Effect of soft silicone silver ion dressing applied in burn
wounds

doi:10.3969/j.issn.2095-4344.2271

Abstract

Abstract:

BACKGROUND: Soft silicone silver ion dressing, a kind of high molecular weight organic compound prepared with Safetac technology, has the characteristics of anti-infection, good permeability and good air permeability. It can provide a good moist environment for wound healing.

OBJECTIVE: To evaluate the effectiveness of soft silicone silver ion dressings in repairing deep II degree and milder burn wounds.

METHODS: A computer-based retrieval of CNKI, VIP, WanFang, CBM, PubMed, Embase and Web of Science databases was performed. The randomized controlled trials concerning soft silicone silver ion dressing for repairing deep II degree and milder burn wounds were selected. The treatment group was treated with a single soft silicone silver ion dressing, or a soft silicone silver ion dressing combined with conventional treatment, or combined with other treatments. The control group was treated with conventional treatment, or other treatments, or placebo. After screening, data extraction and quality evaluation, meta-analysis was performed using Review Manager 5.3 software.

RESULTS AND CONCLUSION: (1) Eleven articles were included, involving 784 patients, 381 patients in the treatment group and 403 patients in the control group. (2) The results of meta-analysis showed that the burn wound healing rate in the treatment group was higher than that in the control group [OR=11.56, 95%CI (9.60, 13.53), P < 0.000 01; OR=13.29, 95%CI (7.54, 19.04), P < 0.000 01; OR=4.10, 95%CI (2.28, 5.93), P < 0.000 1; OR=1.17, 95%CI (0.42, 1.93), P=0.002] at 7, 14 and 21 days, and the last measurement. The healing time of burn wounds in the treatment group was shorter than that in the control group [OR=-2.81, 95%CI (-3.49, -2.12), P < 0.000 01]. The degree of pain in burn wounds in the treatment group was lower than that in the control group [OR=-0.38, 95%CI (-0.53，-0.24), P < 0.000 01]. There was no significant difference in the positive rate of bacterial culture on wound surface [OR=1.16, 95%CI (0.47, 2.85), P=0.74], burn wound infection [OR=1.44, 95%CI (0.47, 4.41), P=0.52], dressing frequency [OR=-8.04, 95%CI (-18.82, 2.74), P=0.14], wound treatment cost [OR=-98.26, 95%CI (-272.91, 76.40), P=0.27] and adverse reaction [OR=0.61, 95%CI (0.31, 1.20), P=0.15] between treatment and control groups. (3) These results show that the application of soft silicone silver ion dressing on deep II degree and milder burn wounds can improve wound healing rate, shorten wound healing time and alleviate pain.

Key words: soft silicone silver ion dressing, silver ion, dressing, silicone, burn, burn wound, meta-analysis, wound healing

CLC Number:

Zhong Shuxian, Shi Yuqing, Yang Yalan, Li Chun. Effect of soft silicone silver ion dressing applied in burn wounds[J]. Chinese Journal of Tissue Engineering Research, 2020, 24(22): 3602-3608.

Figures/Tables 15

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