中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (36): 6821-6824.doi: 10.3969/j.issn.1673-8225.2011.36.040

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

自体骨髓干细胞治疗肝硬化基础研究与临床应用现状

邢旎旎，李孝生   

  1. 重庆医科大学第二临床医学院消化内科，重庆市  400010
  • 收稿日期:2011-02-28 修回日期:2011-04-27 出版日期:2011-09-03 发布日期:2011-09-03
  • 通讯作者: 李孝生，硕士，教授，硕士生导师，重庆医科大学第二临床医学院消化内科，重庆市400010 LXS6896@126.com
  • 作者简介:邢旎旎★，女，1979年生，重庆市人，重庆医科大学在读硕士，主要从事肝纤维化防治方面的研究。 nx0912@163.com
  • 基金资助:

    重庆市科委自然科学基金项目(2006B135428)。

Basic and clinical research of autologous bone marrow stem cells in treatment of hepatic cirrhosis

Xing Ni-ni, Li Xiao-sheng   

  1. Department of Gastroenterology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing  400010, China
  • Received:2011-02-28 Revised:2011-04-27 Online:2011-09-03 Published:2011-09-03
  • Contact: Li Xiao-sheng, Master, Professor, Master’s supervisor, Department of Gastroenterology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China LXS6896@126.com
  • About author:Xing Ni-ni★, Studying for master's degree, Department of Gastroenterology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China nx0912@163.com
  • Supported by:

    the Natural Science Foundation of Chongqing Science and Technology Committee, No.2006B135428*

PDF

337

被引次数

10

摘要：

背景：活体肝移植仍面临很多问题：如供体的匮乏、移植后的免疫排异反应及其高额的费用等，因此使其在临床上的开展受到限制。
目的：说明自体骨髓干细胞移植可以分化成熟肝细胞而替代受损的肝脏组织发挥功能，从而改善患者症状，提高患者生活质量。
方法：利用计算机在PubMed、CNKI、万方数据库和维普数据库中检索2000-01/2010-12关于自体骨髓干细胞移植相关文章，在标题和摘要中用“骨髓干细胞；自体骨髓干细胞移植；肝硬化”或“Bone marrow stem cell，autologous bone marrow stem cell，hepatic cirrhosis”为检索词进行检索。选择与骨髓干细胞移植相关的文章内容，同一领域文献选择近期发表或发表在权威杂志文章。初检得到235篇文献，根据纳入标准选择20篇文章进行综述。
结果与结论：通过对自体骨髓干细胞移植从基础研究及临床研究方面的最新进展的了解，说明自体骨髓干细胞移植在对肝硬化的治疗方面前景广阔。

关键词: 骨髓干细胞, 自体骨髓干细胞移植, 肝硬化, 动物实验, 临床研究

Abstract:

BACKGROUND: Liver transplantation is still facing many problems, such as lack of donor livers, immune rejection after transplantation and its high costs, thus making it restricted in clinic application.
OBJECTIVE: To describe autologous bone marrow stem cell transplantation in the clinical stage as one of the most promising technology that autologous bone marrow stem cells can differentiate into mature liver cells to replace the damaged liver functioning, which can improve symptoms and quality of life in patients.
METHODS: A computer-based online search of PubMed database, CNKI, Wanfang database and VIP database was performed for articles regarding autologous bone marrow stem cells to treat hepatic cirrhosis, with the key words of “bone marrow stem cell, autologous bone marrow stem cell transplantation, hepatic cirrhosis” in Chinese and “bone marrow stem cell, autologous bone marrow stem cell, hepatic cirrhosis” in English. Relevant articles published in recent years or in authorized journals were preferred. Repetitive studies were excluded. Finally, 20 articles were included.
RESULTS AND CONCLUSION: Basic and clinical research about autologous bone marrow stem cell transplantation indicate that autologous bone marrow stem cell transplantation has a broad prospect in the treatment of hepatic cirrhosis.

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