Chinese Journal of Tissue Engineering Research ›› 2022, Vol. 26 ›› Issue (25): 4093-4100.doi: 10.12307/2022.419
Shi Yao1, Han Shufeng2, Yuan Yitong3, Du Ruochen3, Jing Zhijie3, Zhao Bichun3, Zhang Ruxin3, Zhang Yujuan3, Wang Chunfang3
Received:
2021-03-29
Accepted:
2021-05-08
Online:
2022-09-08
Published:
2022-01-26
Contact:
Han Shufeng, Master, Professor, Chief physician, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
Wang Chunfang, PhD, Professor, Experimental Animal Center of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
About author:
Shi Yao, Master candidate, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
Supported by:
CLC Number:
Shi Yao, Han Shufeng, Yuan Yitong, Du Ruochen, Jing Zhijie, Zhao Bichun, Zhang Ruxin, Zhang Yujuan, Wang Chunfang. Efficacy and safety of human umbilical cord mesenchymal stem cells in the treatment of spinal cord injury: a meta-analysis[J]. Chinese Journal of Tissue Engineering Research, 2022, 26(25): 4093-4100.
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2.5 敏感性分析结果 在ASIA运动功能评分的Meta分析结果中,有9篇文献比较了人脐带间充质干细胞移植组与对照组的ASIA运动功能评分[8-16],异质性检验提示纳入的研究之间异质性较大(P < 0.000 01,I2=81%),采用随机效应模型进行Meta分析,结果显示人脐带间充质干细胞移植组的ASIA运动功能评分与对照组相比,差异无显著性意义(MD=3.48,95%CI:-0.14-7.10,P=0.06)。因此,需要对这项指标进行敏感性分析,经过逐一剔除纳入文献后,发现徐远红等[11]的研究结果对异质性的影响较大,剔除后发现,异质性明显降低(P=0.11,I2=40%),采用固定效应模型进行Meta分析,结果显示人脐带间充质干细胞移植组的ASIA运动功能评分高于对照组(MD=6.14,95%CI:4.46-7.81,P < 0.000 01),见图10。因此,对于人脐带间充质干细胞移植组的ASIA运动功能评分与对照组相比差异无显著性意义的这一结论要谨慎对待。"
在日常生活能力评分(Barthel指数量表)的Meta分析结果中,有5篇文献比较了人脐带间充质干细胞移植后与对照组的日常生活能力评分[8,12,14-16],异质性检验提示纳入的研究之间异质性较大(P=0.07,I2=54%),采用随机效应模型进行Meta分析,结果显示人脐带间充质干细胞移植组的日常生活活动能力评定高于对照组,差异有显著性意义(MD=5.12,95%CI:1.04-9.20,P=0.01)。因此,需对这项指标进行敏感性分析,经过逐一剔除纳入文献后,发现郭钢花等[16]的研究结果对异质性的影响较大,剔除此研究后发现异质性明显降低(P=0.27,I2=24%),采用固定效应模型进行Meta分析,结果显示人脐带间充质干细胞移植组的日常生活能力评分依旧高于对照组,且差异有显著性意义(MD=7.18,95%CI:3.93-10.42,P < 0.000 1),见图11。说明人脐带间充质干细胞移植组的日常生活能力评分高于对照组这一结论稳健可靠。"
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