Polyvinyl alcohol/hydroxyapatite composite hydrogel for the repair of articular cartilage defects: a histocompatibility study

doi:10.3969/j.issn.2095-4344.2015.30.015

Abstract

Abstract:

BACKGROUND: Hydroxyapatite and polyvinyl alcohol composite hydrogel used for the repair of cartilage defects can have good biological activity in the cartilage joints, effectively promote the growth of bone cells, and enhance the stability and biological activity of implant materials.
OBJECTIVE: To explore the histocompatibility of polyvinyl alcohol/hydroxyapatite composite hydrogel transplantation for the repair of articular cartilage defects.
METHODS: Twenty New Zealand rabbits were enrolled and randomly divided into control group (n=6) and experimental group (n=14). Unilateral knee cartilage defect models were constructed in the two groups. No treatment was done in the control group, and polyvinyl alcohol/hydroxyapatite composite hydrogel transplantation was performed in the experimental group. After 4, 8, 12 weeks, the animals were killed to collect knee joint specimens for gross observation and histological observation.
RESULTS AND CONCLUSION: The surface of articular cartilage in the control group was not recovered at 12 weeks after operation, and granulation tissues were full of cartilage defects. In the experimental group, the
polyvinyl alcohol/hydroxyapatite composite hydrogel was filled in the defects, and tightly connected with the surrounding cartilage tissues with clear boundary and no cell ingrowth at 4 weeks after operation. Until the 12th week, in the experimental group, the composite hydrogel was white and translucent with smooth surface. There was a clear boundary between the composite hydrogel and surrounding cartilage tissues, a great amount of cartilage cells proliferated in the interface that tightly bound to the surrounding tissues, and osteoid tissue grew. These findings indicate that the polyvinyl alcohol/hydroxyapatite composite hydrogel has good histocompatibility in the repair of cartilage defects of rabbit knee joints.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Durapatite, Cartilage, Articular, Histocompatibility

CLC Number:

R318

Lei Zhi-jian. Polyvinyl alcohol/hydroxyapatite composite hydrogel for the repair of articular cartilage defects: a histocompatibility study[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(30): 4832-4836.

Figures/Tables 1

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