中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (43): 8105-8110.doi: 10.3969/j.issn.2095-4344.2012.43.026

• 生物材料综述 biomaterial review • 上一篇    下一篇

丝素蛋白材料在组织工程中的新进展

谢敏凯，徐月敏   

  1. 上海交通大学附属第六人民医院泌尿外科，上海市 200233
  • 收稿日期:2012-01-07 修回日期:2012-02-16 出版日期:2012-10-21 发布日期:2012-10-21
  • 通讯作者: 徐月敏，博士，主任医师，主任，博士生导师，教授，上海交通大学附属第六人民医院泌尿外科，上海市 200233 xuyuemin@ 263.net
  • 作者简介:谢敏凯☆，男，1985年生，浙江省永嘉市人，汉族，上海交通大学在读博士，主要从事泌尿系统组织工程方面的研究。 xieminkai@ hotmail.com

A new development of silk fibroin scaffolds in tissue engineering

Xie Min-kai, Xu Yue-min   

  1. Department of Urology, Affiliated Sixth People’s Hospital of Shanghai Jiao Tong University, Shanghai 200233, China
  • Received:2012-01-07 Revised:2012-02-16 Online:2012-10-21 Published:2012-10-21
  • Contact: Xu Yue-min, Chief physician, Doctoral supervisor, Department of Urology, Affiliated Sixth People’s Hospital of Shanghai Jiao Tong University, Shanghai 200233, China xuyuemin@263.net
  • About author:Xie Min-kai☆, Studying for doctorate, Department of Urology, Affiliated Sixth People’s Hospital of Shanghai Jiao Tong University, Shanghai 200233, China xieminkai@ hotmail.com

PDF

478

被引次数

10

摘要：

背景：丝素蛋白支架已被建议运用在组织工程骨和软骨重建、肌腱重建、血管重建，神经重建以及膀胱重建等各方面。
目的：总结丝素蛋白作为支架在生物材料和组织工程领域的应用与发展。
方法：由第一作者应用计算机检索PubMed数据库及中国期刊数据库2000年1月至2011年11月有关丝素蛋白支架制备工艺，丝素蛋白支架修饰方法及丝素蛋白在组织工程中的应用等方面的文献。
结果与结论：丝素蛋白具有机械强度高、生物降解性慢、生物相容性良好、制备工艺多样等特点，支持多种细胞黏附、分化和生长，可应用于人工韧带、血管、骨、神经组织等方面。近期以丝素蛋白支架作为载体，通过多种方式添加各种生物制剂，比如各种生长因子和细胞因子，进一步扩大丝素蛋白在组织工程中的应用范围。

关键词: 丝素蛋白, 组织工程, 生物材料, 支架材料, 综述文献

Abstract:

BACKGROUND: Silk fibroin scaffolds have been recommended to use in tissue-engineered bone and cartilage, tendon, vessel, nerve, and bladder.
OBJECTIVE: To summarize the application and current development of silk fibroin scaffolds in the fields of biomaterials and tissue engineering.
METHODS: An online search was conducted by the first author in PubMed database and CNKI database to identify the articles related to silk fibroin scaffold preparation technique, modification of silk fibroin and silk fibroin tissue engineering published from January 2000 to November 2011.
RESULTS AND CONCLUSION: Silk fibroin scaffolds has excellent mechanical strength, slow biodegradability, superior biocompatibility and processability. And they can support various cells to attach, differentiate and grow. The scaffolds have been applied in tissue engineering studies, such as artificial ligament, blood vessels, bone, nerve tissue and so on. To date, diverse biologicals, such as growth factors or cytokines, were incorporated therein silk fibroin scaffolds, to further expand the application range in tissue engineering.

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