Clinical effects of gelatin sponge infiltrated by mouse nerve growth factor in local treatment of peripheral nerve injury

doi:10.3969/j.issn.2095-4344.2015.30.014

Abstract

Abstract:

BACKGROUND: Several studies have attempted to apply mouse nerve growth factor to local lesions of peripheral nerve and found that local injection of mouse nerve growth factor can promote nerve recovery, which is superior to systematic application.

OBJECTIVE: To evaluate the clinical effects of gelatin sponge infiltrated by mouse nerve growth factor in the repair of peripheral nerve injury.

METHODS: Thirty-six patients with single peripheral nerve injury, including 16 males and 20 females, aged 18-48 years, were randomly divided into two groups: 18 patients in case group underwent debridement and neuroanastomosis, and then the injured nerve was wrapped by gelatin sponge which was infiltrated by mouse nerve growth factor and followed by plaster fixation, anti-inflammatory therapy, neurotrophy and circulation improvement therapy; the other 18 patients in control group were treated only with debridement and neuroanastomosis and other conventional therapies. At 4 weeks after treatment, electrophysiological examination was performed. In addition, sensory and motor function of the distal end of injured nerve was evaluated at 6 months after treatment.

RESULTS AND CONCLUSION: Sensory evoked potential and motor evoked potential showed that the recovery rate was 78% (n=14) and 83% (n=15) respectively in the case group, while 57% (n=10) and 66% (n=12) in the control group. There was significant difference between the two groups (P < 0.05). The total effective rate was 94.4% (n=17) in the case group and 83.3% (n=15) in the control group, which were statistically better in the case group than the control group (P < 0.05). These findings indicate that it is significantly effective to treat peripheral nerve injury by gelatin sponge infiltrated by mouse nerve growth factor that has good biocompatibility.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Nerve Growth Factor, Gelatin Sponge, Absorbable, Nerve Tissue

CLC Number:

R318

Li Li-jun, Shi Yu-bo, Zong Qiang, Zhu Fu-liang, Ni Dong-kui. Clinical effects of gelatin sponge infiltrated by mouse nerve growth factor in local treatment of peripheral nerve injury[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(30): 4827-4831.

Figures/Tables 2

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