Analgesic effect of periarticular multimodal drug injection versus nerve block in total knee arthroplasty

doi:10.3969/j.issn.2095-4344.2017.23.007

Abstract

Abstract:

BACKGROUND: Periarticular multimodal drug cocktail injection for pain management after total knee arthroplasty (TKA) has been reported, but there are few studies concerning its effect on the range of motion and volume of drainage postoperative, and difference to nerve block.

OBJECTIVE: To compare the analgesic effect of periarticular multimodal drug injection and nerve block in TKA.

METHODS: Fifty-eight patients undergoing primary unilateral TKA in the First Affiliated Hospital of Anhui Medical University from 1 June 2016 to 31 October 2016 were randomly assigned to experimental and control groups (n=29 per group), followed by received a periarticular intraoperative injection of a 100 mL mixture containing ropivacaine, epinephrine, morphine, and normal saline, and preoperative combined femoral and sciatic nerve block, respectively. Subsequently, the Visual Analogue Scale scores, and range of motion, volume of drainage, hospitalization time, number of the patients given remedial analgesia and complications were compared between two groups.

RESULTS AND CONCLUSION: (1) The Visual Analogue Scale scores at rest in the experimental group were significantly lower than those in the control group at 3 days after surgery (P < 0.05). (2) The Visual Analogue Scale scores on movement in the experimental group were significantly lower than those in the control group at 1, 2 and 3 days after surgery (P < 0.05). (3) There were no significant differences in the range of motion, volume of drainage, hospitalization time and number of the patients give remedial analgesia between two groups postoperatively (P > 0.05). (4) None appeared with obvious nausea, vomiting and other complications in the two groups. (5) These results indicate that the analgesic effect of periarticular multimodal drug injection is superior to nerve block, and the former is easy to operate, economical and practical.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: Arthroplasty, Replacement, Knee, Prosthesis Implantation, Analgesia, Tissue Engineering

CLC Number:

R318

Zhu Xian-yang, Yin Zong-sheng, Lu Ming, Jiang Zheng. Analgesic effect of periarticular multimodal drug injection versus nerve block in total knee arthroplasty [J]. Chinese Journal of Tissue Engineering Research, 2017, 21(23): 3646-3651.

Figures/Tables 3

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