Chinese Journal of Tissue Engineering Research ›› 2020, Vol. 24 ›› Issue (10): 1604-1614.doi: 10.3969/j.issn.2095-4344.2221

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Polymer nanomedicines for osteosarcoma therapy

Li Ke1, 2, Xu Weiguo2, Huang Chao2, 3, Zhang Zhiyu1, Ding Jianxun2   

  1. 1Department of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning Province, China; 2Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin Province, China; 3Department of Hand Surgery, The Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
  • Received:2019-05-25 Revised:2019-06-13 Accepted:2019-07-20 Online:2020-04-08 Published:2020-02-18
  • Contact: Zhang Zhiyu, MD, Professor, Department of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning Province, China
  • About author:Li Ke, Master candidate, Department of Orthopedics, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning Province, China; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin Province, China
  • Supported by:
    the National Natural Science Foundation of China, No. 51873207, No. 51673190

Abstract:

BACKGROUND: In recent years, various polymer nanoparticles have been developed as anticancer drug carriers to prolong blood circulation time and improve intratumoral accumulation, and then enhance the therapeutic efficacy on osteosarcoma.

OBJECTIVE: To review the application and development of polymer nanomedicines for treatment of osteosarcoma based on latest related studies.

METHODS: A computer-based online search of Web of Science, NCBI, and PubMed was performed to search publications published between January 1900 and June 2019 with the search terms “osteosarcoma; polymer; nanoparticle; controlled drug delivery; tumor therapy". A total of 265 publications were screened out, and 107 of them regarding polymer nanoparticles for treatment of osteosarcoma were included in the final analysis.

RESULTS AND CONCLUSION: Osteosarcoma is the most common primary malignant bone tumor, mainly affecting children and adolescents. The long-term survival rate of osteosarcoma patients is low due to early lung metastasis and high local invasiveness. Although chemotherapy increases the survival rates of patients with osteosarcoma, its application potential is limited by severe side effects and drug resistance. Compared with traditional chemotherapy, polymer nanomedicines reduce the toxicity to healthy tissues, prolong the blood circulation time in vivo, and provide continuous release of chemotherapy drugs at the tumor sites, thereby improving the therapeutic efficacy. Therefore, polymer nanomedicines have great application prospects in the treatment of osteosarcoma because of their unique advantages.

Key words: osteosarcoma, polymer, nanoparticle, controlled drug delivery, tumor therapy, polymer nanomedicine, bone tumor, tissue engineering

CLC Number: