Table of Content

16 July 2015, Volume 19 Issue 30 Previous Issue    Next Issue

For Selected:

Download Citations EndNote Reference Manager ProCite BibTeX RefWorks

Toggle Thumbnails

Select

Gelatin-chitosan-hydroxyapatite-minocycline biomimetic nanocomposite materials for repair of rabbit radius defects Li Guang-yu, Dong Zhou, Liu Xin, Tang Jian 2015, 19 (30):  4757-4763.  doi: 10.3969/j.issn.2095-4344.2015.30.001 Abstract ( 292 )   PDF (1667KB) ( 265 )   Save  BACKGROUND: Gelatin-chitosan-hydroxyapatite-minocycline biomimetic nanocomposite materials were developed in our previous studies OBJECTIVE: To observe the capability of gelatin-chitosan-hydroxyapatite-minocycline biomimetic nanocomposite materials in the repair of rabbit radius defects. METHODS: Thirty healthy adult New Zealand rabbits were selected to make critical-size lacunar bone defects of the upper radius (15 mm×6 mm). Then, the rabbit models were randomized into experimental group (n=15), autogenous bone graft group (n=10) and blank group (n=5). Gelatin-chitosan-hydroxyapatite-minocycline biomimetic nanocomposite materials were implanted into radial bone defects in the experimental group. Bone defect in blank group was implanted without any materials; in the autogenous bone graft group, the contralateral radius with same length was taken and implanted into the defect. General observation, histological observation and X-ray observation were performed respectively at 2, 4, 8, 12 weeks postoperatively. RESULTS AND CONCLUSION: At 12 weeks after operation, the experimental group showed obvious new blood vessels at the defect region, complete bony union and disappearance of the composite implant, but lamellar bone structure appeared, small blood vessels were visible, the edge of new bone was connected to the original bone edge, exhibiting a continuity of bone, the bone density was slightly lowered, and the defect region became unobvious. In the autogenous bone graft group, bony union and trabecular bone reconstruction were distinct, the lamellar bone became mature, the medullary cavity was recanalized, the fracture line disappeared completely, and the bone density was completely consistent with that of the original bone. In the blank group, there was no obvious bone formation, which led to bone nonunion, and there were a great amount of fiber tissues and inflammatory cell infiltrated. To sum up, the gelatin-chitosan-hydroxyapatite-minocycline biomimetic nanocomposite material can obviously promote the repair of critical-size bone defects, and the repairing effect is basically the same with that of autologous bone grafting. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

Binding capacity of nano-hydroxyapatite/polyamide composite material on the interface of artificial humeral head Liu Yong, Huang Wei 2015, 19 (30):  4764-4768.  doi: 10.3969/j.issn.2095-4344.2015.30.002 Abstract ( 305 )   PDF (980KB) ( 232 )   Save BACKGROUND: Nano-hydroxyapatite/polyamide 66 is a new nanobionic composite material and has good biocompatibility and bone conduction, but after implantation, whether the composite material can bind to vertebral bone interface and whether it is safe in clinical use still need further studies. OBJECTIVE: To observe the ability of nano-hydroxyapatite/polyamide composite binding to the interface of artificial humeral head. METHODS: The rabbits were randomly divided into two groups: composite group was implanted with nano-hydroxyapatite/polyamide composites; control group implanted with autologous bone. After the replacement, rabbit bone marrow mesenchymal stem cells were subjected to primary culture, and then the cells were co-cultured with the composite material. RESULTS AND CONCLUSION: At 24 hours after culture, bone marrow mesenchymal stem cells grew well on the composite materials. The cell adhesion rate was significantly higher in the composite group than the control group at 1 and 4 hours after culture (P < 0.05). After co-culture 4.5, 5.5, 6.5 hours, the absorbance value of cells in the composite group was higher than that in the control group (P < 0.05). At 24 weeks after replacement, changing ranges in the proportions of bone tissue and fibrous layers on the implant surface as well as coverage rate in the composite group were the highest (P < 0.05). These findings indicate that the nano-hydroxyapatite/ polyamide composite implant has a certain binding capacity, which can make a good interface osseointegration. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

In vivo osteogenic capability of nano-hydroxyapatite/polyamide composite material Xu Xian-chun, Wang Zhi, Hou Tie-qi 2015, 19 (30):  4769-4773.  doi: 10.3969/j.issn.2095-4344.2015.30.003 Abstract ( 336 )   PDF (744KB) ( 380 )   Save BACKGROUND: As a bone reconstruction material, nano-hydroxyapatite has good biocompatibility and osteoconduction, but the clinical use of nano-hydroxyapatite alone still has many deficiencies. OBJECTIVE: To explore the in vivo osteogenic capability of nano-hydroxyapatite/ polyamide composites. METHODS: Twenty-four New Zealand white rabbits were subjected to humeral head replacement using nano-hydroxyapatite/polyamide composite material. X-ray observation and histological observation were done at 3, 6, 12, 24 weeks after replacement. RESULTS AND CONCLUSION: (1) X-ray observation: No thinned cortical bone and ectopic ossification occurred on the upper end of the composite material at different time, and the nano-hydroxyapatite/polyamide material had no signs of fragmentation. The cortical bone around the composite material was fuzzy, and the bone mineral density was increased with time. (2) Histological observation: At 3 weeks after replacement, a large number of cells could be visible, including mesenchymal stem cells and mononuclear macrophages. At 6 weeks after replacement, a large amount of fibrous tissues, fibroblasts and mononuclear macrophages still existed in the boundary membrane, but chondrocytes and osteoblasts distributed less. At 12 weeks after replacement, a wide range of original trabecular bone began to form and were mostly flat that arranged regularly. At 24 weeks after replacement, the boundary membrane was full of bone cells, but the cells on the surface of trabecular bone were relatively regular and primitive cells in the bone tissue began to transform into the lamellar bone. These findings indicate that the nano-hydroxyapatite/polyamide material has good osteogenic capability 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | Related Articles | Metrics

Select

Application of nano-hydroxyapatite/collagen/poly(L-lactide) in posterolateral lumbar spine fusion: safety and effectiveness Mao Li-chuan 2015, 19 (30):  4774-4777.  doi: 10.3969/j.issn.2095-4344.2015.30.004 Abstract ( 418 )   PDF (846KB) ( 283 )   Save BACKGROUND: Bone grafting is often needed in posterolateral lumbar spinal fusion, but bone mass is often not enough to finish this operation. Part of the autologous iliac bones from patients are needed to take as supplement. OBJECTIVE: To investigate the safety and effectiveness of application of nano-hydroxyapatite/collagen/ poly(L-lactide) for posterolateral lumbar spine fusion. METHODS: The clinical data of 52 patients with lumbar degenerative disease who had received the treatment in Meishan Orthopedics Hospital of Sichuan Province, China during February 2013 to February 2014 were retrospectively analyzed. The patients all received posterolateral lumbar spine fusion with bone grafts made of autologous iliac bone particles and nano-hydroxyapatite/collagen/poly(L-lactide). RESULTS AND CONCLUSION: Among the 52 patients, wound healing by primary intention occurred in 51 patients, increased skin temperature, skin swelling, pains and fluid leaking were not observed. The lumbar spine function and pain symptoms of patients all improved to different degrees after internal fixation, The posterolateral lumbar spine fusion rate was 13%, 54% and 84% at 3, 6 and 12 months after internal fixation respectively, and there was no pseudarthrosis. During the 12 months of follow-up period, no screw loose or displacement , adjacent segment slippage or displacement were observed in any patient. These results suggest that the application of nano-hydroxyapatite/collagen/poly(L-lactide) for posterolateral lumbar spine fusion can achieve good results. The nano-hydroxyapatite/collagen/poly(L-lactide) bone graft material is highly biocompatible and safe. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

