中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (50): 9457-9461.doi: 10.3969/j.issn.1673-8225.2011.50.036

• 组织构建与中医药 tissue construction and traditional Chinese medicine • 上一篇    下一篇

早期注射丹参酮ⅡA磺酸钠可抑制兔耳增生性瘢痕

张建华，欧斌贤，蒙诚跃   

  1. 广西医科大学第一附属医院烧伤整形外科，广西壮族自治区南宁市  530021
  • 收稿日期:2011-06-19 修回日期:2011-10-13 出版日期:2011-12-10 发布日期:2011-12-10
  • 通讯作者: 蒙诚跃，主任医师，广西医科大学第一附属医院烧伤整形外科,广西壮族自治区南宁市 530021 mcy8060@126.com
  • 作者简介:张建华★，男，1981年生，山东省滨州市人，汉族，2010年广西医科大学毕业，硕士，医师，主要从事危重烧伤治疗和增生性瘢痕防治的研究。 347313009@qq.com
  • 基金资助:

    广西自然科学基金项目(桂科自0728129)，课题名称：应用丹参、川芎嗪防治增生性瘢痕的研究。

Early application of sodium tanshinoneⅡA sulfonate can depress hypertrophic scar of rabbit ear

Zhang Jian-hua, Ou Bin-xian, Meng Cheng-yue   

  1. Department of Burn and Plastic Surgery, First Affiliated Hospital of Gaungxi Medical University, Nanning  530021, Guangxi Zhuang Autonomous Region, China
  • Received:2011-06-19 Revised:2011-10-13 Online:2011-12-10 Published:2011-12-10
  • Contact: Meng Cheng-yue, Chief physician, Department of Burn and Plastic Surgery, First Affiliated Hospital of Gaungxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China mcy8060@126.com
  • About author:Zhang Jian-hua★, Master, Physician, Department of Burn and Plastic Surgery, First Affiliated Hospital of Gaungxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China 347313009@qq.com
  • Supported by:

    the Natural Science Foundation of Guangxi, No. Guikezi0728129*

PDF

496

被引次数

12

摘要：

背景：丹参酮ⅡA磺酸钠具有抗氧化、抑制纤维化等作用。
目的：观察丹参酮ⅡA磺酸钠早期局部注射对兔耳增生性瘢痕的影响。
方法：于兔耳腹侧面切除全层皮肤及软骨膜建立瘢痕模型，造模后28 d，分别在创面瘢痕内注射0.05，0.1，0.2 mg的丹参酮ⅡA磺酸钠或生理盐水，每周注射1次，共3周。
结果与结论：丹参酮ⅡA磺酸钠注射3周，兔耳瘢痕增生较轻，瘢痕厚度变薄；苏木精-伊红染色见瘢痕组织中胶原纤维减少，血管数目减少；Masson染色检测见瘢痕组织胶原纤维分布面积减少；电镜下瘢痕组织成纤维细胞数量减少，体积相对变小。说明早期注射丹参酮ⅡA磺酸钠对兔耳瘢痕增生有抑制作用。

关键词: 兔耳, 增生性瘢痕, 丹参酮ⅡA磺酸钠, 抑制, 组织工程

Abstract:

BACKGROUND: Sodium tanshinoneⅡA sulfonate (STS) play effects on anti-oxidant, and depression of fibration. 
OBJECTIVE: To investigate the effect of early injection of STS on hypertrophic scar (HS) of rabbit ear.
METHODS: Scar model were established by removing the skin and perichondrium in rabbits ears on facies ventralis. STS    0.05 mg, 0.1 mg, 0.2 mg (or 40μl normal saline, respectively, experimental groups), normal saline 40 μL(control group) were injected into early rabbits ears scars, once a week, 3 weeks all together.
RESULTS AND CONCLUSION: After 3 weeks STS injection, the hyperplasia and the thickness were decreased; the quantity of collagen fiber and vascular in scar tissue section was decreased in experimental group detected by hematoxylin-eosin staining. The collagen fiber area in scar tissue section was decreased by Masson staining and the amount and the volume of fibroblast were decreased under electron microscope. That indicated that early STS injection could depress HS in rabbits scar ears.

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