中国组织工程研究

中国组织工程研究 ›› 2013, Vol. 17 ›› Issue (5): 894-901.doi: 10.3969/j.issn.2095-4344.2013.05.020

• 移植与免疫 transplantation and Immunology • 上一篇    下一篇

生物反馈式人工肛门感知系统的研制及效果

肖 钟，黄宗海，史福军，陈 飞，郭雄波，林晓华   

  1. 南方医科大学珠江医院普通外科，广东省广州市 510280
  • 收稿日期:2012-10-25 修回日期:2012-11-05 出版日期:2013-01-29 发布日期:2013-01-29
  • 通讯作者: 黄宗海，博士，主任医师，教授，博士生导师，南方医科大学珠江医院普通外科，广东省广州市 510280 drhuangzh@yahoo.com.cn
  • 作者简介:肖钟☆，男，1983年生，南方医科大学在读博士，医师，主要从事胃肠道肿瘤的临床研究与微创外科治疗。 xiaozhongmail@sina.com

Development and efficacy of a bio-feedback artificial anal sphincter perception system

Xiao Zhong, Huang Zong-hai, Shi Fu-jun, Chen Fei, Guo Xiong-bo, Lin Xiao-hua   

  1. Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, Guangdong Province, China
  • Received:2012-10-25 Revised:2012-11-05 Online:2013-01-29 Published:2013-01-29
  • Contact: Huang Zong-hai, Doctor, Chief physician, Professor, Doctoral supervisor, Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, Guangdong Province, China drhuangzh@yahoo.com.cn
  • About author:Xiao Zhong☆, Studying for doctorate, Physician, Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, Guangdong Province, China xiaozhongmail@sina.com

PDF

633

被引次数

10

摘要：

背景：人工肛门为治疗肛门失禁开辟了一条新的思路，然而现有的人工肛门没有感知和反馈功能。患者只能通过习惯而不是肠内容物的实际情况排便。因此人工肛门感知和反馈系统的研制是亟待解决的问题。
目的：研制能感知和反馈肠内容物量和压力变化的人工肛门感知系统。
方法：通过实验分别向20只新西兰兔近结肠远端10 cm肠管内注入不同体积的模拟气体、液体、半流体、固体肠内容物，并测量肠管和压力感应套囊的压力变化，分析4种状态肠内容物体积与肠管压力和压力感应套囊压力的关系。
结果与结论：实验结果表明，肠管内压力和套囊压力随肠内容物体积的增加而增大，套囊压力与肠内容物体积和肠管压力在一定范围内成正相关。通过实验证实，该生物反馈式人工肛门感知系统能有效的反映肠内容物的多少和肠内压的变化，是解决人工肛门感知和反馈的有效策略，为生物反馈式智能人工肛门的研制打下基础。

关键词: 器官移植, 移植与免疫, 肛门失禁, 人工肛门括约肌, 压力感应套囊, 压力传感器, 生物反馈, 智能人工肛门, 肠内容物, 肠管压力, 组织构建, 组织工程, 省级基金, 器官移植图片文章

Abstract:

BACKGROUND: Artificial anal sphincter is a new way to treat fecal incontinence. However, present artificial anal sphincter lacks of awareness and feedback function, and patients can control their defecation mainly through their habits rather than the existence of the intestinal contents. Research into an awareness and feedback system is the primary issue in the development of artificial anal sphincter.
OBJECTIVE: To develop a bio-feedback artificial anal sphincter perception system which could perceive and feedback the change in intestinal pressure and the volume of intestinal contents.
METHODS: Twenty healthy New Zealand rabbits were used to test its feasibility, and the experiments were performed on the distal part of proximal colon of the rabbits. The pressure of intestinal canal and pressure sensing cuff were measured after injecting four simulated intestinal contents, including gas, liquid, semi-fluid and solid into the intestinal canal respectively. The relationship between the volume of the four states of intestinal contents and the intestinal canal pressure and the cuff pressure was analyzed.
RESULTS AND CONCLUSION: The results of the experiment showed that the pressure of intestinal canal and pressure sensing cuff was increased with the increasing of the volume of intestinal contents, and the pressure and the volume was positively correlated within a certain range. According to the experiment, the bio-feedback artificial anal sphincter perception system could effectively reflect the change of intestinal pressure and the volume of intestinal contents, and may be an effective strategy to address the awareness and feedback problem of artificial anal sphincter, thereby laying the basis for the research of intelligent bio-feedback artificial anal sphincter.

Key words: organ transplantation, transplantation and immunology, fecal incontinence, artificial anal sphincter, pressure sensing cuff, pressure sensor, bio-feedback, intelligent artificial anus, intestinal contents, intestinal canal pressure, tissue construction, tissue engineering, provincial grants-supported paper, photographs- containing paper of organ transplantation

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