Nano copper/low-density polyethylene intrauterine device reduces post-implantation uterine bleeding and pain Liu Juan-ni, Yan Fei-yan, Wang Yan 2015, 19 (30):  4779-4783.  doi: 10.3969/j.issn.2095-4344.2015.30.005 Abstract ( 308 )   PDF (832KB) ( 470 )   Save BACKGROUND: Intrauterine device made of bare copper can release a great amount of oxides that are easy to cause bleeding and pain in women. Nano copper/low-density polyethylene intrauterine device can well solve the above drawbacks, which is conducive to the maintenance of the reproductive health of women of childbearing age. OBJECTIVE: To explore the effect of nano copper/low-density polyethylene intrauterine device on post-implantation uterine bleeding and pain. METHODS: A total of 98 voluntary women asking for intrauterine device insertion were selected and randomized into control group (n=49) with 220C (TCu220C) T type copper intrauterine device and observation group (n=49) with nano copper/low-density polyethylene intrauterine device. All the women were followed up for 12 months, and incidence of adverse events, including uterine bleeding and pain, was observed and compared between the two groups. RESULTS AND CONCLUSION: During the follow-up, there were one case of uterine bleeding and two cases of pain in the observation group and the incidence of adverse events was 6%; in the control group, there were five cases of uterine bleeding and eight cases of pain, and the incidence of adverse events was 27%. There was a significant difference in the incidence of adverse events between the two groups (P < 0.05). These findings indicate that the nano copper/low-density polyethylene intrauterine device can effectively reduce the occurrence of uterine bleeding and pain after implantation. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

In vitro corrosion resistance of titanium abutment and different alloys Huang Wei-cheng, Wu Ze-jian, Chen Wei-sheng 2015, 19 (30):  4784-4789.  doi: 10.3969/j.issn.2095-4344.2015.30.006 Abstract ( 333 )   PDF (1116KB) ( 252 )   Save BACKGROUND: Except for mechanical properties and physical and chemical properties, corrosion resistance testing is necessary for a variety of biomedical materials applied in the oral environment to ensure the biocompatibility of materials. OBJECTIVE: To explore the corrosion resistance of titanium abutment and different titanium alloys in vitro. METHODS: Corrosion environment by in vitro artificial saliva was constructed with pH=6.0 at (37±0.5) ℃. Potentiodynamic polarization technique, scanning electron microscope and X-ray diffraction methods were employed to assess the corrosion resistance of titanium alloy, gold alloy, nickel-chromium alloy, and titanium abutment immersed in the artificial saliva for 24 hours. RESULTS AND CONCLUSION: Different alloys had different steady-state potentials, and the range of passivation region was the largest for gold alloy, followed by titanium abutments and titanium alloys, and the smallest for nickel-chromium alloy. After 24 hours of immersion in the artificial saliva, passivation films appeared on the surface of different materials. under the scanning electron microscope, the nickel-chromium alloy surface showed obvious traces of corrosion and there were a large number of large-diameter deep pits, but no corrosion occurred on the surface of the remaining three kinds of alloys; on the surface of nickel-chromium alloy, the contents of chromium, molybdenum and aluminum were decreased, and the contents of nickel and oxygen were increased, but there were still no changes on the surface of the remaining alloys. Cr2O3 was found on the surface of nickel-chromium alloy, TiO2 was generated on the surface of titanium abutment and titanium alloy, but Au and Pt still existed in a single phase on the surface of gold alloy. These findings indicate that titanium alloy and titanium abutment have similar corrosion resistance that is inferior to the gold alloy, but better than the nickel-chromium alloy. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

Biocompatible comparison of two different attachment-retained complete dentures in mandibular edentulous patients  Guo Hao-yong 2015, 19 (30):  4790-4794.  doi: 10.3969/j.issn.2095-4344.2015.30.007 Abstract ( 306 )   PDF (854KB) ( 263 )   Save  BACKGROUND: Precision attachment has been used in complete denture in mandibular edentulous patients because of its strong retention, higher masticatory efficiency, and prevention of alveolar bone resorption. Among them, magnetic attachment and ball-cap attachment are commonly applied for mandibular complete denture. OBJECTIVE: To compare the clinical treatment effects of magnetic attachment and ball-cap attachment-retained complete denture used in mandibular edentulous patients. METHODS: This study included 50 patients with dentition defects, 28 males and 22 females, aged from 40 to 82. And they were randomly divided into two groups (n=25 in each) and treated with magnetic attachment and ball-cap attachment retention of mandibular removable partial denture. Masticatory function was tested after 6 months of wearing denture, and the satisfaction of patients and the periodontal health of abutments were surveyed after 2 years of wearing denture.  RESULTS AND CONCLUSION: After 6 months of wearing denture, two groups had both higher masticatory efficiency, but no significant differences between two groups were found. After 2 years of wearing denture, the retention conditions and comfortable satisfaction of the magnetic attachment group was significantly higher than that of the ball-cap attachment group (P < 0.05). The gingival index, sulcus bleeding index and abutment mobility in the magnetic attachment group were significantly lower than those in the ball-cap attachment group (P < 0.05). And the alveolar bone height of the magnetic attachment group was significantly higher than that of the ball-cap attachment group (P < 0.05). Experimental results indicate that the mandibular restoration complete denture with magnetic attachment shows superiority in retention than with ball-cap attachment. The magnetic attachment provides better retention and better protection for periodontal tissue compared with the ball-cap attachment. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

