中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (38): 7189-7192.doi: 10.3969/j.issn.1673-8225.2010.38.039

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

五种不同血管支架材料学特点及置入后的生物相容性

熊  杰1，姜  岩2   

  1. 1武警医学院附属医院中医科，天津市  300162;2武警天津总队医院中医科，天津市  300162
  • 出版日期:2010-09-17 发布日期:2010-09-17
  • 通讯作者: 姜岩，硕士，主治医师，武警天津总队医院中医科，天津市 300162
  • 作者简介:熊杰☆，女，1967年生，天津市人，汉族，天津中医药大学在读博士，教授，主任医师，主要从事心脑疾病的临床与实验研究。drxiongjie@yahoo.com.cn

Material characteristics of five different vascular stents and their biocompatibility after implantation

Xiong Jie1, Jiang Yan2   

  1. 1 Department of Traditional Chinese Medicine, Affiliated Hospital of Medical College of Chinese People’s Armed Police Forces, Tianjin   300162, China; 2 Department of Traditional Chinese Medicine, Tianjin Corps Hospital of Chinese People’s Armed Police Forces, Tianjin   300162, China
  • Online:2010-09-17 Published:2010-09-17
  • Contact: Jiang Yan, Master, Attending physician, Department of Traditional Chinese Medicine, Tianjin Corps Hospital of Chinese People’s Armed Police Forces, Tianjin 300162, China
  • About author:Xiong Jie☆, Studying for doctorate, Professor, Chief physician, Department of Traditional Chinese Medicine, Affiliated Hospital of Medical College of Chinese People’s Armed Police Forces, Tianjin 300162, China drxiongjie@yahoo.com.cn

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421

被引次数

7

摘要：

目的：评价组织工程血管支架材料的性能、相溶性和应用前景。
方法：以“组织工程，支架材料，生物相容性，性能，应用”为中文关键词；以:“tissue engineering, intravascular stent,Biocompability, Performance，Using” 为英文关键词，采用计算机检索1993-01/2009-10相关文章。纳入与有关生物材料与组织工程血管相关的文章；排除重复研究或Meta分析类文章。以26篇文献为主重点进行了讨论组织工程血管材料的种类及其性能。
结果：天然材料支架与细胞亲和性强，能为细胞的生长、增殖、分化及功能发挥提供近似体内的发生发育的细胞外基质支架条件，能使细胞聚集成组织，控制组织结构，调节细胞表型；免疫排斥反应极低，且有良好的顺应性。但机械强度比较差。人工合成聚合物支架具有精确的可操作性，但缺乏细胞外基质中的生物信号和功能基团，与种子细胞的黏附性较差；且在材料降解过程中，会产生一些酸性物质，对局部会产生一定的影响；且缺乏生物信号而不易被细胞识别。此外，提高支架置入后的生物相容性应从血液相容性和组织相容性入手。
结论：虽然现在合成材料成为研究的热点，但是置入后的相溶性并不能很好地符合支架要求，与组织融合，既要有良好的细胞亲和性，又要有与血管相似的力学性能。这就迫切需要新材料的出现，来更好的满足组织化血管支架的要求，达到复和重建的目的。

关键词: 组织工程, 支架材料, 生物相容性, 性能, 应用

Abstract:

OBJECTIVE: To evaluate the performance, compatibility and application prospects of blood vessel tissue engineered scaffolds.
METHODS: Using “tissue engineering, scaffold materials, biocompatibility, performance, application” for the Chinese key words and “tissue engineering, intravascular stent, biocompatibility, performance, using” for the English key words, a computer search was performed between January 1993 and October 2009. Articles related with the biomaterials and tissue engineering blood vessels were included; repeated study or Meta analysis articles were excluded. There are 26 articles mainly discussing the types and properties of tissue engineered vascular materials.
RESULTS: The natural scaffolds have strong affinity with cells, can provide for cell growth, proliferation, differentiation and functioning with similar extracellular matrix scaffold condition as in vivo development, thus aggregating cells into tissues, controlling tissue structure, and regulating cell phenotype; immune rejection is very low, and compliance is good. But mechanical strength is relatively poor. Synthetic polymer scaffold has precise maneuverability, but lacks biological signals and functional groups in extracellular matrix, and poorly adhere to the seed cells; and some acid materials may generate in the degradation process, exhibiting some local effects; biological signals is absent, and the scaffold is not susceptible by cell recognition. In addition, the key to improve the biocompatibility of stents should be the blood compatibility and histocompatibility.
CONCLUSION: Although synthetic materials have become the research hotspot, but the compatibility after implantation are not good enough to met scaffold requirements, a confluence with tissue requires good cell affinity and similar mechanical properties with blood vessels. There is an urgent need for new materials to better meet the requirements of tissue engineered vascular stent and to achieve the purpose of repair and reconstruction.

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