中国组织工程研究

中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (12): 2257-2260.doi: 10.3969/j.issn.1673-8225.2011.12.041

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

不同类型生物材料的心脏瓣膜应用及安全性评价

陈晓伟，池一凡，牛兆倬，侯文明，孙忠东，孙  勇   

  1. 青岛大学附属医院市立医院心脏外科，山东省青岛市  266000
  • 收稿日期:2010-12-06 修回日期:2011-02-07 出版日期:2011-03-19 发布日期:2011-03-19
  • 通讯作者: 牛兆倬，硕士，主治医师，青岛市市立医院心脏外科，山东省青岛市266000
  • 作者简介:陈晓伟★，男，1982年生，汉族，河北省唐山市人，青岛大学在读硕士，从事专业冠心病的外科治疗方面的研究。

Application and safety evaluation of different types of heart valve biomaterials

Chen Xiao-wei, Chi Yi-fan, Niu Zhao-zhuo, Hou Wen-ming, Sun Zhong-dong, Sun Yong   

  1. Department of Cardiac Surgery, Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao  266000, Shandong Province, China
  • Received:2010-12-06 Revised:2011-02-07 Online:2011-03-19 Published:2011-03-19
  • Contact: Niu Zhao-zhuo, Master, Attending physician, Department of Cardiac Surgery, Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao 266000, Shandong Province, China zz_niu@hotmail.com
  • About author:Chen Xiao-wei★, Studying for master’s degree, Department of Cardiac Surgery, Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao 266000, Shandong Province, China chenxiaowei0409@sina.com

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341

被引次数

3

摘要：

背景: 组织工程心脏瓣膜是应用工程学和生命科学的原理和方法构建具有生理功能和生物活性的瓣膜替代物，但仍处于动物实验阶段。
目的：总结常用的组织工程心脏瓣膜，对不同类型生物材料的心脏瓣膜应用的安全性进行评价。
方法：以“生物材料，心脏瓣膜，支架材料，综述文献，组织工程”为中文关键词，采用计算机检索2000-01/2010-12相关文章。纳入与生物材料与组织工程心脏瓣膜研究相关的文章；排除重复研究或Meta分析类文章。
结果与结论：共纳入生物材料与组织工程心脏瓣膜研究相关文献20篇。天然支架材料因其优越的生物相容性和三维空间构象，具有其他材料不可比拟的仿生性。合成可降解高分子材料具有良好的可控性和力学性能也备受研究者青睐，而将天然材料和高分子材料融合一体构建的复合支架材料为组织工程心脏瓣膜的研究提供了新的策略和方向，具有广阔的应用前景。

关键词: 心脏瓣膜, 生物材料, 支架材料, 组织工程, 综述文献

Abstract:

BACKGROUND: Heart valve tissue engineering is aimed to construct heart valve grafts with the physiological function and biological activity by using engineering and life science principles and methods, but still in the animal experiment stage.
OBJECTIVE: To summarize the commonly used tissue engineered heart valve, and to evaluate the reliability of different types of heart valve biomaterials.
METHODS: Using “biological materials, heart valve, scaffolds, reviews, tissue engineering” in Chinese as the key words, a computer retrieval was performed for articles published from January 2000 to December 2010. Articles regarding the biomaterials in tissue engineered heart valve were included; the duplicated research or meta-analysis were excluded.
RESULTS AND CONCLUSION: A total of 20 papers about the biomaterials and tissue engineering heart valve were screened out. Due to the superior biocompatibility and three-dimensional conformation, natural scaffold materials exhibit unparalleled bionic property compared with other materials. Synthetic biodegradable polymer materials with good mechanical properties and controllability has thus been highly favored by researchers, while the composite scaffold materials of natural materials and polymer materials provides a new strategy and direction for the investigations of tissue engineered heart valve, and has broad application prospects.

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