Chinese Journal of Tissue Engineering Research ›› 2015, Vol. 19 ›› Issue (30): 4769-4773.doi: 10.3969/j.issn.2095-4344.2015.30.003

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In vivo osteogenic capability of nano-hydroxyapatite/polyamide composite material

Xu Xian-chun1, Wang Zhi2, Hou Tie-qi3   

  1. 1First Department of Orthopedics, First People’s Hospital of Yibin, Yibin 644000, Sichuan Province, China; 2Department of Bone and Joint Surgery, Affiliated Hospital of Sichuan Medical University, Luzhou 646000, Sichuan Province, China; Medical School of Jinan University, Guangzhou 510632, Guangdong Province, China
  • Online:2015-07-16 Published:2015-07-16
  • About author:Xu Xian-chun, Master, First Department of Orthopedics, First People’s Hospital of Yibin, Yibin 644000, Sichuan Province, China

Abstract:

BACKGROUND: As a bone reconstruction material, nano-hydroxyapatite has good biocompatibility and osteoconduction, but the clinical use of nano-hydroxyapatite alone still has many deficiencies.

OBJECTIVE: To explore the in vivo osteogenic capability of nano-hydroxyapatite/ polyamide composites.

METHODS: Twenty-four New Zealand white rabbits were subjected to humeral head replacement using nano-hydroxyapatite/polyamide composite material. X-ray observation and histological observation were done at 3, 6, 12, 24 weeks after replacement.

RESULTS AND CONCLUSION: (1) X-ray observation: No thinned cortical bone and ectopic ossification occurred on the upper end of the composite material at different time, and the nano-hydroxyapatite/polyamide material had no signs of fragmentation. The cortical bone around the composite material was fuzzy, and the bone mineral density was increased with time. (2) Histological observation: At 3 weeks after replacement, a large number of cells could be visible, including mesenchymal stem cells and mononuclear macrophages. At 6 weeks after replacement, a large amount of fibrous tissues, fibroblasts and mononuclear macrophages still existed in the boundary membrane, but chondrocytes and osteoblasts distributed less. At 12 weeks after replacement, a wide range of original trabecular bone began to form and were mostly flat that arranged regularly. At 24 weeks after replacement, the boundary membrane was full of bone cells, but the cells on the surface of trabecular bone were relatively regular and primitive cells in the bone tissue began to transform into the lamellar bone. These findings indicate that the nano-hydroxyapatite/polyamide material has good osteogenic capability

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程

Key words: Biocompatible Materials, Durapatite, Nylons

CLC Number: