中国组织工程研究

中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (3): 539-542.doi: 10.3969/j.issn.1673-8225.2012.03.036

• 生物材料临床实践 clinical practice of biomaterials • 上一篇    下一篇

藻酸盐银联合水凝胶敷料对慢性创面愈合的作用★

葛小静，章宏伟，史京萍，李  倩，胡明玉   

  1. 南京医科大学第一附属医院整形烧伤科，江苏省南京市  210029
  • 收稿日期:2011-07-21 修回日期:2011-10-29 出版日期:2012-01-15 发布日期:2012-01-15
  • 通讯作者: 章宏伟，博士，副主任医师，科主任，南京医科大学第一附属医院整形烧伤科，江苏省南京市 210029 zhanghw1966@yahoo.com.cn
  • 作者简介:葛小静★，女，1985年生，安徽省合肥市人，汉族，南京医科大学在读硕士，主要从事慢性创面愈合的研究。 gexiaojing@ 163.com

Effect of SeaSorb-Ag dressing combined with hydrogel on healing of chronic wound

Ge Xiao-jing, Zhang Hong-wei, Shi Jing-ping, Li Qian, Hu Ming-yu   

  1. Department of Burn and Plastic Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing  210029, Jiangsu Province, China
  • Received:2011-07-21 Revised:2011-10-29 Online:2012-01-15 Published:2012-01-15
  • Contact: Zhang Hong-wei, Doctor, Associate chief physician, Department of Burn and Plastic Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China zhanghw1966@ yahoo.com.cn
  • About author:Ge Xiao-jing★, Studying for master’s degree, Department of Burn and Plastic Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China gexiaojing@163.com

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摘要：

背景：研究发现藻酸盐及水凝胶敷料等均可促进创面愈合，而新型敷料藻酸盐银联合水凝胶敷料，对于难治慢性创面的愈合作用尚不清楚。
目的：观察藻酸盐银联合水凝胶敷料对慢性创面治疗的作用。
方法：选择江苏省人民医院烧伤整形科住院慢性创面患者34例，随机分为2组：治疗组应用藻酸盐银联合水凝胶敷料序贯换药；对照组采用1%磺胺嘧啶银冷霜抹在凡士林纱布上外敷，于治疗后7，10，14，17，21 d进行创面分泌物细菌培养、观察创面愈合情况及速度、药物不良反应、换药时创面痛感、肉芽破坏等情况。
结果与结论：治疗组创面细菌检出率明显低于对照组(P < 0.05)。治疗组创面愈合时间比对照组平均缩短约6 d，创面愈合速度较对照组明显加快(P < 0.05)。两组均无药物不良反应，治疗组创面换药时无明显疼痛感，肉芽组织无明显破坏。提示藻酸盐银联合水凝胶敷料序贯治疗慢性创面具有显著抗菌及促进创面肉芽组织和上皮再生、促进创面愈合的作用，且无不良反应。

关键词: 藻酸盐银敷料, 水凝胶敷料, 慢性创面, 创面愈合, 敷料, 组织工程

Abstract:

BACKGROUND: Studies show that the alginate and hydrogel dressings can promote wound healing. The effects of SeaSorb-Ag dressing combined with hydrogel dressing on healing of refractory chronic wound are still unclear.
OBJECTIVE: To observe the efficacy of SeaSorb-Ag combined with hydrogel dressing on healing of chronic wound.
METHODS: A total of 34 patients were selected from the Department of Burn and Plastic Surgery, Jiangsu Province Hospital from April 2010 to March 2011. All cases were divided into two groups randomly. The treatment group was treated with SeaSorb-Ag dressing and hydrogel dressing sequentially, and the control group was treated with 1% silver sulfadiazine on the vaseline gauze. Secretions extracted from wound were used for bacterial culture at 7, 10, 14, 17 and 21 days after treatment. Healing condition and velocity, adverse drug reactions, wound painfulness, and granulation damage were observed.
RESULTS AND CONCLUSION: The detection rate of wound bacteria in the treatment group was significantly lower than that of the control group (P < 0.01). Wound healing time of the treatment group was shorted in about 6 days compared with the control group. The speed of wound healing in the treatment group was significantly faster than that of the control group (P < 0.05). There were no adverse reactions in both groups. The treatment group had no significant pain and damage to granulation tissue during healing. The sequential treatment of SeaSorb-Ag dressing and hydrogel dressing can promote the regeneration of granulation tissue and epithelial cells, and accelerate wound healing in chronic wound.

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