Drainage at different time points after tranexamic acid administration in total hip arthroplasty: a retrospective study

doi:10.3969/j.issn.2095-4344.2017.23.004

Abstract

Abstract:

BACKGROUND: Topical tranexamic acid (TXA) administration has been described to be effective in decreasing blood loss in total hip arthroplasty (THA). Most of research focus on the postoperative total drainage, but the drainage at different time points after replacement is little reported.

OBJECTIVE: To investigate the effect of topical TXA on the volume of drainage at different time points after THA.

METHODS: Data of 79 cases of primary unilateral THA were analyzed retrospectively, and allotted to two groups. TXA group (n=38) was subjected to the reverse perfusion of 1.5 g of TXA (50 mL) by drainage tube after THA, and control group (n=41) was given 50 mL of normal saline in the same way. The postoperative drainage at 1, 2 and 3 days, total postoperative drainage, and hemoglobin level at postoperative 3 days were collected and compared between two groups.

RESULTS AND CONCLUSION: There was no significant difference in the baseline data between two groups (P > 0.05). (1) The postoperative drainage at 1 day and total drainage in the TXA group was significantly lower than that in the control group, and the drainage showed no significant difference at postoperative 2 and 3 days between two groups (P > 0.05). (2) The hemoglobin level was significantly increased in the TXA group compared with the control group at 3 days postoperatively (P < 0.05). (3) To conclude, the topical TXA administration can reduce the postoperative drainage in primary unilateral THA, especially at the first day.

中国组织工程研究杂志出版内容重点：人工关节；骨植入物；脊柱；骨折；内固定；数字化骨科；组织工程

Key words: Arthroplasty, Replacement, Hip, Drainage, Tissue Engineering

CLC Number:

R318

Hao Shen-shen, Liu Yan-xiong, Liu Zhi-bin. Drainage at different time points after tranexamic acid administration in total hip arthroplasty: a retrospective study[J]. Chinese Journal of Tissue Engineering Research, doi: 10.3969/j.issn.2095-4344.2017.23.004.

Figures/Tables 2

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