Zirconia all-ceramic crown and porcelain fused to metal crown for dental defects: an 8-month follow-up of periodontal conditions Hu Fang 2015, 19 (30):  4795-4799.  doi: 10.3969/j.issn.2095-4344.2015.30.008 Abstract ( 298 )   PDF (853KB) ( 308 )   Save  BACKGROUND: Zirconia all-ceramic crown restoration has good biocompatibility and corrosion resistance, and has little irritation to the human periodontal tissue. OBJECTIVE: To compare the clinical curative effects of zirconia all-ceramic and porcelain fused to metal crowns in the repair of dental defects. METHODS: Twenty patients (120 teeth) scheduled for crown lengthening+crown repair were enrolled, including 7 males and 13 females, aged 19-60 years, and then randomly divided into observation group and control group. In the observation group, zirconia all-ceramic crown was used; and in the control group, porcelain fused to metal crown was used. Periodontal conditions, coordination of gingival margin height, and crown edge concealment were compared between the two groups at 8 months after restoration. RESULTS AND CONCLUSION: At 8 months after restoration, the observation group had better periodontal conditions and crown edge concealment than the control group (P < 0.05), and the time of wearing a temporary crown and recovery time were also shorter in the observation group than the control group (P < 0.05). There was no significant difference in the gingival margin height between the two groups at 1, 3 and 8 months after restoration. These findings indicate that after crown lengthening, the zirconia all-ceramic restoration for dental defect repair has better therapeutic effects than the porcelain fused to metal restoration, which can have better marginal adaptation, improve crown edge concealment, reduce gingivitis, decrease plaque adhesion ability, and preferably maintain the periodontal health. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

Effect of 60Co irradiation and trace element zinc on implant-bone fusion Chen Hai-jun, Zhang An-sheng, Zhu Xiao-chun, Qian Qi-chun, Yu Shu-xiang, Yang Bo-cheng, Zhang Jing-bo, Nan Fu-qing, Lin Jun-zhou 2015, 19 (30):  4800-4804.  doi: 10.3969/j.issn.2095-4344.2015.30.009 Abstract ( 186 )   PDF (909KB) ( 267 )   Save BACKGROUND: Zinc supplementation can accelerate implant-bone fusion. OBJECTIVE: To observe the effect of 60Co irradiation and trace element zinc on implant-bone fusion. METHODS: A total of 36 adult male rabbits were involved. One piece of titanium implant was placed into the proximal end of the rabbit’s bilateral tibial heads respectively to set up the animal model with titanium implants. Then the animals were randomly divided into four groups. Twenty-four hours after implantation, 10 g/L zinc sulfate was administered intramuscularly to the animals in the zinc supplement group at the dose of 4 mg/kg, once per day; 9 g/L normal saline was administered intramuscularly to the animals in the control group at the dose of 4 mg/kg, once per day. The animals in the 60Co irradiation group received 60Co irradiation at 2, 4, 6 days at the dose of 15 Gy per day, and 24 hours after implantation, 9 g/L normal saline was administered  intramuscularly at the dose of 4 mg/kg, once per day; while those in the 60Co irradiation and zinc supplement group received 60Co irradiation at 2, 4, 6 days at the dose of 15 Gy per day, and 24 hours after implantation, 10 g/L zinc sulfate was administered intramuscularly to the animals at the dose of 4 mg/kg, once per day. The animals were killed at 1, 4, 12 weeks after treatment. Stereomicroscope was used to observe the histomorphology on the implant-bone interface. RESULTS AND CONCLUSION: Compared to other groups, at the same time, more fibroblasts and fibrous fusion were observed around the implants from the 60Co irradiation group while less bone tissue, especially mature bone tissue, was observed. On the contrary, at the same time, the surfaces of the implants from the zinc supplement group showed more osteoblasts and bone fusion. Mature bone tissue was observed around the implants at the 4th week after implantation indicating that zinc supplement can accelerate the new bone formation on the implant-bone interface at 1-4 weeks after treatment to facilitate the fusion between the implant and bone. The implants from the 60Co irradiation and zinc supplement group showed more bone fusion than those from the 60Co irradiation group at the 4th and 12th weeks, indicating that after 60Co irradiation, zinc supplement still can promote the fusion between the implant and bone. Taken together, these results demonstrate that the appropriate amount of zinc supplemented after irradiation therapy can alleviate the negative effects of irradiation on the implant-bone fusion. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

Temporary protection of cracked teeth using orthodontic band and resin temporary crown Nie Er-min, Jiang Rui, Zhang Chun-yuan, Zeng Jin-di, Tan Ji-zhou 2015, 19 (30):  4805-4809.  doi: 10.3969/j.issn.2095-4344.2015.30.010 Abstract ( 441 )   PDF (588KB) ( 559 )   Save BACKGROUND: In the comprehensive treatment of cracked teeth, the temporary protection using the orthodontic band and resin temporary crown can effectively prevent tooth fracture and protect the cracked teeth with a higher clinical success rate. OBJECTIVE: To evaluate the differences in clinical efficacy of orthodontic band and resin temporary crown on the temporary protection of cracked teeth. METHODS: Totally 189 patients (97 males and 92 females, aged 19-65 years) with cracked teeth were selected, randomly divided into two groups and respectively underwent the temporary protection to cracked teeth with the orthodontic band (n=93) and resin temporary crown (n=96) in the comprehensive treatment. Retention effect, periodontal status and patient satisfaction were observed. RESULTS AND CONCLUSION: There were three cases with loose band and one case with falling band in the group of orthodontic band; there were two cases with falling band in the group of resin temporary crown. No significant difference between two groups in the retention effect was found. There were 11 cases of gingivitis or exploring hemorrhage in the group of orthodontic band and 2 cases in the group of resin temporary crown, indicating the periodontal status in the group of resin temporary crown was better than that in the group of orthodontic band (P < 0.05). There were 18 cases of lower satisfaction for poor color, expand feeling caused by the rubber band and discomfort caused by the band protruding from tooth surface in the group of orthodontic  band; there were 3 cases of lower satisfaction in the group of resin temporary crown, and the patient satisfaction in the group of resin temporary crown were higher than that in the group of orthodontic band (P < 0.05). There is a better clinical effect in the temporary protection to cracked teeth by using the resin temporary crown, especially in the terms of  retention effect, periodontal status and patient satisfaction. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

Application of ultrashort implant in limited alveolar bone of the posterior maxilla Huang Na, Li Ping, Li An, Dai Jing-tao, Wang Yuan-qin, Tang You-chao 2015, 19 (30):  4810-4814.  doi: 10.3969/j.issn.2095-4344.2015.30.011 Abstract ( 366 )   PDF (676KB) ( 429 )   Save BACKGROUND: Research on rough-surfaced implants has demonstrated similar survival rates for short and conventional-length implants. It is not clear whether ultrashort implant in limited alveolar bone of the posterior maxilla can achieve good clinical results. OBJECTIVE: To evaluate the clinical effect of ultrashort implants in limited alveolar bone of the posterior maxilla. METHODS: Eighteen patients with 21 ultrashort implants in limited alveolar bone of posterior maxilla (the mean residual alveolar height=3.19 mm) were included in the study, including 10 males and 8 females, aged 25-68 years. At 12 months after restoration, the patients were detected with cone-beam CT to evaluate the osseointegration and marginal bone level around the implant. RESULTS AND CONCLUSION: All the 18 patients completed the 12-month follow-up, and the 21 pieces of implants had good osseointegration. No soft tissue inflammation was found. At 12 months after restoration, the marginal bone height in the mesial and distal was (-0.21±0.78) mm and (-0.16±0.55) mm, respectively. Implant marginal bone changes in the mesial and distal had no statistical difference (P > 0.05). Ultrashort implants in limited alveolar bone of the posterior maxilla can have good osseointegration, maintain the marginal bone mass around the implant, but still need long-term clinical observation. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

