Biocompatibility of intraocular lens via oxygen plasma treatment

doi:10.3969/j.issn.2095-4344.2013.21.016

Abstract

Abstract:

BACKGROUND: Oxygen plasma treatment can greatly improve the hydrophilicity and biocompatibility of bicomponent room temperature vulcanized polydimethylsiloxane intraocular lens. However, plasma-aggravated thin film may curl, rupture or dissect due to binding with matrix noncovalent bond, thus affecting the physicochemical properties and optical performance of the material.
OBJECTIVE: To evaluate the in vitro biocompatibility of bicomponent room temperature vulcanized polydimethylsiloxane intraocular lens materials after oxygen plasma processing.
METHODS: Oxygen plasma treatment was employed to optimize the surface of intraocular lens materials using the surface modification technique. The power and duration were 20 W, 50 W, 100 W, and 30 seconds, 1 minute, 10 minutes, respectively. Water contact angle, fourier transform infrared spectroscopy-attenuated total reflection, X-ray photo electron spectroscopy analysis were adopted to analyze the hydrophilicity and the surface chemical composition of the material. Scanning electron microscopy and atomic force microscope were used to observe the surface morphology. Cellular adhesion was performed by seeding human lens epithelial cells onto the surface of the materials to evaluate the effect of surface modification on its biocompatibility.
RESULTS AND CONCLUSION: The surface modification of intraocular lens materials by oxygen plasma treatment under optimal conditions (100 W, 30 seconds, 20 mL/min, 40 Pa) could improve the surface hydrophilicity and biocompatibility of the material without etching effect.

Key words: biomaterials, material biocompatibility, bicomponent room temperature vulcanized polydimethylsiloxane, intraocular lens, oxygen plasma treatment, surface modification, biocompatibility, lens epithelial cells, hydrophilicity, provincial grants-supported paper

CLC Number:

R318

Xia Rui-jing, Xu Xu, Luo Li, Li Ling-li, Chen Hao. Biocompatibility of intraocular lens via oxygen plasma treatment[J]. Chinese Journal of Tissue Engineering Research, doi: 10.3969/j.issn.2095-4344.2013.21.016.

Figures/Tables 4

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