Chinese Journal of Tissue Engineering Research ›› 2024, Vol. 28 ›› Issue (14): 2145-2151.doi: 10.12307/2024.322
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Wu Yuzhen1, Sun Qing2, Liu Xia1, Zhou Yu1, Jin Qiguan2
Received:
2023-02-11
Accepted:
2023-05-05
Online:
2024-05-18
Published:
2023-07-28
Contact:
Liu Xia, Professor, Master’s supervisor, Hunan Provincial Key Laboratory of Physical Fitness and Sports Rehabilitation, Physical Education College of Hunan Normal University, Changsha 410012, Hunan Province, China
About author:
Wu Yuzhen, Master candidate, Hunan Provincial Key Laboratory of Physical Fitness and Sports Rehabilitation, Physical Education College of Hunan Normal University, Changsha 410012, Hunan Province, China
Sun Qing, Master, Physical Education College of Yangzhou University, Yangzhou 225127, Jiangsu Province, China
Supported by:
CLC Number:
Wu Yuzhen, Sun Qing, Liu Xia, Zhou Yu, Jin Qiguan. Variation in renal function of type 2 diabetic rats undergoing aerobic exercise[J]. Chinese Journal of Tissue Engineering Research, 2024, 28(14): 2145-2151.
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2.7 大鼠肾组织中TGF-β1、Notch1、Jagged1、Hes1 mRNA表达变化 如图3所示,与正常对照组相比,糖尿病对照组大鼠肾脏中TGF-β1、Notch1、Jagged1、Hes1 mRNA表达水平均极显著增加(P < 0.01);运动后TGF-β1、Notch1及Jagged1 mRNA表达水平极显著降低(P < 0.01),Hes1 mRNA的表达降低不显著(P > 0.05),TGF-β1、Notch1、Jagged1、Hes1 mRNA表达仍显著或极显著高于正常对照组。提示糖尿病能够使大鼠肾脏TGF-β1/Notch1信号通路上调,8周的游泳运动对其有显著的抑制作用。"
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