Effect of heparin slow-release stent on angiogenesis and cardiac function of patients with acute myocardial infarction Zhang Jin-ru, Wang Dong-mei 2015, 19 (30):  4815-4819.  doi: 10.3969/j.issn.2095-4344.2015.30.012 Abstract ( 438 )   PDF (964KB) ( 250 )   Save BACKGROUND: Bare-metal stent for treatment of myocardial infarction may improve cardiac function to some extent, but it is prone to induce thrombus. OBJECTIVE: To explore the effect of heparin slow-release stent on angiogenesis and cardiac function of patients with acute myocardial infarction. METHODS: A total of 87 patients with acute myocardial infarction were enrolled, including 47 males and 40 females, aged 55-81 years. These patients were divided into observation group (n=45) with percutaneous coronary intervention with heparin slow-release stent and control group (n=42) with percutaneous coronary intervention with bare metal stent. The follow-up period was 12 months, and angiogenesis, cardiac function improvement and adverse cardiac events in the two groups were observed and compared. RESULTS AND CONCLUSION: The new blood vessel density, myocardial survival area and left ventricular ejection fraction were all higher in the observation group than the control group (P < 0.05). At 3 months after intervention, there was one case of revascularization and one case of recurrent acute myocardial infarction in the observation group; in the control group, there was case of revascularization, one case of recurrent acute myocardial infarction and one case of sudden cardiac death, and there was no difference between the two groups. These findings indicate that that percutaneous coronary intervention with heparin slow-release stent has good biocompatibility and can effectively promote the regeneration of blood vessels and improve cardiac function of patients with acute myocardial infarction. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程   Figures and Tables | References | Related Articles | Metrics

Select

Preparation and self-assembly process of fibrillar collagen sponges Zhao Ying, Lu Jin-ting, Deng Chao, Ren Wei-ye, Chen Jing-hua 2015, 19 (30):  4820-4826.  doi: 10.3969/j.issn.2095-4344.2015.30.013 Abstract ( 438 )   PDF (1147KB) ( 258 )   Save BACKGROUND: An ideal scaffold material needs appropriate degradation rate and certain mechanical properties, but the traditional collagen sponge scaffold has rapid degradation velocity and low mechanical strength, which is easy to collapse and difficult to maintain its natural form. Traditional cross-linking methods also have the problems of cytotoxicity or collagen denaturation, severely limiting the application of collagen. OBJECTIVE: To design a new cross-linking method for collagen and to optimize the self-assembly process so as to develop a collagen sponge scaffold with good mechanical properties and resistance to degradation. METHODS: Collagens were modified by self-assembly technology to prepare collagen fibrils which were then freeze-dried into fibrillar collagen sponges. Meanwhile, we optimized the conditions of self-assembly by using orthogonal experiment based on univariate analysis of the effect of initial collagen mass concentration, final phosphate concentration and pH value on the conversion yield of collagen self-assembly. RESULTS AND CONCLUSION: We optimized the conditions of self-assembly revealed that the optimum  conditions to prepare collagen fibrils were determined as pH=8.0, initial collagen concentration=2 mg/mL, and final concentration of phosphate=15 mmol/L. The results of scanning electron microscope showed that fibrillar collagen sponges were characterized by refined porous structure which was connected by collagen fibrils. In addition, the fibrillar collagen sponges showed better equilibrium-swelling ratio, water retaining property and mechanical strength compared with unmodified collagen spondages (P < 0.05), to solve the problems in rapid degradation. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

Clinical effects of gelatin sponge infiltrated by mouse nerve growth factor in local treatment of peripheral nerve injury Li Li-jun, Shi Yu-bo, Zong Qiang, Zhu Fu-liang, Ni Dong-kui 2015, 19 (30):  4827-4831.  doi: 10.3969/j.issn.2095-4344.2015.30.014 Abstract ( 281 )   PDF (826KB) ( 276 )   Save BACKGROUND: Several studies have attempted to apply mouse nerve growth factor to local lesions of peripheral nerve and found that local injection of mouse nerve growth factor can promote nerve recovery, which is superior to systematic application. OBJECTIVE: To evaluate the clinical effects of gelatin sponge infiltrated by mouse nerve growth factor in the repair of peripheral nerve injury. METHODS: Thirty-six patients with single peripheral nerve injury, including 16 males and 20 females, aged 18-48 years, were randomly divided into two groups: 18 patients in case group underwent debridement and neuroanastomosis, and then the injured nerve was wrapped by gelatin sponge which was infiltrated by mouse nerve growth factor and followed by plaster fixation, anti-inflammatory therapy, neurotrophy and circulation improvement therapy; the other 18 patients in control group were treated only with debridement and neuroanastomosis and other conventional therapies. At 4 weeks after treatment, electrophysiological examination was performed. In addition, sensory and motor function of the distal end of injured nerve was evaluated at 6 months after treatment. RESULTS AND CONCLUSION: Sensory evoked potential and motor evoked potential showed that the recovery rate was 78% (n=14) and 83% (n=15) respectively in the case group, while 57% (n=10) and 66% (n=12) in the control group. There was significant difference between the two groups (P < 0.05). The total effective rate was 94.4% (n=17) in the case group and 83.3% (n=15) in the control group, which were statistically better in the case group than the control group (P < 0.05). These findings indicate that it is significantly effective to treat peripheral nerve injury by gelatin sponge infiltrated by mouse nerve growth factor that has good biocompatibility. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

Polyvinyl alcohol/hydroxyapatite composite hydrogel for the repair of articular cartilage defects: a histocompatibility study Lei Zhi-jian 2015, 19 (30):  4832-4836.  doi: 10.3969/j.issn.2095-4344.2015.30.015 Abstract ( 233 )   PDF (5647KB) ( 523 )   Save BACKGROUND: Hydroxyapatite and polyvinyl alcohol composite hydrogel used for the repair of cartilage defects can have good biological activity in the cartilage joints, effectively promote the growth of bone cells, and enhance the stability and biological activity of implant materials. OBJECTIVE: To explore the histocompatibility of polyvinyl alcohol/hydroxyapatite composite hydrogel transplantation for the repair of articular cartilage defects. METHODS: Twenty New Zealand rabbits were enrolled and randomly divided into control group (n=6) and experimental group (n=14). Unilateral knee cartilage defect models were constructed in the two groups. No treatment was done in the control group, and polyvinyl alcohol/hydroxyapatite composite hydrogel transplantation was performed in the experimental group. After 4, 8, 12 weeks, the animals were killed to collect knee joint specimens for gross observation and histological observation. RESULTS AND CONCLUSION: The surface of articular cartilage in the control group was not recovered at 12 weeks after operation, and granulation tissues were full of cartilage defects. In the experimental group, the  polyvinyl alcohol/hydroxyapatite composite hydrogel was filled in the defects, and tightly connected with the surrounding cartilage tissues with clear boundary and no cell ingrowth at 4 weeks after operation. Until the 12th week, in the experimental group, the composite hydrogel was white and translucent with smooth surface. There was a clear boundary between the composite hydrogel and surrounding cartilage tissues, a great amount of cartilage cells proliferated in the interface that tightly bound to the surrounding tissues, and osteoid tissue grew. These findings indicate that the polyvinyl alcohol/hydroxyapatite composite hydrogel has good histocompatibility in the repair of cartilage defects of rabbit knee joints. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

