中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (25): 4741-4744.doi: 10.3969/j.issn.1673-8225.2010.25.045

• 生物材料学术探讨 biomaterial academic discussion • 上一篇    下一篇

LARS人工韧带重建交叉韧带的临床应用

曾  伟   

  1. 广西体育运动创伤专科医院骨伤科  广西壮族自治区南宁市  530031
  • 出版日期:2010-06-18 发布日期:2010-06-18
  • 作者简介:曾 伟，男，1959年生，广西壮族自治区南宁市人，汉族，1984年广西医科大学毕业，主治医生，主要从事运动创伤诊疗工作。lisa2113@126.com

Clinical application of cruciate ligament reconstruction with LARS artificial ligament

Zeng Wei   

  1. Department of Orthopedics, Guangxi Athletic Injury Specialty Hospital, Nanning   530031, Guangxi Zhuang Autonomous Region, China
  • Online:2010-06-18 Published:2010-06-18
  • About author:Zeng Wei, Attending physician, Department of Orthopedics, Guangxi Athletic Injury Specialty Hospital, Nanning 530031, Guangxi Zhuang Autonomous Region, China lisa2113@126.com

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被引次数

1

摘要：

目的：总结LARS人工韧带重建交叉韧带的临床应用进展。
方法：以“LARS， artificial ligament ，cruciate ligament，reconstructio”为检索词，检索Pub Med数据库(2001-01/2010-05)；以 “LARS，人工韧带，交叉韧带，重建”为检索词，检索中国期刊全文数据库(2001-01/2010-05)，文献检索语种限制为英文和中文。计算机初检得到205篇文献，对检索后纳入的20篇文献进行分析。
结果：目前使用的组织工程人工韧带材料分为天然聚合材料和人工合成聚合材料，主要有胶原、丝蛋白、乳酸乙醇共聚物、聚左旋乳酸等。这些材料都表现出良好的生物相容性，能够促进细胞的黏附、生长、分泌，并能逐渐生物降解。交叉韧带损伤的原因主要是运动性损伤和交通事故，为恢复其功能主要采用手术重建。临床研究表明LARS人工韧带重建后康复快、恢复关节的稳定性，达到较满意的功能恢复效果。
结论：LARS人工韧带重建术近期效果较好，已成为自体材料的良好替代物，适合期望迅速恢复运动能力的运动员。

关键词: 人工韧带, LARS, 交叉韧带, 重建, 生物材料

Abstract:

OBJECTIVE: To summarize the clinical application progress of cruciate ligament reconstruction using LARS artificial ligament.
METHODS: PubMed database (2001-01/2010-05) and CNKI database (2001-01/2010-05) were searched using “LARS, artificial ligament, cruciate ligament, reconstruction” in English and in Chinese as the keywords. The language was limited to English and Chinese. A total of 205 articles were firstly collected, and 20 related studies were analyzed.
RESULTS: Currently used tissue engineered artificial ligament can be divided into natural and synthetic polymeric materials, including collagen, fibroin, lactic acid alcohol copolymer, and poly-L-lactic acid. These materials exhibit excellent biocompatibility, can promote cell adhesion, growth, secretion, and are gradually biodegradable. The major cause of injury of cruciate ligament is sports injury or traffic accident. In order to restore its function, surgical reconstruction is mainly adopted. The clinical results suggest that the reconstruction of cruciate ligament with LARS artificial ligament can accelerate rehabilitation and recover stabilization of knee joint, resulting in satisfactory functional recovery.
CONCLUSION: The LARS artificial ligament leads to good and rapid reconstruction. It seems to be an ideal graft material and is an effective treatment for athletes to resume high physical activity.

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