Nano-chitosan/bone morphogenetic protein gel prevents absorption of rat’s alveolar ridge

doi:10.3969/j.issn.2095-4344.2014.39.008

Abstract

Abstract:

BACKGROUND: Absorption and atrophy of the alveolar ridge always happen after tooth extraction. There are still a lot of difficulties to be worked out to prevent the atrophy of the alveolar ridge.
OBJECTIVE: To investigate the effect of the nano-chitosan/bone morphogenetic protein hydrogel on preventing absorption of the residual alveolar ridge of the rats.
METHODS: Totally 54 Sprague-Dawley rats were divided randomly and equally into three groups. A model of residual alveolar ridge was made by extraction of the left central incisor. Nano-chitosan bone morphogenetic protein hydrogel was implanted into the rat’s alveolar fossa of the experimental group; the alveolar fossa of the control group was implanted with nano-chitosan hydrogel; the alveolar fossa of the blank group was implanted with nothing. Rat’s mandible was fully dissected after 3, 6, 9 weeks, respectively. Molybdenum target X-ray examination and pathological observation were evaluated.
RESULTS AND CONCLUSION: At weeks 3, 6, 9 postoperation, the residual alveolar ridge was absorbed to different degrees, which was milder in the experimental group than the cotrol group and blank group (P < 0.05). After 3 weeks, in the blank group, less new bone formed, but bleeding and a large amount of inflammatory cells were visible; in the control group, a few of osteoid tissues and lymphocytes were found; in the experimental group,new bone formed and a small amount of inflammatory cells were observed. After 6 weeks, new bone formed obviously in the experimental group, a little new bone formed in the control group, but less new bone formed in the blank group. After 9 weeks, a large amount of new bone formed in the experimental group with good osteogenic ability; only a few of new bone formed in the control and blank groups. Nano-chitosan/bone morphogenetic protein hydrogel can be used to prevent the absorption of the residual alveolar ridge after tooth extraction.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: bone morphogenetic proteins, chitosan, hydrogel

CLC Number:

R318

Chen Yu-yang, Sun Jing, Xie Fu-qiang, Zhang Yun, Wang Xin, Sun Jian. Nano-chitosan/bone morphogenetic protein gel prevents absorption of rat’s alveolar ridge[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(39): 6276-6281.

Figures/Tables 4

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