Biocompatibility of polytetrafluoroethylene combined with type I collagen as a nose filler material Yin Zhong-pu, Sun Xiao 2015, 19 (30):  4837-4841.  doi: 10.3969/j.issn.2095-4344.2015.30.016 Abstract ( 268 )   PDF (4574KB) ( 248 )   Save BACKGROUND: Polytetrafluoroethylene (PTEE) as a nose filler material has advantages on the resistant to corrosion, chemical stability and so on. However, its linear expansion coefficient is large easily leading to infection and rejection, and its application has some limitations. OBJECTIVE: To compare the cell toxicity, inflammatory infiltrates and biocompatibility indexes in vivo between PTEE and PTEE combined with type I collagen. METHODS: MTT method was used to detect the relative proliferation rate of L929 cells cultured with PTEE extract or PTEE combined with type I collagen extract; an electron microscope was used to observe the cell growth. PTEE or PTEE combined with type I collagen was embedded under the nasal dorsal fascia of New Zealand white rabbits for 7 days, and hematoxylin-eosin staining was used to detect whether nasal mucosa epithelial tissue had inflammatory infiltration. Systemic toxicity, allergies, pyrogen reaction and deaths of rabbits were observed after injection of two kinds of material extracts by ear vein. RESULTS AND CONCLUSION: The cytotoxicity and inflammatory infiltration were milder in PTEE combined with type I collagen group than PTEE group (P < 0.05). The allergic reactions and pyrogen reactions were fewer in PTEE combined with type I collagen group than PTEE group (P < 0.05). These findings indicate that PTEE  combined with type I collagen as the nose filler material has better biocompatibility.  中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

Effect of poly-L-lactic acid/amorphous calcium phosphate scaffold on the surrounding tissue calcification after implantation into the rats Qin Chao-shi, Li Xiao-yan, Feng Gao-ke, Jiang Xue-jun, Lu Zhao, Li Jun 2015, 19 (30):  4842-4848.  doi: 10.3969/j.issn.2095-4344.2015.30.017 Abstract ( 461 )   PDF (3022KB) ( 284 )   Save Abstract BACKGROUND: Novel fully biodegradable poly-L-lactic acid/amorphous calcium phosphate (PLLA/ACP) scaffold shows a good prospect of application, but whether the scaffold material has impact on the surrounding tissue calcification is unknown. OBJECTIVE: To observe the influence of PLLA/ACP scaffold material on the calcification of surrounding tissue after implantation of PLLA/ACP scaffold into rats. METHODS: A total of 48 SD rats were divided into experimental group and control group randomly. The experimental group was implanted with PLLA/ACP scaffold material, while the control group was implanted with PLLA scaffold material. At 1, 2, 4, 12 weeks after implantation, the liver function, kidney function and concentrations of calcium, phosphorus, alkaline phosphatase in serum were detected; the muscle tissue around the scaffold was collected for hematoxylin-eosin staining, Von Kossa staining, alkaline phosphatase staining and immunohistochemical staining of nuclear factor-kappa B. Then, western blot assay was used to detect the contents of interleukin-6, bone morphogenetic protein-2, and meanwhile, the contents of calcium and alkaline phosphatase in tissue homogenate were measured. RESULTS AND CONCLUSION: There was no significant difference in either group about the liver and kidney functions at each time. The content of interleukin-6 in the experimental group was less than that in the control  group at 2, 4 and 12 weeks after implantation (P < 0.05). The positive expression of nuclear factor-kappa B, bone morphogenetic protein-2 and inflammatory cell count in the experimental group were less than those in the control group at 4 and 12 weeks after implantation (P < 0.05). The content of calcium in the experimental group was less than that in the control group at 12 weeks after implantation (P < 0.05). No difference was found in the expression of alkaline phosphate, the Von Kossa staining and the content of calcium, phosphorus, alkaline phosphatase in the muscle tissue around the scaffold between the two groups (P > 0.05). These findings indicate that the PLLA/ACP scaffold has a good biocompatibility and biological security, which cannot induce peripheral tissue calcification.  中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

iocompatibility of a cervical dilating rod made of absorbent polymer materials Lu Yao, Hao Ying-ying, Xia Chun-ling, Yang Qing 2015, 19 (30):  4849-4854.  doi: 10.3969/j.issn.2095-4344.2015.30.018 Abstract ( 414 )   PDF (303KB) ( 345 )   Save BACKGROUND: YOUMET cervical dilating rod is made of absorbent polymer materials and has non-toxic side effects, which can avoid cross-infection in one-time use. OBJECTIVE: To observe the clinical effects of YOUMET cervical dilating rod used for cervical orifice dilation before intrauterine device insertion and removal as well as before artificial abortion operations.  METHODS: Totally 275 female subjects schedule for cervical dilation during intrauterine device insertion and removal operations, and suction abortion for pregnancy within 10 weeks were randomly divided into two groups: 137 were included in observation group in which YOUMET cervical dilating rods were applied and 138 were included in control group in which Gongshuning glue sticks were used. Their cervical softening and dilatation situation, analgesic effect, and combined reactions during operation were observed. RESULTS AND CONCLUSION: Between the two groups, no statistical significance in general biological characteristics was found; Dilating effects in intrauterine device removing operations during child-bearing period and menopause were better in the observation group than the control group (P < 0.05). Rates of pain during insertion were higher in the observation group than the control group (P < 0.05). Rates of pain during indwelling period for both groups were comparatively low, which showed no statistical significance. There was no record related to the application of cervical orifice dilating products in postoperative follow-up visit. Both products were safe with no cervical injury, slow heart rate and drop in blood pressure. YOUMET cervical dilating rod has trustworthy and safe dilating effects, which can remarkably alleviate pain. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

