中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (36): 6809-6812.doi: 10.3969/j.issn.1673-8225.2011.36.037

• 干细胞学术探讨 stem cell academic discussion • 上一篇    下一篇

脐血间充质干细胞在软骨组织工程中的应用

王琮仁，张  寿   

  1. 中南大学湘雅海口医院（海口市人民医院）骨科中心，海南省海口市 570208
  • 收稿日期:2011-03-11 修回日期:2011-05-25 出版日期:2011-09-03 发布日期:2011-09-03
  • 通讯作者: 张寿，主任医师，硕士研究生导师，中南大学湘雅海口医院(海口市人民医院)骨科中心，海南省海口市570208
  • 作者简介:王琮仁★，男，1985年生，湖南省长沙市人，汉族，中南大学在读硕士，主要从事骨与关节损伤的研究。 wangcongren1010@sina.com
  • 基金资助:

    海南省自然科学基金项目(309107)；2010海口市重点科技计划项目(2010-168)。

Application of umbilical cord blood mesenchymal stem cells in cartilage tissue engineering

Wang Cong-ren, Zhang Shou   

  1. Department of Orthopedics, Xiangya Haikou Hospital (Haikou People’s Hospital), Central South University, Haikou  5720208, Hainan Province, China
  • Received:2011-03-11 Revised:2011-05-25 Online:2011-09-03 Published:2011-09-03
  • Contact: Zhang Shou, Chief physician, Master’s supervisor, Department of Orthopedics, Xiangya Haikou Hospital (Haikou People’s Hospital), Central South University, Haikou 5720208, Hainan Province, China
  • About author:Wang Cong-ren★, Studying for master’s degree, Department of Orthopedics, Xiangya Haikou Hospital (Haikou People’s Hospital), Central South University, Haikou 5720208, Hainan Province, China wangcongren1010@sina.com
  • Supported by:

    the Natural Science Foundation of Hainan Province, No. 309107*; Haikou Key Science and Technology Porject, No. 2010-168*

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摘要：

背景：关节软骨修复再生能力较差，软骨缺损的修复与功能重建是关节外科的一大难题，也是近年研究热点之一，而软骨组织工程技术的发展为其提供了新的思路和方法。
目的：总结和分析脐血间充质干细胞的生物学特性及其在软骨组织工程中的研究与应用。
方法：通过计算机检索中国期刊全文数据库及PubMed数据库2000-01/2010-12的有关文献资料，分别以“脐血间充质干细胞，组织工程，软骨缺损”为中文检索词，“umbilical cord blood mesenchymal stem cells,tissue engineering,cartilage repair”为英文检索词，纳入脐血间充质干细胞和软骨组织工程的相关文献，排除重复性研究，共选取33篇文献做进一步分析。
结果与结论：脐血间充质干细胞以其固有的取材方便、免疫原性较弱、分化能力强以及被病毒细菌污染率低等特有的优势，成为软骨组织工程理想的种子细胞，将在未来软骨组织工程的研究及应用中发挥重要的作用。

关键词: 脐血间充质干细胞, 诱导分化, 支架材料, 组织工程, 缺损修复

Abstract:

BACKGROUND: Due to the poor repair capacity of articular cartilage, it is still a difficult problem to repair and reconstruct articular cartilage defects in orthopedics, and it is also one of the research foci in recent years. But, the development of cartilage tissue engineering provides a new way for repairing articular cartilage defects.
OBJECTIVE: To conclude and analyze the biological characteristics of umbilical cord blood mesenchymal stem cells and their research and application in cartilage tissue engineering.
METHODS: We searched CNKI and PubMed database for literatures from January 2000 to December 2010. Key words were “umbilical cord blood mesenchymal stem cells, tissue engineering, cartilage repair”. Articles on Umbilical cord blood mesenchymal stem cells and cartilage tissue engineering were included, and repetitive studies were excluded. Finally, 33 articles were selected for further analysis.
RESULTS AND CONCLUSION: Umbilical cord blood mesenchymal stem cells, as ideal seed cells of cartilage tissue engineering, are easy to obtain, and have weak immunogenicity, strong differentiation, low rate of bacterial contamination by viruses and other unique advantages. And it is will play an important role in cartilage tissue engineering.

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