中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (49): 9263-.doi: 10.3969/j.issn.1673-8225.2010.49.034

• 干细胞学术探讨 • 上一篇    下一篇

骨髓间充质干细胞在肝衰竭中的应用

杨玲玲，何金秋   

  1. 南昌市第九医院(南昌大学附属感染病医院)肝一科，江西省南昌市  330002
  • 出版日期:2010-12-03 发布日期:2010-12-03
  • 作者简介:杨玲玲★，女，1985年生，江西省进贤县人，汉族，南昌大学在读硕士，主要从事骨髓间充质干细胞治疗肝衰竭的研究。 eleanyang2008@163.com

Application of bone marrow mesenchymal stem cells to liver failure

Yang Ling-ling, He Jin-qiu    

  1. First Department of Hepatology, Nanchang Ninth Hospital (Infectious Disease Hospital Affiliated to Nanchang University), Nanchang  330002, Jiangxi Province, China
  • Online:2010-12-03 Published:2010-12-03
  • About author:Yang Ling-ling★, Studying for master’s degree, First Department of Hepatology, Nanchang Ninth Hospital (Infectious Disease Hospital Affiliated to Nanchang University), Nanchang 330002, Jiangxi Province, China eleanyang2008@163.com

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264

被引次数

3

摘要：

背景：近年来诸多研究已经报道了骨髓间充质干细胞在肝脏病理条件下能够分化为具部分功能的类肝细胞且可修复受损肝脏。
目的：总结和分析骨髓间充质干细胞的生物学特性及其在肝衰竭中的研究与应用。
方法：应用计算机检索CNKI和PubMed数据库中1997-01/2009-12关于“骨髓间充质干细胞在肝衰竭中的研究与应用”的文章，以“骨髓间充质干细胞，肝衰竭”或“肝干细胞，肝脏疾病” 为检索词进行检索。选择文章内容与骨髓间充质干细胞治疗肝衰竭相关，同一领域文献则选择近期发表或发表在权威杂志文章。初检得到中英文共371篇文献，根据纳入标准选择31篇文章进行综述。
结果与结论：骨髓间充质干细胞是成体干细胞的一种，其具有高度自我更新能力和多向分化潜能，用于肝衰竭治疗的作用机理主要是转分化和细胞融合。随着研究不断得深入，骨髓间充质干细胞移植已逐渐开展应用至肝衰竭治疗中，但其研究有待进一步完善。

关键词: 肝衰竭, 骨髓间充质干细胞, 来源, 应用, 分离纯化

Abstract:

BACKGROUND: Recent studies have shown that bone marrow mesenchymal stem cells (BMSCs) could differentiate into hepatocyte-like cells in pathologic liver tissue and restore the injured livers. 
OBJECTIVE: To conclude and analyze biological characteristics of BMSCs and their clinical application in liver failure treatment. 
METHODS: We retrieved China National Knowledge Infrastructure (CNKI) and PubMed databases for articles concerning research and application of BMSCs in liver failure treatment published from January 1997 to December 2009. The key words were “bone marrow mesenchymal stem cells, liver failure” or “liver stem cells, liver disease”. The articles addressing BMSCs for liver failure, and the articles published recently or in authorized journals, were included. A total of 371 literatures were primarily selected, and 31 were included in accordance with inclusion criteria.
RESULTS AND CONCLUSION: BMSCs are a type of adult stem cells, which possess an extensive self-renewal potential and ability to differentiate into various cell types. Their ability of repairing the liver failure is by the mechanisms of transdifferentiation and cell fusion. With the development of research, BMSCs transplantation is gradually applied to treatment on liver failure. However, the study deserves further improvement.

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