中国组织工程研究 ›› 2013, Vol. 17 ›› Issue (20): 3738-3745.doi: 10.3969/j.issn.2095-4344.2013.20.018

• 组织构建综述 tissue construction review • 上一篇    下一篇

透明质酸在骨组织工程研究中的应用现状

毛秋华,徐  普   

  1. 中南大学湘雅医学院附属海口医院•海南省口腔医学中心种植科,海南省海口市  570208
  • 收稿日期:2012-12-01 修回日期:2013-03-03 出版日期:2013-05-14 发布日期:2013-05-14
  • 通讯作者: 徐普,博士,主任医师,硕士生导师,中南大学湘雅医学院附属海口医院?海南省口腔医学中心种植科,海南省海口市 570208 hnxupu@163.com
  • 作者简介:毛秋华★,女,1984年生,江西省新余市人,汉族,2009年南昌大学医学院毕业,在读硕士,主要从事口腔种植的研究。

Application of hyaluronic acid in bone tissue engineering  

Mao Qiu-hua, Xu Pu   

  1. Department of Oral Implantology, Hainan Provincial Stomatology Center, Affiliated Haikou Hospital, Xiangya School of Medicine, Central South University, Haikou  570208, Hainan Province, China
  • Received:2012-12-01 Revised:2013-03-03 Online:2013-05-14 Published:2013-05-14
  • Contact: Xu Pu, M.D., Chief physician, Master’s supervisor, Department of Oral Implantology, Hainan Provincial Stomatology Center, Affiliated Haikou Hospital, Xiangya School of Medicine, Central South University, Haikou 570208, Hainan Province, China hnxupu@163.com
  • About author:Mao Qiu-hua★, Studying for master’s degree, Department of Oral Implantology, Hainan Provincial Stomatology Center, Affiliated Haikou Hospital, Xiangya School of Medicine, Central South University, Haikou 570208, Hainan Province, China

摘要:

背景:用组织工程学方法促进骨组织再生,是近年来骨缺损修复的研究热点。支架材料是骨组织工程研究的重要内容。
目的:分析透明质酸作为骨组织工程支架材料的应用进展。
方法:对CNKI、PubMed数据库进行文献检索,以“透明质酸,骨”为中文检索词、“hyaluronic acid, bone“为英文检索词。提取文献进行透明质酸作为骨组织工程支架材料的应用研究的分析。分析了透明质酸的物理特性,透明质酸在骨组织工程中的应用,以及相关文献的发表情况。
结果与结论:透明质酸是一种重要的细胞外基质,透明质酸及其衍生物有优良的特性,是构建组织工程支架的优良材料,且可作为生长因子及细胞的输送载体。国家自然科学基金是资助透明质酸作为骨组织工程支架材料的应用的相关文献最多的基金,湖北中医学院、解放军总医院、广州中医药大学、华南理工大学发表相关文献较多。近年透明质酸在骨组织工程上的应用研究引起了越来越多的关注,但其临床研究较少。

关键词: 组织构建, 组织构建综述, 骨组织构建, 透明质酸, 透明质酸钠, 骨组织工程, 生长因子, 骨形成蛋白2, 胶原纤维, 骨修复, 载体

Abstract:

BACKGROUND: Using tissue engineering method to promote bone tissue regeneration is a hot research point of bone defect repair in recent years, and scaffold materials are the important content for bone tissue engineering research.
OBJECTIVE: To analyze the application progress of hyaluronic acid used as a tissue engineering scaffold material.
METHODS: The CNKI database and PubMed database were searched with the key words of “hyaluronic acid, bone”. The literatures about the analysis on the application of hyaluronic acid as the tissue engineering scaffold material were selected. The physical characteristics of hyaluronic acid and application of hyaluronic acid in bone tissue engineering were analyzed, as well as the publishing of related literatures.
RESULTS AND CONCLUSION: Hyaluronic acid is an important component of the extracellular matrix, and hyaluronic acid and its derivatives have excellent characteristics, which are the excellent materials for building tissue engineering scaffolds, and can be used as carriers for growth factors and cell delivery. The National Natural Science Foundation of China is the foundation that supports the most literatures on the application of hyaluronic acid used as the tissue engineering scaffold materials. Hubei College of Traditional Chinese Medicine, General Hospital of PLA, Guangzhou University of Chinese Medicine and South Chine University of Technology published most of the relevant literatures. In recent years, the application of hyaluronic acid in the bone tissue engineering has attracted more and more attention, but the research on its clinical application is rare. 

Key words: tissue construction, tissue construction review, bone tissue construction, hyaluronic acid, hyaluronic acid sodium, bone tissue engineering, growth factor, bone morphogenetic protein 2, collagen fiber, bone repair, carrier

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