中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (38): 7217-7220.doi: 10.3969/j.issn.1673-8225.2010.38.046

• 生物材料临床实践 clinical practice of biomaterials • 上一篇    

国产雷帕霉素药物洗脱支架置入治疗急性心肌梗死108例

韩  轶，朱鹏程，吴致安   

  1. 新疆医科大学附属中医医院心内科，新疆维吾尔自治区乌鲁木齐市 830000
  • 出版日期:2010-09-17 发布日期:2010-09-17
  • 通讯作者: 吴致安，副主任医师，新疆医科大学附属中医医院心内科，新疆维吾尔自治区乌鲁木齐市 830000 wza1560@sina.com
  • 作者简介:韩轶，男，1973年生，新疆维吾尔自治区乌鲁木齐市人，汉族，2002年新疆医科大学毕业，主治医师，主要从事心血管方面的研究。xiaochu138@sina.com

Domestic rapamycin-eluted stent for treatment of acute myocardial infarction in 108 cases

Han Yi, Zhu Peng-cheng, Wu Zhi-an   

  1. Department of Cardiology, Traditional Chinese  Medicine Hospital of Xinjiang Medical University, Urumqi  830000, Xinjiang Uygur Autonomous Region, China
  • Online:2010-09-17 Published:2010-09-17
  • Contact: Wu Zhi-an, Associate chief physician, Department of Cardiology, Traditional Chinese Medicine Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China wza1560@sina.com
  • About author:Han Yi, Attending physician, Department of Cardiology, Traditional Chinese Medicine Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang Uygur Autonomous Region, China xiaochu138@sina.com

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摘要：

背景：大量临床实验已证明国产雷帕霉素药物洗脱支架在择期经皮冠状动脉支架置入中应用有较强的安全性和较好的生物相容性，但其应用于急性心肌梗死患者的安全性和有效性目前仍存在较大争议。
目的：观察雷帕霉素药物洗脱支架经皮冠状动脉置入急性心肌梗死患者的效果。
方法：纳入108例急性心肌梗死患者，男61例，女47例，年龄37~81岁，平均(57.2±13.1)岁。所有患者均行经皮冠状动脉支架置入，置入前后常规用药，观察梗死相关动脉TIMI血流结果，6~12个月门诊及电话随访，以心源性死亡、非致死性心肌梗死、靶血管血运重建的发生率为主要终点来判断临床事件。
结果与结论：支架置入后，梗死相关动脉血流TIMI分级为Ⅰ~Ⅱ级6例(5.6%)，Ⅲ级102例(94.4%)；支架置入成功率100%，临床成功率98.1%；支架置入后6，12个月主要不良心脏事件发生率分别为1.87%和3.74%。提示急性心肌梗死患者经皮冠状动脉置入雷帕霉素药物洗脱支架具有良好的安全性和有效性。

关键词: 急性心肌梗死, 疗效, 梗死相关动脉, 经皮冠状动脉, 雷帕霉素, 药物洗脱支架

Abstract:

BACKGROUND: A large amount of clinical trials have demonstrated that the application of domestic rapamycin-eluted stent is safe and biocompatible in selective coronary artery interventional operation. However, its reliability and effectiveness remain controversial when applied on patients with acute myocardial infarction.
OBJECTIVE: To evaluate the therapeutic effect of rapamycin eluted stent via percutaneous coronary implantation on acute myocardial infarction.
METHODS: Emergency percutaneous coronary interventions were applied in 108 cases of acute myocardial infarction by the implantation of domestic rapamycin-eluted stent, all patients including 61 males and 47 females aged 37-81 years with a mean of (57.2±13.1) years received routine medication preoperatively and postoperatively. The improvement of TIMI blood flow of infarction-related artery was rating. Major cardiac events including the incidence of cardiac death, non-fatal myocardial infarction, target vessel revascularization was evaluated in 6-12 months of follow-up in outpatient department or by a call visiting.
RESULTS AND CONCLUSION: After stent implantation, the TIMI blood flow was graded as Ⅰ-Ⅱ in 6 cases (5.6%), as Ⅲ in 102 cases (94.4%). The achievement ratio of implantation is 100%, the clinical success ratio is 98.1%, the incidence of major adverse cardiac events is 1.87% and 3.74% at the sixth month and the twelfth month respectively. The rapamycin-eluted stent is safe and effective in the percutaneous coronary intervention of acute myocardial infarction patients.

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