Circulating fibrocytes and chronic wound healing

doi:10.3969/j.issn.2095-4344.2015.24.024

Abstract

Abstract:

BACKGROUND: Circulating fibrocytes originated from the peripheral blood are a fibroblast-like cell subpopulation of leukocytes. Circulating fibrocytes play an essential role in wound repair by secreting extracellular matrix proteins and cytokines, initiating antigen-specific immunity, accelerating wound contraction as well as promoting angiogenesis. However, the potential role for improving chronic wound healing and its mechanism is still unclear.
OBJECTIVE: To summarize the biological features of circulating fibrocytes and its potential role and mechanism in accelerating chronic wound healing.
METHODS: A computer-based search of CNKI database from 2000 to 2014, PubMed database from 1994 to 2014 and Foreign Medical Journal Full-Text Service database from 2000 to 2014 was performed using “circulating fibrocytes, non-healing wounds, diabetic foot ulcer, wound healing, cell therapy” in Chinese and English as the keywords to retrieve articles related to circulating fibrocytes, refractory mechanism of chronic wound healing and cell therapy for chronic wounds. Totally 54 articles meeting the inclusive criteria were included in result analysis.
RESULTS AND CONCLUSION: Cell therapy with circulating fibrocytes is a safe and effective treatment for improving wound healing and has been used to repair various chronic wounds in the recent decades. Circulating fibrocytes are a distinct subpopulation of fibroblast-like leukocytes in the peripheral blood. It is able to migrate into wound sites at the early stage of wound repair and plays an active role in the wound healing process by secreting extracellular matrix proteins, cytokines, presenting antigens, contracting wound and promoting neovascularization. Recently, it has been proved in animal experiments that circulating fibrocytes can accelerate chronic wound healing, especially diabetic chronic wound.

中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程

Key words: Wound Healing, Diabetic Foot, Tissue Therapy

CLC Number:

R318

Bao Ji-hong, Yang Jing, Chen Bin. Circulating fibrocytes and chronic wound healing[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(24): 3899-3904.

Figures/Tables 1

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