Abstract:

BACKGROUND: In clinic, bone grafting can be adopted to treat alveolar bone defect, and the selected bone graft materials will have a certain impact on the ultimate effect of bone grafting.
OBJECTIVE: To explore the feasibility and reliability of osteoinduction active materials in the repair of alveolar cleft defects.
METHODS: A total of 63 patients with alveolar cleft defect, including 33 male and 30 female patients, aged 8 to 15 years, were enrolled and treated by bone grafting. Patients were divided into autologous bone group (n=32) and osteoinduction active material group (n=31) according to different bone graft materials. During 12 months of follow-up after the treatment, the bone grafting effect, bone density, canine condition and adverse reactions were observed.
RESULTS AND CONCLUSION: There was no significant difference in the total effective rate between the autologous bone and osteoinduction active material groups (P > 0.05). Among the seven unerupted canines in the autologous bone group, two teeth erupted, four moved to the bone grafting area, and one appeared to have no obvious changes. Among the six unerupted canines in the osteoinduction active material group, two teeth erupted, two appeared to have no changes, and two moved to graft bone area. The bone density in these two groups was significantly increased after tooth restoration (P < 0.05). There was no significant difference in the bone density between these two groups after repair. Infection, rejection, bone graft loss and other adverse
events did not occur in these two groups. These results demonstrate that the osteoinduction active materials in the treatment of alveolar cleft defects can achieve similar outcomes with the autologous bone graft, which has a certain clinical feasibility and reliability.
中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Bone Transplantation, Alveolar Process, Bone Density, Tissue Engineering