Hydrodynamic model of carotid artery atherosclerosis: hemodynamic changes of carotid atherosclerotic plaques under cervical rotatory manipulation

doi:10.3969/j.issn.2095-4344.1174

Abstract

Abstract:

BACKGROUND: Cervical rotation manipulation is a non-surgical method of cervical spondylosis, showing significant treatment efficacy. But the safety for patients with carotid artery atherosclerosis remains obscure.
OBJECTIVE: To analyze the hemodynamic changes of atherosclerotic carotid arteries treated by cervical rotatory manipulation, and to explore the effect of cervical rotatory manipulation on the hemodynamics of atherosclerotic plaque.
METHODS: Eight cases of stenosis of ramification of the carotid artery with plaque on MRI. The hemodynamic model of carotid artery atherosclerosis was established, assigned with general boundary conditions and simulated the cervical stretch during cervical rotatory manipulation. All models were grouped and stretched into 0% (control group), 7% and 16% stretch to simulate the hemodynamic changes of atherosclerotic plaque. The hemodynamic parameters, including average wall shear stress, the maximum wall shear stress, the average maximum wall shear stress, the blood velocity of the plaque, and blood flow vectorgraph were compared among groups.
RESULTS AND CONCLUSION: (1) All hemodynamic parameters had no significant differences between 7% stretch and control groups (P > 0.05). Compared with the control group, the wall shear stress, the maximum wall shear stress, and the maximum wall shear stress in the 16% stretch group were significantly increased (P < 0.05), and other indexes showed no significant differences. (2) In summary, different stretches by cervical rotatory manipulation possess different effects on plaque, and a 16% stretch may affect the hemodynamics of plaque.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Carotid Arteries, Atherosclerosis, Hemodynamics, Tissue Engineering

CLC Number:

R445

Chen Yili, Lao Yonghua, Zhang Shaoqun, Wu Baofeng, Li Yikai . Hydrodynamic model of carotid artery atherosclerosis: hemodynamic changes of carotid atherosclerotic plaques under cervical rotatory manipulation[J]. Chinese Journal of Tissue Engineering Research, 2019, 23(15): 2403-2408.

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