中国组织工程研究

中国组织工程研究 ›› 2010, Vol. 14 ›› Issue (3): 509-512.doi: 10.3969/j.issn.1673-8225.2010.03.031

• 生物材料综述 biomaterial review • 上一篇    下一篇

微量元素与钛基种植体微弧氧化陶瓷膜生物活性的关系

王健平1，李星海2，孟祥才3，刘  杰1，王  静3，卢艳萍1　   

  1. 1佳木斯大学口腔医院，黑龙江省佳木斯市  154004；2大兴安岭松岭区人民医院，黑龙江省大兴安岭市  165012；3佳木斯大学，黑龙江省佳木斯市  154007　
  • 出版日期:2010-01-15 发布日期:2010-01-15
  • 通讯作者: 卢艳萍，硕士，主治医师，佳木斯大学口腔医院，黑龙江省佳木斯市 154004
  • 作者简介:王健平★，男，1959年生，黑龙江省集贤县人，汉族，1989年武汉大学毕业，硕士，主任医师，主要从事牙体牙髓病的治疗与研究。 WJP.1959@163.com

Effect of microelement on the bioactivity of micro-arc oxidation ceramic coating on Ti-based implant

Wang Jian-ping1, Li Xing-hai2, Meng Xiang-cai3, Liu Jie1, Wang Jing3, Lu Yan-ping1   

  1. 1 Stomatology Hospital of Jiamusi University, Jiamusi   154004, Heilongjiang Province, China; 2 Songling District People’s Hospital, Daxinganling  165012, Heilongjiang Province, China; 3 Jiamusi University, Jiamusi   154007, Heilongjiang Province, China
  • Online:2010-01-15 Published:2010-01-15
  • Contact: Lu Yan-ping, Master, Attending physician, Stomatology Hospital of Jiamusi University, Jiamusi 154004, Heilongjiang Province, China
  • About author:Wang Jian-ping★, Master, Chief physician, Stomatology Hospital of Jiamusi University, Jiamusi 154004, Heilongjiang Province, China WJP.1959@163.com

PDF

582

被引次数

26

摘要：

背景：微弧氧化又称微等离子体氧化或阳极火花沉积，是一种直接在有色金属表面原位生长陶瓷膜层的新技术。所形成的生物活性涂层具有耐腐蚀性能高、耐磨损性能好等特点，能在植入体表面产生一层多孔、粗糙的氧化膜，改善骨界面的生物学反应，影响骨形成细胞的数目、类型、细胞产物和基质的表达，有利于新骨的生成。
目的：主要观察骨与种植体的骨结合界面整合情况，分析不同金属元素对成骨标志物——碱性磷酸酶的诱导作用。
方法：应用计算机检索PubMed数据库、中国期刊全文数据库1995/2009关于微弧氧化膜中微量元素与新生骨方面的内容。英文关键词为“micro-arc oxidation ,synosteosis ,titanium ,magnesium”；中文关键词为“碱性磷酸酶，钛种植体，生物活性涂层，微弧氧化，微量元素锌”。同时手工检索与微弧氧化及微量元素有关的书籍。共检索96篇文献，排除研究目的与本研究无关和内容重复的34篇，出版时间较长的28篇，保留34篇中英文文献进一步分析。
结果与结论：目前在钙磷盐电解液中引入金属微量元素采用微弧氧化方法在钛种植体表面制备生物活性涂层方面已探索出一条较有潜力的方法，但这一方法尚处于动物实验阶段，在进入临床应用之前，对这一方法的可行性尚需进一步研究。

关键词: 微弧氧化, 骨整合, 碱性磷酸酶, 微量金属元素, 膜生物材料

Abstract:

BACKGROUND: Micro-arc oxidation, also be known as micro-plasma oxidation or anodic spark deposition, is a new technology that can in situ grow ceramic coating directly on the surface of non-ferrous metals. And the ceramic coating has such characteristics as high corrosion resistance, good wear resistance, etc. It is advantageous to the osseointegration between implant and bone that the ceramic coating is able to produce porous, rough oxide film on the surface layer of the implant, which improves the biological reaction of the bone interface so as to affect the number of bone-forming cells, type, products of cell, and the expression of the product.
OBJECTIVE: To observe the osseointegration between bone and implant, and to analyze induced action of metal trace elements to bone-formation’s marker (ALP).
METHODS: A computer-based online search was conducted in PUMMED and Chinese Journal Full-text Database with the key words of “micro-arc oxidation, synosteosis, titanium, magnesium” in both English and Chinese between 1995 and 2009. Additionally, hand-made retrieval was performed for articles about micro-arc oxidation and microelement. Among 96 articles, 34 references were excluded due to unrelated and duplicated articles, and 28 ones were excluded due to long-term publication, 34 ones were included in the final analysis.
RESULTS AND CONCLUSION: It is believed that the surface modification methods on microelement and micro-arc oxidation ceramic coating on Ti-based implant will become the mainstream process to improve the rate of implant-bone integration. However, the clinical application still needs to be further studied.

中图分类号: