中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (42): 7915-7922.doi: 10.3969/j.issn.1673-8225.2011.42.030

• 生物材料综述 biomaterial review • 上一篇    下一篇

前交叉韧带重建移植材料的研究与进展

赵晓亮，章  莹   

  1. 解放军广州军区广州总医院骨科医院创伤骨科，广东省广州市 510010
  • 收稿日期:2011-03-01 修回日期:2011-04-03 出版日期:2011-10-15 发布日期:2011-10-15
  • 通讯作者: 章 莹，教授，主任医师，解放军广州军区广州总医院骨科医院创伤骨科，广东省广州市 510010
  • 作者简介:赵晓亮★，男，1984年生，陕西省宝鸡市人，汉族，广州中医药大学在读硕士，主要从事中西医结合对骨科、创伤骨科的基础及临床研究。 jiangmanchun_04@qq.com

Research progress of graft materials for anterior cruciate ligament reconstruction

Zhao Xiao-liang, Zhang Ying   

  1. Department of Traumatic Orthopedics, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou  510010, Guangdong Province, China
  • Received:2011-03-01 Revised:2011-04-03 Online:2011-10-15 Published:2011-10-15
  • Contact: Zhang Ying, Chief physician, Professor, Department of Traumatic Orthopedics, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, Guangdong Province, China
  • About author:Zhao Xiao-liang★, Studying for master’s degree, Department of Traumatic Orthopedics, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, Guangdong Province, China jiangmanchun_04@ qq.com

PDF

268

被引次数

6

摘要：

背景：膝关节前交叉韧带重建效果受多种因素影响，包括移植物的选择。
目的：对用于前交叉韧带重建的移植材料的种类、材料性质、相关实验、临床应用等方面的研究进行回顾分析。
方法：由第一作者检索1985/2009 PubMed数据及万方数据库有关前交叉韧带重建的移植材料如自体韧带、同种异体韧带、人工韧带、组织工程韧带、异种韧带等方面的文献。
结果与结论：目前国内外修复前交叉韧带损伤可供选择的移植物有自体组织替代物、同种异体韧带、人工韧带、生物组织工程韧带等。此外还有一些其他生物材料如异种韧带等，目前还处于实验探索及研究阶段。人工合成材料与组织工程韧带近几年研究较多，但其制作工艺复杂，价格昂贵，很难满足临床移植的需要。随着越来越多去抗原处理技术的出现，有效去除异种韧带的免疫原性，提高其组织相容性已不是没有可能，在此基础上异种韧带来源广泛，获取方便、价格低廉、适用性广等优势得以凸显。

关键词: 前交叉韧带, 重建, 移植材料, 人工合成材料, 组织工程

Abstract:

BACKGROUND: The effect of anterior cruciate ligament reconstruction is affected by many factors, including graft choice.
OBJECTIVE: To retrospectively analyze the graft types, material properties, relevant experiments and clinical application in anterior cruciate ligament reconstruction.
METHODS: The first author retrieved PubMed and Wanfang databases (1985/2009) for articles addressing graft materials for anterior cruciate ligament reconstruction, such as autologous ligaments, ligament allograft, artificial ligaments, tissue engineered ligament, and heterogeneous ligaments.
RESULTS AND CONCLUSION: Implants for repairing of anterior cruciate ligament injuries include autologous ligaments, ligament allograft, artificial ligaments, tissue engineered ligament. Furthermore, other materials such as xenografts are underlying testing and feasibility studies. Artificial materials and tissue engineered ligaments are the hotspots in recent years. However, the high-cost and complex process limits the clinical use of these two kinds of implants. With the development of antigen-processing technologies, it is impossible to efficiently eliminate the immunogenicity of heterogeneous tendon/ligament and improve quality of biocompatibility. Xenografts with the good price and rich source are convenient to be obtained and suitable to widespread application in the future.

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