关键词: 经皮冠状动脉成形, 药物血管支架, 血管内膜增生, 再狭窄, 生物相容性

Abstract:

OBJECTIVE: To evaluate the effect and safety of drug-eluting stent implantation in coronary artery interventional therapy.
METHODS: With key words “percutaneous transcoronary angioplasty, drug intravascular stent, intimal hyperplasy, restenosis, biocompatibility”, a computer-based online search was performed for articles published between January 2000 and December 2009. Articles correlated with intravascular stent materials, intravascular stent material modification were included. Repetitive studies or Meta analysis was excluded. Finally, 14 articles were included, and influence of drug-eluting stent on blood vessel endothelium hyperplasy, restenosis, and biocompatibility was discussed.
RESULTS: Drug-eluting stent can control release of drug from polymer coating to vascular lesion sites by eluting pattern. For example, rapamycin-eluting stent effectively reduces incidence of restenosis and cardiovascular events in treating coronary atherosclerotic heart disease, and displays favorable effects in treating diabetes, small vessel disease, coronary artery long lesions and diffuse complex lesion. In addition, domestic rapamycin-eluting stent shows safety compared with foreign stent. However, it has been paid attention whether the interaction of drug-eluted by the stent and the coating can induce thrombus in the stent. Researchers have studied the thrombus mechanism at late stage, intervention of thrombus risks and stent technology to explore safe drug-eluting stent that can reduce restenosis and in-stent thrombus.
CONCLUSION: Drug-eluting stent, such as rapamycin-eluting stent, effectively reduces incidence of restenosis and cardiovascular events in treating coronary atherosclerotic heart disease, with safety and short- and long-term effect.