Chinese Journal of Tissue Engineering Research ›› 2015, Vol. 19 ›› Issue (30): 4898-4902.doi: 10.3969/j.issn.2095-4344.2015.30.027

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Implantation of porous titanium alloy rods for the treatment of early-stage  osteonecrosis of the talus

Diao Xiao-ming   

  1. First Department of Surgery, Linyi Luozhuang Central Hospital, Linyi 276017, Shandong Province, China
  • Online:2015-07-16 Published:2015-07-16
  • About author:Diao Xiao-ming, Attending physician, First Department of Surgery, Linyi Luozhuang Central Hospital, Linyi 276017, Shandong Province, China

Abstract:

BACKGROUND: Latest researches outside China have shown that compared with conventional core decompression therapy, porous titanium alloy rod implantation for the treatment of talus fracture has better therapeutic effects and more greatly reduces the difficulties of operation. 
OBJECTIVE: To compare the clinical effects of porous titanium alloy rod implantation and core decompression therapy for the treatment of early-stage osteonecrosis of the talus.
METHODS: Sixty patients with early-stage osteonecrosis of the talus, 33 males and 27 females, aged from 18 to 73 years, were included in the experiment. The patients were randomly and evenly divided into experimental group and control group. The patients in the experimental group received porous titanium alloy rod implantation, while the patients in the control group were subjected to conventional core decompression therapy. The progression of necrotic area after 12 months of treatment, infection rate and ankle swelling within 24 weeks after treatment and lameness incidence within 12 months of treatment were compared between the experimental and control groups.
RESULTS AND CONCLUSION: At 12 months after treatment, the progression of osteonecrosis of the talus in the experimental group was significantly slower than that in the control group (P < 0.05). The infection rate and ankle swelling rate immediately and 2, 4, 12 and 24 weeks after treatment in the experimental group were significantly lower than those in the control group (P < 0.05). At 1, 3, 6 and 12 months after treatment, the lameness incidence of patients in the experimental group was significantly lower than that in the control group (P < 0.05). There were no adverse reactions associated with the implant materials in the experimental group. These results demonstrate that porous titanium alloy rod implantation contributes to bone tissue regeneration and promotes ankle function restoration in patients with early-stage osteonecrosis of the talus. 

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程

Key words: Decompression, Surgical, Talus, Ankle Joint

CLC Number: