywords were “DOMS, skeletal muscle memory, exercise skeletal muscle adaptation, repeat turn effect, exercise and autophagy, autophagy and inflammation” in English and Chinese, respectively. A total of 102 articles were finally included for review.
RESULTS AND CONCLUSION: The etiology of delayed onset muscle soreness is currently believed to be an acute inflammatory response due to metabolic disorders, mechanical injury and oxidative stress, while exercise-induced skeletal muscle memory can reduce delayed onset muscle soreness and exercise re-injury. When the duration, frequency and intensity of centrifugal training are gradually increased, symptoms of the injury can be minimized or even avoided. Therefore, based on the mechanism of exercise-induced skeletal muscle memory, it is the future research direction to find more effective ways to prevent and alleviate exercise-induced muscle injury. This review aims to (1) clarify the existence of exercise-induced skeletal muscle memory; (2) explore the possible mechanisms of exercise-induced skeletal muscle memory and propose the relationship between this memory and skeletal muscle autophagy; and (3) provide new strategies for the prevention and treatment of delayed onset muscle soreness by improving the level of skeletal muscle autophagy.

Key words: exercise-induced muscle injury, delayed onset muscle soreness, skeletal muscle memory, skeletal muscle adaptation, repeated bout effect, exercise-autophagy, autophagy-inflammation

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