Chinese Journal of Tissue Engineering Research ›› 2021, Vol. 25 ›› Issue (7): 1129-1134.doi: 10.3969/j.issn.2095-4344.2181

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Effects of Chinese medicine on proliferation, differentiation and aging of bone marrow mesenchymal stem cells regulating ischemia-hypoxia microenvironment

Wang Shiqi1, Zhang Jinsheng2   

  1. 1Henan University of Chinese Medicine, Zhengzhou 450046, Henan Province, China; 2Third Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450046, Henan Province, China
  • Received:2020-01-02 Revised:2020-04-09 Accepted:2020-05-20 Online:2021-03-08 Published:2020-12-09
  • Contact: Zhang Jinsheng, MD, Professor, Chief physician, Doctoral supervisor, Third Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450046, Henan Province, China
  • About author:Wang Shiqi, Doctoral candidate, Henan University of Chinese Medicine, Zhengzhou 450046, Henan Province, China
  • Supported by:
    the National Natural Science Foundation of China (General Program), No. 81673893

Abstract: BACKGROUND: Traditional Chinese medicine has certain value and significance in the treatment of ischemic cardiovascular and cerebrovascular diseases by regulating the ischemia-hypoxia microenvironment and improving the survival rate and differentiation rate of stem cells. 
OBJECTIVE: To sort out and analyze the research progress of traditional Chinese medicine on regulating ischemia-hypoxia microenvironment intervention on proliferation, differentiation, aging and autophagy of bone marrow mesenchymal stem cells in recent years.
METHODS: The full-text database of Chinese journals, PubMed and Wanfang were retrieved with the keywords of “bone mesenchymal stem cells, ischemia-hypoxia microenvironment, proliferation, differentiation, aging” in English or “bone marrow mesenchymal stem cells, ischemia and hypoxia, proliferation, differentiation, aging” in Chinese for articles regarding effects of ischemia and hypoxia microenvironment on survival rate and differentiation rate of bone marrow mesenchymal stem cells published from 2002 to 2019. Fifty-five articles were selected for review, including 22 Chinese articles and 33 English articles.
RESULTS AND CONCLUSION: The ischemia-hypoxia microenvironment is the important reason for the low survival rate and differentiation rate of bone marrow mesenchymal stem cells. There are many adverse reactions in the intervention of bone marrow mesenchymal stem cells with gene modification or cell molecules and drugs, which have become difficult problems to be solved in modern medicine. Exploring the internal relationship between microenvironment and stem cells using single or active components of traditional Chinese medicine combined with RNA transcriptomics is a new way to improve the viability of stem cells. 

Key words: stem cells, bone marrow mesenchymal stem cells, ischemia-hypoxia, microenvironment, proliferation and differentiation, aging, Chinese medicine, review

CLC Number: