Implant fixation with titanium alloy repairs spinal tuberculosis: its biocompatibility and mechanical properties

doi:10.3969/j.issn.2095-4344.2016.30.015

Abstract

Abstract:

BACKGROUND: Currently, surgical implant fixation is mainly applied for spinal tuberculosis. How to choose implant materials, however, is still under discussion.
OBJECTIVE: To compare the biocompatibility and mechanical properties of titanium alloy and stainless steel for rabbit spinal tuberculosis.
METHODS: Thirty rabbits were chosen to prepare spinal tuberculosis models. Then, the rabbits were equivalently randomized into two groups, which underwent implant fixation with stainless steel or titanium alloy, respectively. At 30 days after implantation, biocompatibility and biomechanical properties of the two materials in the repaired region of spine were observed and detected, respectively.
RESULTS AND CONCLUSION: In view of the biocompatibility, infection and immunological rejection could not been found in the titanium alloy group; in contrast, infection appeared in three rabbits of the stainless steel group. Flexion, extension and lateral bending displacements under the spinal loading in the titanium alloy group were significantly less than those in the stainless steel group (P < 0.05); axial pull-out strength in the titanium alloy group was significantly higher than that in the stainless steel group (P < 0.05); flexion, extension, lateral bending and axial compression in the titanium alloy group were significantly greater than those in the stainless steel group (P < 0.05). In conclusion, titanium alloy material has good biocompatibility that can be used to restore and maintain the spinal stability.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: uberculosis, Spinal, Stainless Steel, Biomechanics, Tissue Engineering

CLC Number:

R318

Zhuang Yong, Shang Xian-wen, Zhang Hao, Liu Miao, Xu Shun-en. Implant fixation with titanium alloy repairs spinal tuberculosis: its biocompatibility and mechanical properties[J]. Chinese Journal of Tissue Engineering Research, 2016, 20(30): 4509-4514.

Figures/Tables 4

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