中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (34): 6432-6435.doi: 10.3969/j.issn.1673-8225.2011.34.040

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

组织工程心脏瓣膜支架材料的选择与应用

哈里木•克里木，王  磊，齐  海   

  1. 新疆医科大学第二附属医院心外科，新疆维吾尔自治区乌鲁木齐市  830028
  • 收稿日期:2011-05-25 修回日期:2011-07-16 出版日期:2011-08-20 发布日期:2011-08-20
  • 通讯作者: 齐海，硕士，主任医师，新疆医科大学第二附属医院心外科，新疆维吾尔自治区乌鲁木齐市 830028 jiangwx777@163.com
  • 作者简介:哈里木?克里木，男，1965年生，新疆乌鲁木齐市人，哈萨克族，1991年中山医科大学毕业，副主任医师，主要从事心脏外科专业的研究。 wangjinchui1978@163.com

Selection and application of scaffold materials for tissue engineered heart valves

Halimu•Kelimu, Wang Lei, Qi Hai   

  1. Department of Cardiosurgery, Second Affiliated Hospital of Xinjiang Medical University, Urumqi  830028, Xinjiang Uygur Autonomous Region, China
  • Received:2011-05-25 Revised:2011-07-16 Online:2011-08-20 Published:2011-08-20
  • Contact: Qi Hai, Master, Chief physician, Department of Cardiosurgery, Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, Xinjiang Uygur Autonomous Region, China jiangwx777@163.com
  • About author:Halimu?Kelimu, Associate chief physician, Department of Cardiosurgery, Second Affiliated Hospital of Xinjiang Medical University, Urumqi 830028, Xinjiang Uygur Autonomous Region, China wangjinchui1978@163.com

PDF

314

被引次数

5

摘要：

背景：支架材料的选择在组织工程心脏瓣膜中起着至关重要的作用，支架材料的选择也就影响着组织工程心脏瓣膜的构建效果。
目的：评价组织工程心脏瓣膜支架材料的的优缺点，并对其选择进行总结。
方法：以 “组织工程，心脏瓣膜，支架材料，生物相容性”，为中文关键词；以:“tissue engineering，heart valves, scaffold material, biocompatibility” 为英文关键词，采用计算机检索1993-01/2009-10相关文章。纳入与有关生物材料与组织工程心脏瓣膜的相关的文章；排除重复研究及Meta分析类文章。
结果与结论：人工合成高分子材料有更大的可控性，可预先塑性，大量制备，孔径和孔隙率较容易控制，成本低廉；天然生物材料和合成高分子材料都存在一定不足，将人工可降解材料与天然材料相结合构建瓣膜支架，发挥两者各自的优势构建出性能良好的组织工程心脏瓣膜。组织工程心脏瓣膜的研究前景广阔。但距离临床应用还有很长的路要走，相信随着研究的不断深入以及支架材料的不断优化对组织工程心脏瓣膜构建方法的改进，在不远的将来造福于广大心脏瓣膜病患者。

关键词: 心脏瓣膜, 人工瓣膜, 组织工程, 支架材料, 生物相容性

Abstract:

BACKGROUND: The choice of scaffold materials in heart valve tissue engineering plays a vital role, which affects the construction of tissue-engineered heart valve.
OBJECTIVE: To review the advantages and disadvantages of tissue engineered heart valve scaffold materials.
METHODS: A computer based search was performed for articles about biomaterials and tissue engineered heart valve published from January 1993 to October 2009 with the keywords of “tissue engineering, heart valves, scaffold material, biocompatibility” in Chinese and English. Repetitive studies and Meta analysis were excluded.
RESULTS AND CONCLUSION: Synthetic polymer materials with greater controllability can be pre-plastic. The pore size and porosity of the synthetic polymer materials is easy to control, and the cost is low based on mass production. Natural biomaterials and synthetic polymers have their own shortcomings. Artificial biodegradable materials combined with natural materials can build an excellent tissue-engineered heart valve. The tissue-engineered heart valve has a good prospect, but its clinical application requires further studies. With the development and modification of scaffold materials and preparation methods, tissue engineered heart valves will benefit the majority of patients with heart valve diseases.

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