Chinese Journal of Tissue Engineering Research ›› 2017, Vol. 21 ›› Issue (25): 4075-4081.doi: 10.3969/j.issn.2095-4344.2017.25.023

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Application of human acelluar amniotic membrane in tissue engineered scaffold construction

Yang Ji-bin, Xiong Hua-zhang, Li Yu-wan, Liu Yi   

  1. The First Department of Orthopedics, the Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, Chin
  • Revised:2017-07-03 Online:2017-09-08 Published:2017-10-09
  • Contact: Liu Yi, Professor, Master’s supervisor, the First Department of Orthopedics, the Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China
  • About author:Yang Ji-bin, Studying for master’s degree, the First Department of Orthopedics, the Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China
  • Supported by:

    the Science & Technology Program of Guizhou Province, No. SY[2010]3091; the Science & Technology Program of Guizhou Province, No. LH[2016]7477

Abstract:

BACKGROUND: Human acellular amniotic membrane is a kind of extracellular matrix material with good biocompatibility and biological activity. It has been widely used in various clinical studies because of its low immunogenicity, small rejection and easy preparation.
OBJECTIVE: To review the applications of human acellular amniotic membranes in tissue engineering field, such as skin, blood vessel, cornea, cartilage and bone.
METHODS: CNKI (from January 2005 to May 2017), CBMdisc (from January 2005 to May 2017), PubMed (from January 1990 to May 2017) and Elsevier (from January 1990 to May 2017) were retrieved for articles addressing the application of human acellular amniotic membrane as a tissue-engineered scaffold in the bone, cartilage, skin, and blood vessels. The keywords were “acelluar amniotic membrane, scaffold, material, tissue engineering ECM" in Chinese and English, respectively.
RESULTS AND CONCLUSION: Human acellular amniotic membrane owns the structure and function of the natural extracellular matrix, which can be combined with stem cells from different sources to differentiate into different tissues and organs, such as bone, cartilage, skin, blood vessel, and corneal tissues. As a tissue-engineered scaffold, human acellular amniotic membrane has good biocompatibility, biodegradability and low immunogenicity, although it has some shortcomings, such as poor strength and post-transplantation rejection reactions. Therefore, the future studies are mainly focused on shortening the adhesion time between cells and scaffolds, increasing the own mechanical strength of human acellular amniotic membrane, optimizing the cell growth microenvironment, and combining human acellular amniotic membrane with other tissue-engineered scaffolds. 

中国组织工程研究杂志出版内容重点:干细胞;骨髓干细胞;造血干细胞;脂肪干细胞;肿瘤干细胞;胚胎干细胞;脐带脐血干细胞;干细胞诱导;干细胞分化;组织工程

Key words: Amnion, Excellular Matrix, Tissue Engineering

CLC Number: