中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (25): 4745-4750.doi: 10.3969/j.issn.1673-8225.2010.25.046

• 生物材料综述 biomaterial review • 上一篇    

镍钛形状记忆合金的生物相容性及其在骨科的应用

李  强，唐际存   

  1. 桂林医学院附属医院骨科，广西壮族自治区桂林市  541001
  • 出版日期:2010-06-18 发布日期:2010-06-18
  • 作者简介:李 强★，男，1970年生，甘肃省定西市人，汉族，2005年兰州大学毕业，硕士，副主任医师，副教授，研究生导师，主要从事组织工程与生物材料的研究
  • 基金资助:

    广西教育厅资助项目(200810LX462)；广西卫生厅计划课题(Z2008282)。

Biocompatibility and orthopaedic applications of nickel-titanium shape memory alloy

Li Qiang, Tang Ji-cun   

  1. Department of Orthopaedics, Affiliated Hospital of Guilin Medical University, Guilin  541001, Guangxi Zhuang Autonomous Region, China
  • Online:2010-06-18 Published:2010-06-18
  • About author:Li Qiang★, Master, Associate chief physician, Associate professor, Master’s supervisor, Department of Orthopaedics, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China li.q12251970@163.com
  • Supported by:

    the Foundation of Guangxi Educational Committee, No. 200810LX462*; the Research Program of Health Bureau of Guangxi Province, No. Z2008282*

PDF

579

被引次数

6

摘要：

背景：尽管镍钛合金在骨科的应用已有长足的进展，但由于其具有潜在的细胞、组织及器官毒性，在临床应用仍受到很大的限制。
目的：通过阐述镍钛形状记忆合金在骨科的应用情况、存在的问题及针对这些问题现有的解决方法，为该材料在重建外科领域的安全应用提供理论支持。
方法：应用计算机检索Springer全文数据库及中国CNKI期刊数据库。中英文资料检索时间均为2003/2010。分次输入检索词检索文献，所有英文检索词为“nickel-titanium shape memory alloy (NiTi-SMA); corrosion; biocompatibility; modifications; reconstruction”。所有中文检索词为“镍钛合金；腐蚀性；生物相容性；改性；骨科”。纳入与镍钛合金的临床应用、腐蚀性、生物相容性及其远期应用挑战等相关的文献。排除相关度不大和重复性文章。
结果与结论：镍钛合金以其良好的形状记忆性和超弹性在医学上具有特殊的应用价值。但由于从镍钛合金中释放的镍具有细胞毒性，使提高镍钛合金的抗腐蚀性显得尤为重要。对镍钛合金进行改性是目前该领域研究的重点及以后的研究方向。

关键词: 镍钛合金, 腐蚀性, 生物相容性, 改性, 骨科

Abstract:

BACKGROUND: In spite of some good successes of nickel-titanium alloy have been achieved in orthopaedic surgery, there are still serious limitations in clinical application, such as potential leakage of elements and ions, which could be toxic to cells, tissues and organs.
OBJECTIVE: To review the research progress and the exiting problems of nickel-titanium shape memory alloy in orthopaedics and to provide theoretical supports for safe use of the alloy in clinical practice.
METHODS: A computer-based online search of Springerlink and CNKI was performed for articles published between 2003 and 2010 both in Chinese and English. The search was conducted respectively with the key words of “nickel-titanium shape memory alloy (NiTi-SMA), biocompatibility, modifications, orthopaedics”. Researches regarding nickel-titanium shape memory alloy and its properties, clinical applications, corrosion performance, biocompatibility, corrosion resistance by surface/structure modifications and the long-term challenges were included. Irrelevant or repetitive articles were excluded.
RESULTS AND CONCLUSION: Nickel-titanium shape memory alloy has special value in medical field due to favorable shape-memory and superelasticity. However, due to the nickel toxicity, it is of great importance to elevate corrosion resistance of nickel-titanium alloy. The modifications of the alloy are the main focus and direction for further research.

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