Therapeutic efficacy of moxibustion at different distances on type II collagen-induced arthritis

doi:10.3969/j.issn.2095-4344.2017.08.016

Abstract

Abstract:

BACKGROUND: Moxibustion can improve the symptoms of rheumatoid arthritis and reduce inflammation, but there are no uniform operation standards. The moxibustion distance becomes one of factor influencing the therapeutic efficacy.
OBJECTIVE: To compare the effects of different moxibustion distances on rheumatoid arthritis, and to explore the optimal distance.
METHODS: The 8 of 40 male Sprague-Dawley rats were randomly selected as controls. The other 32 were used to make animal modes of collagen type II-induced ankle arthritis, and then given moxibustion at Shenshu (BL23) and Zusanli (ST36) at an interval of 1, 2 and 3 cm, respectively, once daily, 10 minutes at each point, 6 days per course for three courses, with a course interval of 1 day. Model rats with no treatment acted as model group.
RESULTS AND CONCLUSION: Compared with the control group, the toe volume, arthritis index and serum levels of interleukin-1β and tumor necrosis factor-α except the body mass were significantly increased in the model group (P < 0.01). After moxibustion treatment, these indexes were significantly decreased in the three treatment groups (P < 0.01), especially in the 1 and 2 cm groups (P < 0.01). Narrowed articular cavity, intra-articular inflammation and pannus formation were observed in the model group, while only moderate inflammatory cell infiltration and few pannus formation were found in the 1, 2, 3 cm groups. These results indicate that moxibustion improves joint functions and regulates immune reaction by downregulating the levels of interleukin-1β and tumor necrosis factor-α, as well as reducing synovial hyperplasia. In addition, the optimal distance for moxibustion is 1 or 2 cm, which is a momentous proposition to improve therapeutic efficacy.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Tissue Engineering, Arthritis, Experimental, Arthritis, Rheumatoid, Rats

CLC Number:

R318

Wang Yang, Wu Xin-yu, Sun Zhi-ling, Zhang Yong-yi, Xue Lian, Qin Xue. Therapeutic efficacy of moxibustion at different distances on type II collagen-induced arthritis[J]. Chinese Journal of Tissue Engineering Research, 2017, 21(8): 1241-1245.

Figures/Tables 3

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