Mesenchymal stem cell-derived exosomes carrying miRNAs in tissue repair and treatment of related diseases: application and advantages

doi:10.12307/2021.148

Abstract

Abstract: BACKGROUND: In recent years, increasing evidences indicate that exosomes secreted by mesenchymal stem cells (MSC-Exo) exert a repair effect on tissue and organ damage and can be used for the treatment of various diseases. MicroRNA (miRNA) is one of the most studied components in MSC-Exo. Gene editing of MSC-Exo carrying miRNA through genetic engineering and other technologies can make it a promising acellular preparation in the field of tissue engineering.
OBJECTIVE: To review the research progress of MSC-Exo carrying miRNA in the field of tissue engineering.
METHODS: The PubMed, Web of Science and CNKI databases were used to search by the first author for original and review articles published from January 2000 to May 2020 using the key words of “mesenchymal stem cells; exosome; micro RNA” in English and Chinese respectively. Totally 38 articles were included in analysis.
RESULTS AND CONCLUSION: In various systems, MSC-Exo has been shown to promote cell proliferation, inhibit apoptosis and promote angiogenesis through their miRNAs. Many preclinical studies have been carried out on the therapeutic effects of MSC-Exo and its miRNAs in cardiovascular system, digestive system, nervous system, endocrine system and immune system diseases, revealing that miRNAs exist in MSC-Exo, and their regulating role in repairing tissue damage, preventing and treating related diseases.

Key words: mesenchymal stem cells, exosome, microRNA, repair, tissue engineering, review

CLC Number:

Shi Qin, Sun Baolan, Yang Xiaoqing, Zhang Yuquan . Mesenchymal stem cell-derived exosomes carrying miRNAs in tissue repair and treatment of related diseases: application and advantages[J]. Chinese Journal of Tissue Engineering Research, 2021, 25(31): 5040-5045.

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