Chinese Journal of Tissue Engineering Research ›› 2022, Vol. 26 ›› Issue (4): 643-648.doi: 10.12307/2022.105

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Platelet-rich fibrin as a material for alveolar ridge preservation significantly reduces the resorption of alveolar bone height and width after tooth extraction: a meta-analysis

Wei Zhoudan1, Li Wenjin2, Zhu Li2, Wang Yu2, Zhao Jiaoyang1, Chen Yanan1, Guo Dong1, Hao Min2   

  1. 1Stomatological Hospital, School of Stomatology, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China; 2Department of Stomatology, Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
  • Received:2020-09-08 Revised:2020-09-11 Accepted:2020-10-16 Online:2022-02-08 Published:2021-12-06
  • Contact: Li Wenjin, MD, Master’s supervisor, Associate chief physician, Department of Stomatology, Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
  • About author:Wei Zhoudan, Master candidate, Physician, Stomatological Hospital, School of Stomatology, Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
  • Supported by:
    Scientific Research Project of Shanxi Health and Health Commission, No. 2019042 (to LWJ); Shanxi Province Applied Basic Research Program, No. 201901D111385 (to LWJ); Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province, No. 20200010 (to LWJ) 

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Abstract: OBJECTIVE: At present, platelet-rich fibrin is widely used in site retention after tooth extraction, but the effect of platelet-rich fibrin in alveolar ridge preservation is not very clear compared with other materials. This study evaluated the effect of applied platelet-rich fibrin in the preservation of alveolar ridge after tooth extraction to provide theoretical basis for clinical application of platelet-rich fibrin to reduce alveolar bone resorption. 
METHODS: Up to June 2020, all clinical randomized controlled studies on platelet-rich fibrin for alveolar ridge preservation, including platelet-rich fibrin alone and platelet-rich fibrin combined with heterogeneous bone, were collected by using The Cochrane Library, PubMed, Web of science core set, EMbase, CNKI, and Wanfang databases. Two researchers extracted data from the retrieved documents and used Cochrane bias risk assessment tools to evaluate the bias risk included in the study. RevMan 5.3 software was used for meta-analysis.
RESULTS: (1) Totally 159 articles were retrieved, and 11 randomized controlled trials were finally included, involving 531 patients and 575 implants. (2) The results of meta-analysis showed that the difference in the height absorption of tooth alveolar bone was not statistically significant when platelet-rich fibrin was applied alone (SMD=-0.38, 95%CI:-0.83 to -0.06, P > 0.05). There were significant differences between platelet-rich fibrin composite heterogeneous bone and simple xenogeneic bone in alveolar bone resorption height (3 months: SMD=-1.40, 95%CI:-1.79 to -1.01, P < 0.05; 6 months: SMD=-1.37, 95%CI:-1.68 to -1.06, P < 0.05), alveolar bone resorption width at 3 and 6 months after tooth extraction (SMD=-0.18, 95%CI:-0.25 to -0.11, P < 0.05), and mouth mucosa healing rate at 2 weeks after tooth extraction (SMD=9.90, 95%CI:8.61-11.19, P < 0.05). 
CONCLUSION: Applying platelet-rich fibrin composite heterogeneous bone after tooth extraction can remarkably reduce the resorption of alveolar bone both in height and width and accelerate soft tissue healing. Because of the small sample size included in the study, clinical studies with a large sample size are needed to verify the above conclusions.

Key words: tooth, alveolar, platelet-rich fibrin, inorganic bovine bone material, site preservation, bone resorption, meta-analysis, randomized controlled trial

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