中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (5): 859-862.doi: 10.3969/j.issn.1673-8225.2012.05.024

• 器官移植基础实验 basic experiments of organ transplantation • 上一篇    下一篇

血氧水平依赖磁共振成像在慢性肾病中的应用*☆

王文娟1，2，郭  燕1，李竹浩1，蔡华崧1，史瑶平1，杨  栋1   

  1. 1中山大学附属第一医院放射科，广东省广州市  510080；2潍坊市人民医院，山东省潍坊市  261041
  • 收稿日期:2011-08-08 修回日期:2011-12-23 出版日期:2012-01-29 发布日期:2012-01-29
  • 通讯作者: 郭燕，主任医师，博士生导师，中山大学附属第一医院放射科，广东省广州市510080 dr.guoyan@163.com
  • 作者简介:王文娟☆，女，1979年生，山东省潍坊市人，汉族，中山大学在读博士，潍坊市人民医院主治医师，主要从事影像诊断方面的研究。wangwj212@sina.com
  • 基金资助:

    广东省科技计划项目(2010B080701067)，课题名称：磁共振DWI、DTI及BOLD功能成像联合评价慢性肾病患者肾脏功能。

Application of blood oxygen level-dependent magnetic resonance imaging in chronic kidney disease

Wang Wen-juan1, 2, Guo Yan1, Li Zhu-hao1, Cai Hua-song1, Shi Yao-ping1, Yang Dong1   

  1. 1Department of Radiology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou  510080, Guangdong Province, China; 2Weifang People’s Hospital, Weifang  261041, Shandong Province, China
  • Received:2011-08-08 Revised:2011-12-23 Online:2012-01-29 Published:2012-01-29
  • Contact: Guo Yan, Chief physician, Doctoral supervisor, Department of Radiology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China dr.guoyan@163.com
  • About author:Wang Wen-juan☆, Studying for doctorate, Attending physician, Department of Radiology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China; Weifang People’s Hospital, Weifang 261041, Shandong Province, China wangwj212@sina.com
  • Supported by:

    Guangdong Science and Technology Program, No.2010 B080701067*

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摘要：

背景：血氧水平依赖的磁共振成像是目前惟一能无创性地监测肾血氧含量的方法。
目的：探讨血氧水平依赖的磁共振成像在评价慢性肾病患者肾血氧水平、反映肾功能状态方面的价值。
方法：对20名健康志愿者和24名慢性肾病患者行肾脏血氧水平依赖的磁共振成像，测量各组肾皮质及髓质的R2*值，并进行统计学分析。
结果与结论：正常肾髓质的R2*值高于皮质(P < 0.05)，双肾比较差异无显著性意义(P >0.05)。慢性肾病患者皮质及髓质的R2*值均高于正常人(P < 0.05)，均与血清肌酐水平呈正相关(r=0.564，P =0.004；r=0.588，P =0.003)。提示血氧水平依赖的磁共振成像可以反映肾脏血氧水平，在评价肾脏的功能状态方面有一定价值。
关键词：血氧水平依赖；慢性肾病；磁共振成像；血清肌酐；肾髓质
doi:10.3969/j.issn.1673-8225.2012.05.024

关键词: 血氧水平依赖, 慢性肾病, 磁共振成像, 血清肌酐, 肾髓质

Abstract:

BACKGROUND: Blood oxygen level-dependent magnetic resonance imaging is a non-invasive method to monitor renal blood oxygen content.
OBJECTIVE: To explore the application of blood oxygen level-dependent magnetic resonance imaging in the evaluation of renal blood oxygen content and renal function.
METHODS: Blood oxygen level-dependent magnetic resonance imaging was used on 20 healthy volunteers and 24 chronic kidney disease patients. The cortical and medullary R2* value were measured and compared in each group.
RESULTS AND CONCLUSION: Normal medullary R2* value was higher than cortical R2* value (P < 0.05). There was no significant difference in bilateral kidney (P > 0.05). Patients with chronic kidney disease had higher cortical and medullary R2* than normal health (P < 0.05). There was a positive correlation between serum creatinine and renal R2* (r=0.564, P =0.004; r=0.588, P =0.003). This research shows that blood oxygen level-dependent magnetic resonance imaging can reflect renal blood oxygen levels, and has certain value in evaluate the renal function.

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