Anti-adhesion effect of chitosan and sodium hyaluronate in obstetric patients:      a biocompatibility comparison Fan Yang-yang, Song Yu-long 2015, 19 (30):  4855-4859.  doi: 10.3969/j.issn.2095-4344.2015.30.019 Abstract ( 399 )   PDF (885KB) ( 339 )   Save BACKGROUND: Chitosan and sodium hyaluronate are two kinds of anti-adhesion materials commonly used, but there are relatively few reports on their anti-adhesion effects in obstetrics patients. OBJECTIVE: To explore the anti-adhesion effects of chitosan and sodium hyaluronate in obstetric patients. METHODS: Totally 180 cesarean section patients, aged 23-39 years, were equally divided into control group, chitosan group and sodium hyaluronate group according to treatment methods. Patients in the control group were given the routine cesarean section; patients in the chitosan and sodium hyaluronate group were respectively given local smearing of chitosan and hyaluronate sodium. At 1 day after operation, the levels of serum interleukin-6, interleukin-10, tumor necrosis factor-α and C-reactive protein were determined in the three groups. Then, the patients were followed up for 1 month to observe the occurrence of postoperative adhesion and complications. RESULTS AND CONCLUSION: The incidence rate of postoperative adhesions was lower in the chitosan and sodium hyaluronate groups than the control group (P < 0.05). The levels of serum interleukin-6, interleukin-10, tumor necrosis factor-α and C-reactive protein were also lower in the chitosan and sodium hyaluronate groups than the control group (P < 0.05). In addition, the incidence rates of postoperative infection, bleeding and pain were lower in the chitosan and sodium hyaluronate groups than the control group (P < 0.05). However, there was no difference between the chitosan and sodium hyaluronate groups. These findings indicate that the chitosan and sodium hyaluronate are both effective against postoperative adhesions in cesarean section patients, and reduce the incidence of complications. 生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程   Figures and Tables | References | Related Articles | Metrics

Select

Biocompatibility of titanium alloy and stainless steel internal fixation materials in the treatment of spinal tuberculosis  Chen Xin, Huang Ya-juan, Tian Qian, Xue Chao, Li Hao-peng 2015, 19 (30):  4860-4864.  doi: 10.3969/j.issn.2095-4344.2015.30.020 Abstract ( 323 )   PDF (710KB) ( 435 )   Save BACKGROUND: Titanium alloy and stainless steel are two common internal fixation materials, but there are some difference in their therapeutic effects and biocompatibility. OBJECTIVE: To explore the therapeutic effects and biocompatibility of titanium alloy and stainless steel internal fixation materials for the treatment of spinal tuberculosis. METHODS: Seventy-one spinal tuberculosis patients, 35 males and 36 females, aged 17-81 were enrolled. Among them, 35 patients received titanium alloy internal fixation, and the 36 patients underwent stainless steel internal fixation. At the end of 12-month follow-up, Cobb angle changes, therapeutic effect and Frankel grade were analyzed in the two groups. RESULTS AND CONCLUSION: Before treatment, there was no difference in the spinal kyphosis angle and Frankel grade between the two groups. At the last follow-up, the Frankel grade and Cobb angle were both improved in the two groups (P < 0.05), but there was still no difference between the two groups. The cure rate was 97% (n=34) in the titanium alloy group and 92% in the stainless steel group (n=33), and no significant difference was found between the two groups. These two kinds of internal fixation materials exhibited good biocompatibility, and no infection and other adverse reactions occurred. These findings indicate that both titanium alloy and stainless steel as internal fixation materials have good biocompatibility and therapeutic effects. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | Related Articles | Metrics

Select

Biomechanical properties of a decellularized scaffold of lyophilized bovine tendon Qian Chuang, Chen Xiong-sheng, Zhou Sheng-yuan, Zhu Wei 2015, 19 (30):  4865-4869.  doi: 10.3969/j.issn.2095-4344.2015.30.021 Abstract ( 297 )   PDF (1106KB) ( 300 )   Save BACKGROUND: Current decellularized methods have the certain damage to the extracellular matrix and reduce the biomechanical properties of acellular scaffolds. OBJECTIVE: To explore the biomechanical properties of decellularized scaffold of lyophilized bovine tendon. METHODS: Sixty lyophilized fiber bundles from fresh flexion tendon of calf toes were randomly divided into two groups: control group and experimental group. In the experimental group, serine protease inhibitors were placed aseptically for 24 hours at room temperature, then the samples were rinsed with PBS and transferred to the low concentration of trypsin+ethanol mixed solution to remove the cell wall without destruction of the extracellular matrix at room temperature for 5 hours; after that, the fiber bundles were cultured in DNA enzyme solution for 5 hours, finally the acellular scaffold was completed and rinsed with PBS for 48 hours and dried at room temperature in sterile room. No treatment was done in the control group. Modulus of elasticity, durability and maximum stress were determined in the two groups. RESULTS AND CONCLUSION: Similar elastic modulus and durability were found in the two groups, but the maximum stress in the experimental group was significantly lower than that in the control group (P < 0.01). These findings indicate that the lyophilized acellular tendon fibers can mimic the biological function of bovine tendon  fibers to a certain extent. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

Application of three-dimensional printing technique in manufacturing scaffolds for bone tissue engineering  Yu Qiang, Tian Jing 2015, 19 (30):  4870-4875.  doi: 10.3969/j.issn.2095-4344.2015.30.022 Abstract ( 382 )   PDF (893KB) ( 414 )   Save BACKGROUND: Three-dimensional printing technique has been applied in medical fields since it was invented in the end of 20th century. Recently it has been widely used in manufacturing scaffolds for bone tissue engineering. OBJECTIVE: To review the basic concept of the scaffold for bone tissue engineering, the basic requirements for three-dimensional printing technique in scaffold engineering, different materials used in bone tissue engineering, the advantages and limitations of three-dimensional printing technique and the outlook of three-dimensional printing technique applied in manufacturing scaffold for bone tissue engineering. METHODS: The first author did a computer-aided retrieval of the MEDLINE database, Science Direct database, CNKI database, and CQVIP database for articles relevant to three-dimensional printing technique used in manufacturing scaffolds for bone tissue engineering published between January 1990 and February 2015. The key words were “three-dimensional printing, tissue engineering, rapid prototyping technology, scaffold, materials” in English and Chinese, respectively. Repetitive studies were excluded, and 33 of 52 related literatures were adopted in result analysis. RESULTS AND CONCLUSION: Three-dimensional printing technique has many advantages such as high resolution, high velocity and the freedom to build unlimited geometries. There are some requirements for the powder and binder used to construct bone tissue engineering scaffolds using the three-dimensional printing technique, such as the flowability, stability and wettability. A wide range of materials can be used: synthetic and natural polymers, ceramics, as well as composites of the aforementioned. Various kinds of powder take responsibility of different features of scaffolds, resulting from the advantages and disadvantages of different materials. Although this technique has some limitations such as high cost and the difficulty of commercial production, its application still has a bright future. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

Different materials for rotator cuff repair augmentation: intensity, degradation rate and acidity degradation products Ren Shi-you, Jiang Chang-qing, Zhang Wen-tao 2015, 19 (30):  4876-4881.  doi: 10.3969/j.issn.2095-4344.2015.30.023 Abstract ( 409 )   PDF (785KB) ( 307 )   Save BACKGROUND: It is unclear what kind of material for rotator cuff repair augmentation is the safest or most effective. OBJECTIVE: To review the basic research, clinical application and prospects of materials for rotator cuff repair augmentation. METHODS: Eligible studies were identified from electronic databases including EMbase, Medline, PubMed, OVID, Cochrane Library, Springerlink, CNKI, WanFang, and VIP. RESULTS AND CONCLUSION: There are four kinds of patches used for rotator cuff augmentation: tendon patches, non-degradable patches, extracellular matrix-based patches and degradable synthetic patches。 Tendon patches have good mechanical strength, but postoperative foreign body reactions and increasing risk of infection and unable to recover the normal structure are problems to be solved. Non-degradable patches also have good mechanical strength, but the long-term safety is unclear. Extracellular matrix-based patches remain a lower mechanical strength and have a higher failure rate. Degradable synthetic patches are proposed to overcome these previous issues by combining well-adjusted mechanical properties with biological additives and minimize risk of infection by completely absorbing in a time-dependent manner. However, migration of bioactive cells, regulation of degradation rate and suppression of acidic degradation products is are existing problems to be solved. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

