Application of medical fibrin glue and stitch in pterygium excision: a Meta-analysis

doi:10.3969/j.issn.2095-4344.2015.47.029

Abstract

Abstract:

BACKGROUND: Currently, in pterygium excision combined with limbal epithelial transplantation, there were still some controversies about whether the medical fibrin glue could instead of stitch fixing autologous conjunctival graft.

OBJECTIVE: To compare the therapeutic effect of medical fibrin glue and stitch in pterygium excision combined with limbal epithelial transplantation using Meta analysis.

METHODS: The randomized controlled trials about the therapeutic effect of medical fibrin glue versus stitch in pterygium excision combined with limbal epithelial transplantation were reviewed from PubMed database, CNKI full-text database, Chinese Biomedical Literature Database, VIP database and Wanfang database from database creation to June 2015. The operative time, complications and recurrence rate of these two groups were analyzed using Meta.

RESULTS AND CONCLUSION: A total of 14 randomized controlled trials, and 879 patients were enrolled. Meta-analysis results showed that the operative time, incidence of postoperative complications, the relapse rate after six months and one-year in the fibrin glue group were lower than those in the suture group [MD=-15.58, 95%CI (-18.96, -12.21), P < 0.000 01]; [OR=0.39, 95%CI (0.19, 0.68), P=0.02]; [OR=0.28, 95%CI (0.12, 0.65), P=0.003]; [OR=0.23, 95%CI (0.07, 0.76), P=0.02]. These results demonstrate that the application of fibrin glue in pterygium excision combined with limbal stem cell transplantation can promote graft attachment, shorten the operation time, reduce postoperative complications and reduce the postoperative recurrence of pterygium.
中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

Key words: Fibrin Tissue Adhesive, Sutures, Meta-Analysis, Pterygium, Tissue Engineering

Guo Zi-jun, Wang Wei . Application of medical fibrin glue and stitch in pterygium excision: a Meta-analysis[J]. Chinese Journal of Tissue Engineering Research, 2015, 19(47): 7703-7708.

Figures/Tables 5

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