Effect of nanosilver and nanohydroxyapatite mixed filling on osseointegration of immediate implants

doi:10.3969/j.issn.2095-4344.2015.47.019

Abstract

Abstract:

BACKGROUND: Nanosilver has significant antibacterial properties, and nanohydroxyapatite has good biological activity and mechanical strength, while their mixture cannot only promote bone formation but also have antibacterial properties.
OBJECTIVE: To observe the effect of nanosilver and nanohydroxyapatite mixed filling on the osseointegration of immediate implants.
METHODS: Nine New Zealand white rabbits were randomly divided into experimental group (n=6) and control group (n=3) after four incisors from the upper and lower jaw were extracted. The mixture of nanosilver and nanohydroxyapatite was filled into the tooth socket in the experimental group, while nanohydroxyapatite was filled into the tooth socket in the control group. Titanium screw was immediately implanted into both groups. The intact maxilla and mandibular specimens were harvested at the 4th, 8th, and 12th weeks after operation. Gross observation, X-ray bone density analysis, torque test and histological observation were conducted.
RESULTS AND CONCLUSION: The gray value and maximum torque value of regenerated osseous tissue at different time points in experimental group were significantly higher than those in the control group (P < 0.05). Within 12 weeks of implantation, the bone formation rate and maturity of new bone tissue were higher in the experimental group compared with the control group, and no inflammatory cell infiltration occurred. At the 4th week after implantation, there was a large amount of inflammatory cell infiltration, and few inflammatory existed at the 8th week after implantation. These results demonstrate that compared with nanohydroxyapatite alone, the mixture of nanosilver and nanohydroxyapatite shows better antibacterial effect, biocompatibility and osteoinductive ability, which may accelerate osseointegration and promote osteogenesis.
中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Durapatite, Nanostructures, Osseointegration, Tissue Engineering

Zheng Yu, Li Bing-ting, Wang Li-jie, Fan Shi-feng, Hou Xiao-wei. Effect of nanosilver and nanohydroxyapatite mixed filling on osseointegration of immediate implants[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(47): 7649-7654.

Figures/Tables 4

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