Enhanced real-time catheter localization using ultrasonic technique Chen Jing-ling, Lian Rui, Zhang Guo-qiang, Gong Yan, Chen Xiao-nong 2015, 19 (30):  4882-4885.  doi: 10.3969/j.issn.2095-4344.2015.30.024 Abstract ( 293 )   PDF (534KB) ( 282 )   Save BACKGROUND: To ensure the catheter position is very important for interventional catheters. In emergency, rapid and accurate catheter insertion is required. Ultrasound can real-time track the movement of catheters in vivo. It is safe to patient, which has exhibited a bright future in catheter placement. OBJECTIVE: To compare the current methods for improving ultrasonic localization methods and to prospect the future development and improvement of real-time ultrasonic localization of catheters in vivo. METHODS: Literature search was carried out based on PubMed (1990-01/2015-04) and Espacenet with the key words of “catheter, ultrasonic guidance, ultrasound localization, enhanced localization” for the initial retrieval of relevant articles. RESULTS AND CONCLUSION: To improve the image quality and increase the accuracy of catheter placement by ultrasound, recent efforts have been focused on two paths. One is to improve the resolution of ultrasonic images by enhancing ultrasound equipment or ultrasonic guidance system. The other is to modify catheter itself to obtain high acoustic impedance differential and improve its echogenicity. The latter approach can be potentially applied in all kinds of catheters and is more economical and practical. Therefore, in future researches, innovation and design of catheter materials for catheter fabricating will play an important role in promoting the real-time ultrasonic localization of catheters. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

Brace materials for patients with post-stroke hemiplegia: categories and biocompatibility Xin Yu-fu, Rong Shan-shan, You Ai-min, Hu Yan-feng 2015, 19 (30):  4887-4891.  doi: 10.3969/j.issn.2095-4344.2015.30.025 Abstract ( 637 )   PDF (898KB) ( 419 )   Save BACKGROUND: Rehabilitation brace can significantly improve the motor function of patients with post-stroke hemiplegia. OBJECTIVE: To investigate the types and biocompatibility of brace materials for post-stroke hemiplegia. METHODS: A computer-based search of Wanfang, CNKI, PubMed databases was performed for articles related to post-stroke hemiplegia and biocompatibility of brace materials published from 1999 to 2015 using the keywords of “cerebral apoplexy, hemiplegia, support, material” in Chinese and English, respectively. In the same field, the articles published recently or in authoritative journals were preferred. Finally, 15 articles were enrolled in result analysis. RESULTS AND CONCLUSION: Thermoplastic orthoses are mainly made of polypropylene materials, which are used for foot drop caused by post-stroke hemiplegia. Polypropylene has high strength and good toughness, and it is also safe and non-toxic. Semi-rigid planta pedis can help the lift of the toe in swing phase. Orthoses made of polymer fiber materials are characterized by ease of use, good toughness, high strength, and good air permeability, which cannot impact X-ray examination. Carbon fiber materials have light mass, high specific strength and modulus, good anti-fatigue performance, good safety performance and good designability. Clinical trials have shown that patients wearing ankle foot orthoses made of polypropylene and carbon fiber materials have improvement in walking distance and speed of climbing stairs, and these patients also feel more balanced and secure. Experimental studies on different orthotics materials can get more patient preferences, which have a great help for the design and development of orthotics materials. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

Percutaneous verterbroplasty with bone cement injection for osteoporotic vertebral compression fractures via transpedicular approach Cai Jia, Hao Ying-wei, Li Chao, Yang Hua-qun 2015, 19 (30):  4892-4897.  doi: 10.3969/j.issn.2095-4344.2015.30.026 Abstract ( 287 )   PDF (1242KB) ( 243 )   Save BACKGROUND: Studies have shown that percutaneous vertebroplasty is a better method to repair osteoporotic vertebral compression fractures, but there are still less specific schemes of transpedicular approach. Whether unipedicular or bipedicular approach is preferred is still controversial. OBJECTIVE: To compare the clinical efficacy of percutaneous verterbroplasty via unipedicular and bipedicular approach on osteoporotic vertebral compression fractures. METHODS: Totally 118 patients with osteoporotic vertebral compression fractures who had been admitted at the Department of Orthopedics, the First People’s Hospital of Kashi from June 2010 to June 2013 and followed up over 1 year were enrolled and randomly divided into unipedicular and bipedicular groups, with 59 in each group.  These two groups were compared in terms of bone cement volume, bone cement leakage, kyphosis correction, vertebral height restoration, visual analog scale score, Oswestry disability index, activity of daily living scale score, SF-36 score, and postoperative complications. RESULTS AND CONCLUSION: The cement leakage rate was lower in the unipedicular group (34%) than the bipedicular group (37.3%), but there was no significant difference (P=0.701 > 0.05). The kyphosis correction and scoliosis correction had no statistical significance between the two groups (P > 0.05). The mean vertebral height was improved significantly in both two groups at 1 year after operation (P < 0.05), but there was no difference between the two groups before and after operation (P > 0.05). There were also no significant differences between the two groups in terms of visual analog scale score, Oswestry disability index, activity of daily living scale score, SF-36 score before and after operation, but these indexes were all improved significantly in each group at 1 year after operation than before operation (P < 0.05). The bone cement amount of the unipedicular group was lower than that of the bipedicular group (P=0.001 < 0.05), and the operation time was also shorter in the unipedicular group than the bipedicular group (P=0.000 < 0.05). No serious complications occurred in the two groups. These findings indicate that percutaneous verterbroplasty via unipedicular and bipedicular approach has good analgesic and repair outcomes in patients with osteoporotic vertebral compression fractures, and the unipedicular approach is better than the bipedicular approach in the following aspects: less bone cement volume, lower cement leakage and shorter operation time. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

Implantation of porous titanium alloy rods for the treatment of early-stage  osteonecrosis of the talus Diao Xiao-ming 2015, 19 (30):  4898-4902.  doi: 10.3969/j.issn.2095-4344.2015.30.027 Abstract ( 466 )   PDF (826KB) ( 431 )   Save BACKGROUND: Latest researches outside China have shown that compared with conventional core decompression therapy, porous titanium alloy rod implantation for the treatment of talus fracture has better therapeutic effects and more greatly reduces the difficulties of operation.  OBJECTIVE: To compare the clinical effects of porous titanium alloy rod implantation and core decompression therapy for the treatment of early-stage osteonecrosis of the talus. METHODS: Sixty patients with early-stage osteonecrosis of the talus, 33 males and 27 females, aged from 18 to 73 years, were included in the experiment. The patients were randomly and evenly divided into experimental group and control group. The patients in the experimental group received porous titanium alloy rod implantation, while the patients in the control group were subjected to conventional core decompression therapy. The progression of necrotic area after 12 months of treatment, infection rate and ankle swelling within 24 weeks after treatment and lameness incidence within 12 months of treatment were compared between the experimental and control groups. RESULTS AND CONCLUSION: At 12 months after treatment, the progression of osteonecrosis of the talus in the experimental group was significantly slower than that in the control group (P < 0.05). The infection rate and ankle swelling rate immediately and 2, 4, 12 and 24 weeks after treatment in the experimental group were significantly lower than those in the control group (P < 0.05). At 1, 3, 6 and 12 months after treatment, the lameness incidence of patients in the experimental group was significantly lower than that in the control group (P < 0.05). There were no adverse reactions associated with the implant materials in the experimental group. These results demonstrate that porous titanium alloy rod implantation contributes to bone tissue regeneration and promotes ankle function restoration in patients with early-stage osteonecrosis of the talus.  中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 References | Related Articles | Metrics

Select

Titanium mesh combined with forearm free flap for maxillary defects is better to maintain swallowing and language function Liu Zhong 2015, 19 (30):  4903-4907.  doi: 10.3969/j.issn.2095-4344.2015.30.028 Abstract ( 379 )   PDF (858KB) ( 401 )   Save BACKGROUND: Prosthetic appliance is often adopted for clinical maxillary repair, which can maintain swallowing and language function in patients with a certain extent, but if the defect is too large, the prosthesis has a poor fixed effect that is prone to inducing various adverse consequences. OBJECTIVE: To explore the maintenance effect of titanium mesh combined with forearm free flap on swallowing and language function in patients with maxillary defects. METHODS: A total of 35 patients with maxillary defects, 19 males and 16 females, aged 33-93 years, were enrolled. Among them, 17 patients underwent maxillectomy and wound packing with iodoform gauzes, and then after 1 year, these patients were given prosthesis repair as control group; another 18 patients were subjected to titanium mesh combined with forearm free flap for repair of maxillary defects as observation group. All the patients were followed up for 24 months, and the swallowing and language functions were evaluated. RESULTS AND CONCLUSION: At 24 months after repair, all the patients were satisfied with facial appearance, and there were no adverse reactions related to repair materials. Scores on swallowing function, language function, pain fucntion, face function, motor function, entertainment function, masticatory function and oral health were significantly higher in the observation group than the control group (P < 0.05), and the score on the shoulder dysfunction was lower in the observation than the control group, indicating the patients in the observation group had a higher quality of life than those in the control group. These findings indicate that titanium mesh combine with forearm free flap for maxillary defect repair can be better to maintain the swallowing and language function of patients. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

Autologous peroneus brevis and allogeneic tendon to reconstruct lateral collateral ligament of the ankle joint Wang Cheng-wei, Guo Peng-chao, Wang Xue, Paerhati, Li Lu-bing, Bai Jing-ping 2015, 19 (30):  4908-4914.  doi: 10.3969/j.issn.2095-4344.2015.30.029 Abstract ( 381 )   PDF (1111KB) ( 296 )   Save BACKGROUND: Autologous peroneus brevis and allogeneic tendon are often used for reconstruction of lateral collateral ligament of the ankle joint, but these two kinds of materials have different histological and biomechanical properties. OBJECTIVE: To compare the clinical effects of autologous peroneus brevis and allogeneic tendon to reconstruct lateral collateral ligament of the ankle joint. METHODS: Sixty-six patients with chronic external ankle instability caused by old injury to lateral collateral ligament of the ankle joint were enrolled, aged 15-63 years. The 34 of 66 patients underwent lateral ligament reconstruction using autologous peroneus brevis and the rest 32 patients received lateral ligament reconstruction using allogeneic tendon. After reconstruction, reaction time of the peroneous brevis, talar tilt angle and anterior talar translation, visual analog scale score and the American Orthopaedic Foot and Ankle Society (AOFAS) score were compared between the two groups. RESULTS AND CONCLUSION: At the last follow-up, the visual analog scale score, tilt angle and anterior talar translation were lowered in the two groups compared with the previous (P < 0.05), and the AOFAS scores were increased significantly in the two groups (P < 0.05); the reaction time of the peroneous brevis was increased in  the autologous peroneus brevis group (P < 0.05) and decreased in the allogeneic tendon group (P < 0.05); the above-mentioned indexes had no difference between the two groups. These findings indicate that autologous peroneus brevis and allogeneic tendon have similar effects on the lateral ligament reconstruction in terms of postoperative ankle function, stability and activity levels, but the allogeneic tendon shows advantages on less trauma and shorter operation time. 中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics

Select

Autologous skin grafting, vacuum sealing drainage and external fixation for repair of complex and severe open fracture of the elbow joint Wang Tao, Zhang Tao, Feng Shi-qing, Guo Hong-gang, Zheng Yong-fa 2015, 19 (30):  4915-4920.  doi: 10.3969/j.issn.2095-4344.2015.30.030 Abstract ( 240 )   PDF (1658KB) ( 277 )   Save BACKGROUND: The incidence of open fracture of the elbow joint is increased rapidly with an increased number of accidents. Fractures are often accompanied by severe soft tissue injuries. At present, a combined therapy of autologous skin grafting, vacuum sealing drainage and external fixation for the treatment of open fractures has been widely reported. OBJECTIVE: To investigate the characteristics of the combined therapy of autologous skin grafting, vacuum sealing drainage, and external fixation for repair of complex and severe open fracture of the elbow joint. METHODS: A total of 41 patients with complex and severe open fracture of the elbow joint who received the combined therapy of autologous skin grafting, vacuum sealing drainage and external fixation during January 2009 to December 2013 in General Hospital of Tianjin Medical University, China were selected. All patients were treated with routine debridement, external fixation and vacuum sealing drainage to cover wound during the first period. During the second period, autologous skin grafting or flap transfer was used to repair wound when the fresh granulation tissue covered the wound. RESULTS AND CONCLUSION: The postoperative follow-up period of these 41 patients was 8-22 months, with an average period of 13 months. External fixation period was 8-13 months with an average period of 9.8 months. The open wounds were completely healed after autologous skin grafting or skin flaps transfer. Fractures  were healed in 31 patients during the first period. There were 7 cases of delayed union, 3 cases of nonunion. All fractures were completely healed during 8-12 months after iliac bone grafting. The excellent and good rate of limb function recovery was 73.1% among 41 patients with severe open fracture of the elbow joint. The limb function of Gustilo II patients better recovered. These results suggest that the clinical effect of the combined therapy of autologous skin grafting, vacuum sealing drainage and external fixation for the treatment of complex and severe open fractures of the elbow joint is satisfactory.  中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程 Figures and Tables | References | Related Articles | Metrics