Chinese Journal of Tissue Engineering Research ›› 2024, Vol. 28 ›› Issue (16): 2534-2541.doi: 10.12307/2024.225
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Tang Liang1, Wang Hexia1, Wang Qingbo2, Pi Yihua2, Zhang Yan2
Received:
2022-12-19
Accepted:
2023-03-02
Online:
2024-06-08
Published:
2023-07-29
Contact:
Zhang Yan, Master, Associate professor, Guangxi University of Chinese Medicine, Nanning 530021, Guangxi Zhuang Autonomous Region, China
About author:
Tang Liang, Master, Associate professor, College of Physical Education and Arts Humanities, China University of Petroleum, Beijing 102249, China
Supported by:
CLC Number:
Tang Liang, Wang Hexia, Wang Qingbo, Pi Yihua, Zhang Yan. Aerobic exercise modulates mitochondrial quality control system to reverse cardiac pathological remodeling in aging rats[J]. Chinese Journal of Tissue Engineering Research, 2024, 28(16): 2534-2541.
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2.3 各组大鼠心脏结构与功能比较 与青年安静组比较,老年安静组大鼠左心室舒张末期直径下降(P < 0.05),左心室壁厚度增加(P < 0.05),二尖瓣E峰/A峰比值下降(P < 0.05),左心室收缩末期直径、左心室缩短分数和左心室射血分数无明显变化(P > 0.05);与青年安静组比较,老年运动组左心室舒张末期直径和左心室壁厚度增加(P < 0.05),左心室收缩末期直径、左心室缩短分数、左心室射血分数和二尖瓣E峰/A峰比值无明显变化(P > 0.05);与老年安静组比较,老年运动组大鼠左心室舒张末期直径和二尖瓣E峰/A峰比值升高(P < 0.05),左心室收缩末期直径、左心室壁厚度、左心室缩短分数和左心室射血分数无明显变化(P > 0.05),见表2。"
2.4 各组大鼠心脏病理组织学、心肌细胞凋亡和心肌线粒体超微结构观察 心脏苏木精-伊红染色显示,青年安静组大鼠心肌组织结构正常;老年安静组大鼠心肌细胞排列不规则,细胞肿胀,细胞数量减少;老年运动组大鼠心肌细胞数量增加,细胞浆和细胞核形态接近青年安静组,见图1。与青年安静组比较,老年安静组和老年运动组大鼠心肌细胞横截面积升高(P < 0.05);与老年安静组比较,老年运动组心肌细胞横截面积无明显变化(P > 0.05),见图2A。各组心肌细胞计数比较显示,与青年安静组比较,老年安静和老年运动组大鼠心肌细胞计数减少(P < 0.05);与老年安静组比较,老年运动组心肌细胞计数增加(P < 0.05),见图2B。"
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