中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (11): 2010-2013.doi: 10.3969/j.issn.1673-8225.2010.11.028

• 组织构建综述 tissue construction review • 上一篇    下一篇

不同种类组织工程化细胞移植修复关节软骨的损伤

赵智君1，李世和2   

  1. 1昆明医学院第一临床学院，云南省昆明市650031；
    2昆明医学院第一附属医院骨科，云南省昆明市  650032
  • 出版日期:2010-03-12 发布日期:2010-03-12
  • 通讯作者: 李世和，教授，博士生导师，昆明医学院第一附属医院骨科，云南省昆明市 650032
  • 作者简介:赵智君，男，1981年生，重庆市人，汉族，昆明医学院第一临床学院在读硕士，主要从事骨与关节临床及组织工程修复关节软骨损伤方面的研究。 zzjdq@163.com

Repair of articular cartilage injury using tissue-engineered cell transplantation

Zhao Zhi-jun1, Li Shi-he2   

  1. 1First Clinical College of Kunming Medical College, Kunming  650031, Yunnan Province, China;
    2Department of Orthopedics, First Affiliated Hospital of Kunming Medical College, Kunming  650032, Yunnan Province, China
  • Online:2010-03-12 Published:2010-03-12
  • Contact: Li Shi-he, Professor, Doctoral supervisor, Department of Orthopedics, First Affiliated Hospital of Kunming Medical College, Kunming 650032, Yunnan Province, China
  • About author:Zhao Zhi-jun, Studying for master’s degree, First Clinical College of Kunming Medical College, Kunming 650031, Yunnan Province, China zzjdq@163.com

PDF

424

被引次数

2

摘要：

背景：单纯药物治疗不能有效促进关节软骨缺损的愈合;自体软骨来源有限，软骨移植手术也相应受到限制。
目的：分析关节软骨损伤类型及局部微环境的改变，总结近年来国内外组织工程种子细胞移植研究相关进展以及细胞移植修复关节软骨损伤治疗进展。
方法：以Tissue engineering，cell transplantation，articular cartilage defects为检索词，检索Pubmed数据库(1993-01/2008-12)；以组织工程，细胞移植，关节软骨损伤为检索词，检索CNKI数据库(2000-01/2008-12)。文献检索语种限制为英文和中文。纳入与关节软骨损伤以及分类密切相关性研究，组织工程种子细胞移植技术相关性应用研究。排除重复性研究。以种子细胞的存活和迁移，以及移植后关节功能的恢复和不良反应为评价指标。
结果与结论：计算机初检得到201篇文献，根据纳入排除标准，对组织工程细胞移植修复关节软骨损伤的研究进行分析。临床上，创伤性或骨关节炎造成的关节软骨损伤较为常见，关节软骨自身修复能力差，一旦损伤将很难修复。组织工程细胞移植技术的出现为成功治愈关节软骨损伤带来了新的希望。在动物模型和临床研究中，细胞移植治疗关节软骨损伤已经取得良好的修复效果，但这一技术仍有改进的余地。目前的研究集中在如何从技术上改善组织工程3要素，即细胞，生物支架材料和生物活性因子。自体软骨再生仍然是关节软骨缺损修复的理论支柱，但进一步的研究需要优化其再生效果以及维持更加稳定的软骨细胞表型等等。组织工程细胞移植修复关节软骨损伤疗效较好，随着目前组织工程研究的深入，细胞移植修复技术有望成为临床上治疗关节软骨损伤的新方法。

关键词: 细胞移植, 软骨组织工程, 关节软骨损伤, 修复, 综述文献

Abstract:

BACKGROUND: Simple medication therapy can not promote the healing of articular cartilage defects effectively; the insufficient sources of autogenous cartilage also limited cartilage transplantation. 
OBJECTIVE: The types of articular cartilage injury and local micro-environment changes were analyzed to summarize the progress of tissue engineered seed cell transplantation and cell transplantation therapy for repairing articular cartilage injury.
METHODS: The databases of PubMed database (http://www.ncbi.nlm.nih.gov/sites/entrez/) and CNKI (http://www.cnki.net/) were retrieved with the key words of “Tissue engineering, cell transplantation, articular cartilage defects”, and the literature was limited to English and Chinese languages. Studies concerning articular cartilage injury or was closely related to tissue engineered seed cells transplantation were included. Repetitive studies were excluded. Survival and migration of seed cells, as well as the recovery of joint function and adverse reactions were served as evaluation index.
RESULTS AND CONCLUSION: A total of 201 literatures were seized by computers, according to the inclusion criteria, papers concerning tissue engineering cells for repairing articular cartilage injury were analyzed. Clinically, articular cartilage damage was commonly resulted by traumatic arthritis, which is difficult to repair due to the poor self-repair capacity of articular cartilage. The emergence of tissue engineered cell transplantation brought new hope for articular cartilage injury healing. Cell transplantation has obtained good effects in articular cartilage repair, but the technology is still room for improvement. How to technically improve the tissue-engineered 3 elements, namely, cells, scaffold materials, and biological activity factors were the research focuses. Autologous cartilage regeneration was the theoretical support for articular cartilage defects repairing, which needs to optimize its regeneration and to maintain a more stable chondrocyte phenotype in further research. The tissue-engineered cells had received good effects in repairing articular cartilage injury, and it is expected to be a new clinical treatment for articular cartilage injury with the in-depth study of tissue engineering.

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