中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (49): 9277-.doi: 10.3969/j.issn.1673-8225.2010.49.036

• 干细胞学术探讨 • 上一篇    下一篇

骨髓间充质干细胞与运动性膝关节损伤

钟冬红1，陈惠宇2   

  1. 1江西省宜春学院体育学院，江西省宜春市   336000；2山东省菏泽学院体育系，山东省菏泽市   274015
  • 出版日期:2010-12-03 发布日期:2010-12-03
  • 作者简介:钟冬红，女，1968年生，江西省宜春市人，汉族，2000年上海体育学院毕业，讲师，主要从事体育教学与训练的研究。 zzz661018@163.com

Bone marrow mesenchymal stem cells and sports knee injury

Zhong Dong-hong1, Chen Hui-yu2   

  1. 1Physical Culture Institute of Yichun University, Yichun  336000, Jiangxi Province, China; 2Physical Culture Institute of Heze University, Heze  274015, Shandong Province, China
  • Online:2010-12-03 Published:2010-12-03
  • About author:Zhong Dong-hong, Lecturer, Physical Culture Institute of Yichun University, Yichun 336000, Jiangxi Province, China zzz661018@163.com

PDF

307

被引次数

8

摘要：

背景：膝关节损伤是运动损伤中最常见的创伤之一，严重影响了运动员的训练和比赛，其损伤还可造成心血管和代谢的运动适应性减退和失用性肌萎缩。骨髓间充质干细胞以其多向分化潜能、低免疫原性、无排斥反应等优点为其在膝关节损伤的防治领域提供了广阔的应用前景。
目的：总结骨髓间充质干细胞作用于运动性膝关节损伤的应用，旨在为膝关节损伤的预防和治疗提供科学依据。
方法：通过计算机检索PubMed数据库检索1994-01/2010-05的文献资料，以“骨髓间充质干细胞、运动、膝关节损伤” 为中文检索词，以“mesenchymal stem cell，sports, knee injuries” 为英文检索词。纳入骨髓间充质干细胞和运动性膝关节损伤相关文献，排除重复性研究，共选取了34篇论文进行分析讨论。
结果与结论：通过对骨髓间充质干细胞的生理特性、临床应用以及运动性膝关节损伤的原因分析，探讨骨髓间充质干细胞对运动性膝关节软骨、肌腱、肌细胞和半月板损伤的修复作用。结果发现骨髓间充质干细胞以其取材方便、创伤小且易于从骨髓中分离等的优点为修复膝关节软骨损伤、促进其肌腱的修复和治疗膝关节半月板损伤等有极为重要的价值。

关键词: 膝关节损伤, 骨髓间充质干细胞, 运动, 软骨, 肌腱

Abstract:

BACKGROUND: Knee injury is one of the most common sports injuries, and it seriously impacts the athletes training and competition. The injury can also cause cardiovascular and metabolic adaptation to decline and disuse muscle atrophy. Bone marrow mesenchymal stem cells (BMSCs) characterized by pluripotent, low immunogenicity, no rejection of its advantages provide a broad application prospects in prevention and treatment of knee joint injury.
OBJECTIVE: To summarize the application of BMSCs to sports knee injury, and to provide a scientific basis for prevention and treatment of knee injury.
METHODS: We searched PubMed database for literatures published from January 1994 to May 2010. Key words were “bone marrow mesenchymal stem cells, exercise, knee injury”. Articles on BMSCs and exercise knee injury were included, and repetitive studies were excluded. Finally, 34 articles were selected for further analysis.
RESULTS AND CONCLUSION: The repair effect of BMSCs on knee joint cartilage, tendon, muscle cells and meniscus was explored by analyzing physiological characteristics, clinical application of BMSCs and causes of sports knee injury. The results showed that BMSCs for its convenience, less invasive and easy separation from the bone marrow have great values for repairing knee cartilage damage, promoting tendon repair and treating knee joint injury.

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